Class 544/145 - Sulfur containing hetero ring (e.g., thioxane, etc.)

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds having, in addition to the morpholine ring, a
No. of patents: 181
Last issue date: 09/30/2008

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Number	Title	Issue Date
7429660	ATM inhibitors A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an op...	09/30/2008
7429667	Phenylamino isothiazole carboxamidines as MEK inhibitors The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones. ...	09/30/2008
7405212	Helix mimetics and composition and methods related thereto Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y,...	07/29/2008
7208491	N-monoacylated o-phenylenediamines Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as c...	04/24/2007
7202242	Substituted 1 and 2-naphthol Mannich bases The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments. ...	04/10/2007
7105518	Thiopyrane-4-ones as DNA protein kinase inhibitors The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R1 and R2 are independently hydrogen, an option ally substituted C1-7 alkyl group, C...	09/12/2006
7067516	Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ...	06/27/2006
7049313	ATM inhibitors The application concerns a compound of formula I: wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3	05/23/2006
6972292	Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ...	12/06/2005
6849658	Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is CH3, —CH2—O—R6, —OR6 or —COR7; R2 is —OR8, —SR8	02/01/2005
6849733	Neuropeptide-Y ligands There are disclosed novel neuropeptide Y ligands having the general formula I Wherein the symbols W, A, D, R1, R2, R3, R4 are further defined in the description. Compounds of...	02/01/2005
6756372	Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds. ...	06/29/2004
6730670	7-phenyl-benzo[b]thiophen amide derivatives A compound of the formula Compounds of formula I have a good affinity to the A2A receptor and are useful for the treatment of diseases mediated by this receptor. ...	05/04/2004
6730671	Compounds useful as reversible inhibitors of cathespin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes, for making such novel compounds.	05/04/2004
6686467	Amide derivatives for the treatment of diseases mediated by cytokines The invention concerns the use of amide derivatives of formula (I) wherein: R1 and R2 are substituents such as hydroxy, C1-6 alkoxy, mercapto, C1-6 alkylthio, amino, C1-6 alkylamino and di-(C1-6	02/03/2004
6638930	Morpholine and thiomorpholine tachykinin receptor antagonists Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiov...	10/28/2003
6608057	Compounds useful as reversible inhibitors of cathepsin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds ##STR1##...	08/19/2003
6605637	Lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping reactive oxygen speci...	08/12/2003
6544990	Substituted quinolinecarboxamides as antiviral agents The present invention discloses disubstiuted 4-oxo-1,4-dihydro-3-quinolinecarboxamide derivatives. The compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family....	04/08/2003
6525086	Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci...	02/25/2003
6498274	Amide derivatives for the treatment of diseases mediated by cytokines The invention concerns the use of amide derivatives of formula (I) wherein: R1 and R2 are substituents such as hydroxy, C1-6 alkoxy, mercapto, C1-6 alkylthio, amino, C1-6 alkylamino and di-(C1-6	12/24/2002
6440899	Cyclohexenonedioxothiochromanoyl derivatives Cyclohexenonedioxothiochromanoyl derivatives of the formula I ##STR1## where X is oxygen, sulfur, S.dbd.O, S(.dbd.O)2, CR4 R5, C.dbd.O or C.dbd.NR6, the other substituents are as defined in the specification, an...	08/27/2002
6440958	Acrylic and propionic acid compounds, intermediates, processes, compositions, and methods This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation ...	08/27/2002
6392040	Cyclopentene compounds useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the ...	05/21/2002
6391901	Thrombin inhibitors This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the ...	05/21/2002
6358885	Substituted phenylheterocyclic herbicides This invention relates to certain phenylheterocyclic compounds, herbicidal compositions thereof and a method for their use as general and selective preemergent or postemergent herbicides or plant growth regulants....	03/19/2002
6352987	8,8A-DIHYDROINDENO[1,2-D]THIAZOLE DERIVATIVES WHICH CARRY IN THE 2-POSITION A SUBSTITUENT HAVING A SULFONAMIDE STRUCTURE OR SULFONE STRUCTURE; PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 8,8a-Dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments The invention relates to polycyclic dihydrothiazoles and...	03/05/2002
6342512	Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals Sulfonylcarboxamide derivatives of formula I, their physiologically acceptable salts and/or physiologically functional derivatives, methods of making these compounds, their use for preparing medicines for the prevention and treatment of hyperlipidemia and...	01/29/2002
6313164	Dithiolin derivatives, their preparation and their therapeutic effect Compounds of the formula (I): ##STR1## wherein one of m and n is 0, and the other is 0, 1 or 2; k is 0 or 1 to 12; R1 is hydrogen, a substituent which is an aryl or a heterocyclic, or an optionally substituted alkyl group; A is a single bond, a...	11/06/2001
6284756	Antithrombotic agents This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the ...	09/04/2001
6166006	Anilide derivative, production and use thereof This invention is to provide a compound of the formula: ##STR1## wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-mem...	12/26/2000
6150358	1,2-dithiolane compounds A compound of formula (I): ##STR1## wherein Ra represents linear or branched (C1 -C8)alkylene, Rb represents single bond, or linear or branched (C1 -C6)alkylene, Z represents thiocarbamate, or thioamide, each be...	11/21/2000
6133288	Pentacyclic compounds, intermediates, processes, compositions, and methods The present invention provides compounds of formula I and II: ##STR1## wherein X is --O--, --S--, or --NR5 --; Y is --O--, --S--, --CH2 --, --CH2 CH2 --, --CH.dbd.CH--, or --NR5 --; B is --CH2	10/17/2000
6133262	Antithrombotic agents This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the ...	10/17/2000
6087359	Thioaryl sulfonamide hydroxamic acid compounds A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhi...	07/11/2000
6060468	N-substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R1a, R2, R2a, p, r and s are as defined in the detailed part of the presen...	05/09/2000
6025495	Regioselective alkylation process for preparing substituted benzo[b]thiophenes The present invention provides processes for the regioselective alkylation of benzothiophenes....	02/15/2000
6013663	Dithiolan derivatives, their preparation and their therapeutic effect A compound of formula (I): ##STR1## wherein one of m and n represents 0, and the other represents 0, 1 or 2; k represents 0 or 1 to 12; R1 is hydrogen, an aryl, a heterocyclic, an alkyl, a hydroxy or --OR7, wherein R7...	01/11/2000
5977098	Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods The invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical formulations containing a compound of formula I, and methods of using a compound of formula I for the inhibition of bone...	11/02/1999
5922706	Morpholine and thiomorpholine tachykinin receptor antagonists Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of ca...	07/13/1999

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Class 544/145 - Sulfur containing hetero ring (e.g., thioxane, etc.)