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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 7902357 | Process for the preparation of delmopinol and derivatives thereof A process for the preparation of delmopinol (3-(4-propylheptyl)-4-morpholinethanol) or a derivative or a pharmaceutically acceptable salt, or a solvate thereof, including an hydrate, comprises reacting oxazolidin [2, 3-c] morpholine and a grignard reagent, and optio... | 03/08/2011 |
| 7893258 | Preparation of delmopinol It comprises a preparation process of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by submitting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consist... | 02/22/2011 |
| 7847096 | 4-aminophenylmorpholinone derivatives and their preparation The invention relates to novel aminophenylmorpholinone derivates (I) in which S represents an optionally substituted morpholinone radical, to a process for their preparation and to their use. ... | 12/07/2010 |
| 7521552 | Process for preparation of substituted amino alcohols There is provided a process for the preparation of substituted amino alcohols HO—(CH2)n—NR1R2 from haloalcohols HO—(CH2)n—X, where X is Cl, Br or I, by reaction with an amine HNR1R | 04/21/2009 |
| 7378521 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor. ... | 05/27/2008 |
| 7361757 | Method for synthesizing esters of N-[(S)-1-carboxybutyl]-(S)-alanine and use thereof for synthesizing perindopril A process for the synthesis of compounds of formula (I): wherein R represents a linear or branched (C1-C6)alkyl group. Application in the synthesis of perindopril and its pharmaceutically accep... | 04/22/2008 |
| 7354920 | Aryl and heteroaryl morpholine derivatives Compounds of formula (I) wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C... | 04/08/2008 |
| 7323563 | Hydroxamic acid derivatives as antibacterials A method for the treatment of bacterial infections in humans and non-human mammals, which comprises inhibiting bacterial growth by administering to a subject an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily accepta... | 01/29/2008 |
| 7323466 | Morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1 | 01/29/2008 |
| 7279478 | Cathepsin cysteine protease inhibitors This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as o... | 10/09/2007 |
| 7229803 | Reaction of (di)amines in the presence of a lysine oxidase and of a reducing agent The invention relates to methods for reacting (di)amines as substrates in the presence of a lysine oxidase arid a reducing agent, resulting in alcohols, diols or cyclic secondary amines. In a particular embodiment, the invention is directed to methods of preparing c... | 06/12/2007 |
| 7223860 | Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor. ... | 05/29/2007 |
| 7101882 | Morpholin-acetamide derivatives for the treatment of inflammatory diseases The present invention relates to novel morpholin-acetamide compounds of formula (I) useful for the treatment of inflammatory diseases. Compounds of formula (I) wherein R1, R2, R3, R | 09/05/2006 |
| 7071359 | Neuropathy improvers containing nitrogenous compounds as the active ingredient A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below | 07/04/2006 |
| 7038044 | Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates The invention relates to a process for the preparation of substituted 2-(2-arylmorpholin-2-yl)ethanol derivatives. ... | 05/02/2006 |
| 7030111 | Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA damaging treatments The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to... | 04/18/2006 |
| 6998400 | Pharmaceutically active morpholinol Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and processes for their preparation; also disclosed is a method of treatin... | 02/14/2006 |
| 6855820 | Pharmaceutically active morpholinol Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, methods for preparing them, pharmaceutical compositions comprising them, and processes for their preparation; also disc... | 02/15/2005 |
| 6790978 | Thyromimetic organic compounds Compounds of the present invention of the formula are thyromimetic agents which can be used to prevent and/or treat diseases associated with an imbalance of thyroid hormones, such as hypo- and hyper-thyroidism, obesity, ... | 09/14/2004 |
| 6749988 | Amine compounds, resist compositions and patterning process Novel amine compounds having a nitrogen-containing cyclic structure and a hydrating group such as a hydroxy, ether, ester, carbonyl, carbonate group or lactone ring are useful for use in resist compositions for preventing a resist film from thinning and also for enh... | 06/15/2004 |
| 6673794 | Substituted aminomethyl-phenyl-cyclohexane derivatives A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, ##STR1## and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are method for preparing the substituted aminomethyl-pheny... | 01/06/2004 |
| 6649616 | Substituted phenylcyclohexanecarboxamides and their use The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) ##STR1## to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.... | 11/18/2003 |
| 6617454 | Process for the preparation of amine oxides The present invention provides a process for the preparation of amine oxide by reacting a tertiary or a secondary amine with hydrogen peroxide as an oxidant in the presence of a recyclable heterogeneous catalyst comprising a layered double hydroxide excha... | 09/09/2003 |
| 6600040 | Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxa zine. This compound is useful as an intermediate in the synthesis of compounds wh... | 07/29/2003 |
| 6596772 | Phosphate mimics and methods of treatment using phosphatase inhibitors The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are rela... | 07/22/2003 |
| 6545152 | R-isomers of nonnucleoside inhibitors Novel chiral derivitaves of non-nucleoside inhibitors (NNI), particularly R-isomers of halopyridyl and thiazoyl thiourea compounds are provided as potent inhibitors of reverse transcriptase (RT), and particularly of retroviral RT, most particularly HIV RT... | 04/08/2003 |
| 6538134 | 4-Benzyl-2-hydroxy-1,4-oxazine-3-one and polymorphic forms thereof The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.... | 03/25/2003 |
| 6482860 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of dis... | 11/19/2002 |
| 6479491 | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R | 11/12/2002 |
| 6476023 | Aromatic heterocyclic compounds as anti-inflammatory agents Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions. Also disclo... | 11/05/2002 |
| 6475347 | High boiling inhibitors for distillable, polymerizable monomers Disclosed herein are compounds of the structure ##STR1## wherein R1, R2, and R3 are organic radicals of C1 to C20, such that the combination of the three contain at least twelve carbon atoms and R | 11/05/2002 |
| 6403793 | Intramolecular glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5- bis (trifluoromethyl) phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine The present invention is concerned with novel processes for the preparation of (2R-cis)-2-[[1-[3. 5-bis(trifluoromethyl)phenyl]ethenyl]oxy]-3-(4-fluorophenyl)-4-(phenylmeth yl) mopholine. This compound is useful as an intermediate in the synthesis ... | 06/11/2002 |
| 6335333 | N-arylsulfonylamino acid omega-amides Compounds of the formula I: ##STR1## stereoisomeric forms, and physiologically tolerable salts thereof are suitable for the production of pharmaceuticals for the therapy and prophylaxis of disorders involving matrix-degrading metalloproteinases.... | 01/01/2002 |
| 6294112 | Red coloring hyperchromic 3H-naphtho[2,1-B]pyrans Red coloring hyperchromic compounds have the formula: ##STR1## where R1 is H, NR2 R3, OR4, SR4 or R7 wherein R2 and R3 are alkyl or carbocyclic groups or together with the ... | 09/25/2001 |
| 6271382 | Process for producing organic compound having nitroxide free radical An organic compound having a nitroxide free radial of the formula (2) is prepared by reacting a cyclic secondary amine having a steric hindrance of the formula (1) with a peroxide in the presence of at least 1 part by weight of an organic compound having ... | 08/07/2001 |
| 6255550 | Stabilization of the reagent dimethyl titanocene The present invention is directed to organic solutions of the reagent dimethyl titanocene which further comprise a sterically hindered ester and optionally titanocene dichloride. Stability of the reagent dimethyl titanocene is enhanced by the presence of ... | 07/03/2001 |
| 6200972 | Heterocyclic esters and amides This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particular... | 03/13/2001 |
| 6187918 | Catalysts for asymmetric addition of organozinc reagents to aldehydes and method for preparation Novel chiral aminoalcohol catalysts and methods for their preparation are provided. The first catalyst is prepared via selective hydrogenation of one of two benzene rings in a precursor. The aminoalcohol promotes the asymmetric addition of organozinc reag... | 02/13/2001 |
| 6177564 | Process for the synthesis of N-benzyl-3-(4-fluorophenyl)-1-4-oxazin-2-one The present invention is concerned with a novel process for the preparation of N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one of the formula: ##STR1## This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological act... | 01/23/2001 |
| 6162425 | Saturated, alkyl-substituted n-mercaptoacetyl heterocyclic compounds and compositions and methods for permanent shaping of hair based on same and processes for making same The composition for permanent shaping of hair contains, as keratin-reducing agent, a compound of the formula (I): ##STR1## or a salt thereof, wherein R1, R2, R3 and R4 each represent, independently of each ... | 12/19/2000 |
