Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7365070 | Modulators of melanocortin receptor This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by formula I: ... | 04/29/2008 |
| 7250415 | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof of Formula I: P-M-M1I or a stereo... | 07/31/2007 |
| 7160874 | Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin. ... | 01/09/2007 |
| 7144881 | Arylcyclopropylcarboxylic amides as potassium channel openers The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I wherein R, R1, R2, R3, R4, R5, R | 12/05/2006 |
| 7045551 | 1-aryl-2-hydroxyethyl amides as potassium channel openers The present invention provides novel aryl hydroxyethyl amides and related derivatives having the general Formula I wherein R1, R2, R3, R4, R5, R6,... | 05/16/2006 |
| 7001905 | Substituted diarylamines as MEK inhibitors Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are us... | 02/21/2006 |
| 6992081 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases. ... | 01/31/2006 |
| 6903092 | Naphthamide neurokinin antagonists for use as medicaments Compounds having the general formula wherein R1, R2, R3, R4, R5, X1 and X2 are as defined in the specification, methods of using such compoun... | 06/07/2005 |
| 6855706 | Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin. ... | 02/15/2005 |
| 6806365 | N-alkanoylphenylalamine derivatives Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related t... | 10/19/2004 |
| 6689882 | Process for the synthesis of morpholinylbenzenes A new improved process for synthesizing morpholinylbenzenes of the formula I by reacting morpholine of formula II with a substituted benzene of formula III, wherein morpholine is used as a reactant and as the only one solvent. ##STR1##... | 02/10/2004 |
| 6649587 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as c... | 11/18/2003 |
| 6534545 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: ##STR1## X represents: (i) either a radical of formula: (a) ##STR2## and Y represents a radical of formula: (b) ##STR3## (ii) or a radical of formula: (c... | 03/18/2003 |
| 6492362 | Compounds and compositions as cathepsin S inhibitors The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.... | 12/10/2002 |
| 6479491 | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R | 11/12/2002 |
| 6407064 | Aminoalcohol derivative and medicament comprising the same An aminoalcohol derivative which is a ceramide analogue, and a medicament, especially an agent for treating neuronal diseases and an agent for protecting brain, comprising the same.... | 06/18/2002 |
| 6197817 | Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders Disclosed are compounds of the formula: ##STR1## R represents hydrogen or is a C-3 to C-6 cycloalkyl or C-4 to C-10 straight or branched carbon chain alkyl-cycloalkyl or a group --B--D, where B is C-2 to C-10 straight or branched carbon chain alkyl and D ... | 03/06/2001 |
| 6174885 | [6-(substituted-methyl)-3-cyclohexenyl] formamide derivative, hair growth promoter and external composition for skin A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is--(CH2 | 01/16/2001 |
| 6159973 | Aromatic amides, their preparation process, the compositions containing them and their use as pesticides The subject of the invention is the compounds of formula (I): Q(CH2)a --(X1)b --Q1 --Q2 --C(X2)--N(R1)(R2) (I) in which: Q represents an aryl ... | 12/12/2000 |
| 6147196 | Process for producing esters of fatty substances and the high purity esters produced In order to produce a composition of esters of linear monocarboxylic acids containing 6 to 26 carbon atoms and glycerine simultaneously with high degrees of purity, the following is carried out: a step a) in which a plant or animal oil, which may or may not be... | 11/14/2000 |
| 6124333 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124332 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124329 | Metalloproteinase inhibitors Compounds of general formula (II) ##STR1## wherein R1, R2 and Z are defined in the claims, are matrix metalloproteinase inhibitors.... | 09/26/2000 |
| 6114325 | 1,2-di-substituted benzene-carboxamide derivative, hair growth promoter and external composition for skin using the same A 1,2-di-substituted benzene-carboxamide derivative or a salt thereof expressed by the following Formula (I); ##STR1## wherein each of A and B is R1 or --(CH2)n-NR2 R3, wherein when A is R1, B is... | 09/05/2000 |
| 6017917 | Guanidine derivatives Guanidine derivatives of the formula: ##STR1## wherein R1 is [di(lower)alkylamino](lower)alkyl, morpholinyl(lower)alkyl, lower alkylpiperazinyl or [lower alkylpyrrolidinyl](lower)alkyl, R2 is halogen, lower alkyl or lower alkoxy... | 01/25/2000 |
| 5972939 | Cyclopentene derivatives useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonis... | 10/26/1999 |
| 5814634 | Alkylenediamine derivative anti-ulcer drug and antibacterial drug The invention provides a compound which has anti-ulcer effect and antibacterial activity against Helicobacter pyroli. This compound is an alkylenediamine derivative or salt which has a general formula of (1): ##STR1## wherein each of R4, R... | 09/29/1998 |
| 5804581 | Inhibition of matrix metalloproteases by substituted phenalkyl compounds Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the generalized formula: ##STR1## wherein T is a substituent an... | 09/08/1998 |
| 5753652 | Antiretroviral hydrazine derivatives The invention relates to compounds of formula ##STR1## and salts, pharmaceutical compositions, intermediates and processes of preparation thereof.... | 05/19/1998 |
| 5731435 | Process for the preparation of heterocyclic alkylamide derivatives The present invention relates to a novel process for the preparation of N-heterocyclealkanamide derivatives having the following formula: ##STR1## which comprises reacting 1-(2-chloroethyl)piperidine with 2-chlorobenzeneacetonitrile to give (&#b... | 03/24/1998 |
| 5705640 | O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same The present invention relates to O-carbamoyl-(D)-phenylalaninol compound represented by the following structural formula V and pharmaceutically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein R1 a... | 01/06/1998 |
| 5686588 | Amine acid salt compounds and process for the production thereof A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform size and shape.... | 11/11/1997 |
| 5591846 | Nonionic radiographic contrast agents New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, ##STR2## R1, R1 ' and R2 are the same or different and are hydrogen, alkyl or hydroxyalkyl. Hydroxyalkyl refers to... | 01/07/1997 |
| 5563168 | O-Benzyloxime ethers and crop protection agents containing these compounds O-Benzyloxime ethers of the formula I ##STR1## where 5 X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cy... | 10/08/1996 |
| 5559153 | Urea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them Urea-substituted benzoylguanidines, process for their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them There are described benzoylguanidines of the formula I ##STR1## where R(1), R(3) or R(4) is --NR(6) C.dbd.X NR... | 09/24/1996 |
| 5500422 | Benzamide derivative A benzamide derivative represented by the following formula: ##STR1## wherein R1 represents a hydrogen atom or a lower alkanoyl group; R2 represents a hydrogen atom or a halogen atom; R3 represents a lower alkoxy grou... | 03/19/1996 |
| 5457122 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, possess an antagonistic activity on leukotriene B4.... | 10/10/1995 |
| 5453517 | Reactive derivatives of bapta used to make ion-selective chelators The invention relates to fluorescent and/or reactive derivatives of 1,2-bis-(2-aminophenoxyethane)-N,N,N',N'-tetraacetic acid (BAPTA) according to the formula: ##STR1## where at least one of W and X is a functional group, with or without a space... | 09/26/1995 |
| 5409927 | Morpholin- and thiomorpholin-4-ylamides There are described compounds of formula I ##STR1## wherein R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxycarbonyl, phenyl- or naphthyl-lower alkoxycarbonyl, heterocyclylcarbonyl wherein heterocyclyl co... | 04/25/1995 |
| 5401775 | Tri(lower alkoxy)benzene derivatives This invention relates to a tri(lower alkoxy)benzene derivative of the general formula (I), or its salt, optical isomer or solvate, ##STR1## wherein: R1, R2 and R3 : same or different and each represents a lower alkyl... | 03/28/1995 |
