Class 544/149 - The additional hetero ring is six-membered

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the additional hetero ring is six-membered.
No. of patents: 84
Last issue date: 11/04/2008

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Number	Title	Issue Date
7446196	Leptomycin compounds Leptomycin-type compounds according to Formula I wherein R0, R1, R2, R10, R11, R12, R13, R14, and m are as defined herein, exhibit anti...	11/04/2008
7423037	Morpholine derivatives as norepinephrine reuptake inhibitors Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system. ...	09/09/2008
7312211	Pryanone compounds useful as reversible inhibitors of cysteine proteases Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R2, R3, R4, R6, R8 and Y are defined herein. The compounds are useful for treating autoimmune and othe...	12/25/2007
7189714	N-type calcium channel antagonists for the treatment of pain Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2 and R3 are any of a number of groups as defined in the specification and...	03/13/2007
7053212	Acyclic amide and sulfonamide ligands for the estrogen receptor The present invention provides estrogen receptor (ER) ligands of structural formula (I) the pharmaceutically acceptable salts, stereoisomers, and prodrugs thereof, and the pharmaceutically acceptable salts of the...	05/30/2006
7026352	Physiologically active substances The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incuba...	04/11/2006
6927217	HIV protease inhibitors The present invention relates to novel dihydropyrones of Formula I wherein X is NH or NR8, which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development o...	08/09/2005
6833367	Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating ...	12/21/2004
6756372	Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds. ...	06/29/2004
6743788	Carbamate and oxamide compounds Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are ...	06/01/2004
6586428	Combined preparations comprising morpholine anthracyclines and anticancer agent The present invention relates to combined preparations comprising a morpholinyl anthracycline administered in combination anticancer agents chosen from an alkylating agent, an antimetabolite, a topoisomerase II inihbitor, a topoisomerase I inhibitor, an a...	07/01/2003
6537990	Combined preparations comprising morpholine anthracyclines and anticancer agent The present invention relates to combined preparations comprising a morpholinyl anthracycline administered in combination anticancer agents chosen from an alkylating agent, an antimetabolite, a topoisomerase II inhibitor, a topoisomerase I inhibitor, an a...	03/25/2003
6458830	Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates to compounds of the formula (I): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are defined herein. The ...	10/01/2002
6316505	Pharmaceutical compositions comprising fluorinated co-polymers Block copolymers containing a fluorinated hydrocarbon unit, a hydrocarbon unit, and a poly(oxyethylene) unit are useful in fluid formulations of pharmaceutical agents. A typical embodiment is: C11 H23 --CONHC2 H4 NHC...	11/13/2001
6265446	Hydrazine derivatives Hydrazine derivatives of the formula ##STR1## wherein R1 represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl, R2 represents heterocyclyl or NR5 R6, R	07/24/2001
6117870	Cyclic amide derivatives A cyclic amide derivative of formula (I): ##STR1## wherein R1 represents a substituted alkyl group, a substituted alkenyl group, a substituted amino group, a substituted alkoxyl group, a substituted alkylthio group, a substituted carbamoyl...	09/12/2000
6113812	Photochromic articles A photochromic article that includes a host material and a photochromic amount of a benzopyran compound, the benzopyran compound represented by one of the formulas: ##STR1## wherein R1, R2, R3, R4, R5	09/05/2000
6087359	Thioaryl sulfonamide hydroxamic acid compounds A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhi...	07/11/2000
6005103	Pyrone derivatives as protease inhibitors and antiviral agents The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment ...	12/21/1999
5969140	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor Naphthalene derivatives of the formula [I]: ##STR1## wherein R1 and R2 are the same or different and are each H, protected or unprotected OH, one of R3 and R4 is protected or unprotected hydroxymethyl, and ...	10/19/1999
5914351	Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a...	06/22/1999
5869662	Photochromic benzopyran compounds Benzopyran compounds represented by the formulas: ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are selected from hydrogen, a stab...	02/09/1999
5808062	Pyrone derivatives as protease inhibitors and antiviral agents The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment ...	09/15/1998
5795981	Processes for the preparation of squarylium dyes Squarylium compounds of the formula: ##STR1## (in which Q1 and Q2 are each a chromophoric group having an aromatic unsaturated system conjugated with the squarylium ring and such that in the compounds of formulae Q1 C...	08/18/1998
5789440	5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the tre...	08/04/1998
5744070	Photochromic substituted naphthopyran compounds Described are novel reversible photochromic naphthopyran compounds, examples of which are 3H-naphtho2,1-b!pyrans having an acyl or aroyl oxy-bearing substituent at the number 6 carbon atom and certain substituents at the 3-position of the pyran ring. Ce...	04/28/1998
5714484	଱-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a ...	02/03/1998
5658942	Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkadienyle...	08/19/1997
5656750	Processes for the preparation of squarylium dyes Squarylium compounds of the formula: ##STR1## (in which Q1 and Q2 are each a chromophoric group having an aromatic unsaturated system conjugated with the squarylium ring and such that in the compounds of formulae Q1 C...	08/12/1997
5656656	Tartronic acids, their acetalic ethers and O-esters Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C2 -C12 acyl group, R is phenyl and n is 0...	08/12/1997
5654122	N-aminopyridone dyes Pyridone dyes useful for thermal transfer have the formula ##STR1## where R1 is hydrogen or C1 -C4 - alkyl, R2 and R3 are identical or different and each is, independently of the other, hydrogen, subs...	08/05/1997
5599820	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## ...	02/04/1997
5580980	N-aminopyridone dyes Pyridone dyes useful for thermal transfer have the formula ##STR1## wherein R1, R2, R3, Y, X and Z are defined in the specification....	12/03/1996
5498634	Thioformamide derivatives The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: ...	03/12/1996
5496943	Heterocyclic compounds and their production Disclosed is a novel heterocyclic compound selected from the group consisting of the compounds [IV] to [VII], [IX] and [X]. The heterocyclic compound is useful for reactive materials in chemical industry. A process for producing the heterocyclic compound ...	03/05/1996
5476935	Dyes for use in thermal dye transfer Dye-donor element for use according to thermal dye transfer comprising least one dye corresponding to the general formula (I): ##STR1## wherein Z is --CN, --COOR1 or --CONR2 R3 ; R1 is --H, (cyclo)alkyl, or...	12/19/1995
5459131	Renin inhibitors Renin inhibiting compounds of the formula: ##STR1## wherein A is a moiety selected from those of the formula: ##STR2## where Z is O, S, SO, or SO2, P is 1 or 2 and X is --O-- or --S--; and analogs thereof which inhibit the substrate-c...	10/17/1995
5446062	((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase Compounds of the structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R6 and R7 are hydrogen or alkyl, or R6 and R7, together with the nitrogen atoms to which they are ...	08/29/1995
5393729	3-aryl-pyrone derivatives The invention relates to 3-aryl-pyrone derivatives of the general formula (I) ##STR1## in which the substituents are as defined in the specification. The compounds are useful as pesticides, herbicides and fungicides....	02/28/1995
5354873	Squarylium dyes, and processes and intermediates for the preparation thereof Squarylium compounds of the formula: ##STR1## (in which Q1 and Q2 are each a chromophoric group having an aromatic unsaturated system conjugated with the squarylium ring and such that in the compounds of formulae Q1 C...	10/11/1994

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Class 544/149 - The additional hetero ring is six-membered