Class 544/138 - Oxadiazole ring (including hydrogenated)

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the five-membered hetero ring consists
No. of patents: 81
Last issue date: 01/27/2009

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Number	Title	Issue Date
7482448	Compounds and compositions as cathepsin inhibitors Novel inhibitors of cathepsin S, K, B, and L, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ...	01/27/2009
7390804	N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity aga...	06/24/2008
7348427	Antipathogenic benzamide compounds Antipathogenic benzamide compounds having the formula wherein at least one of the R1 groups is F, Cl, CN or CF3 and R2, R3, Y, Z, m, and n are as defined herein. ...	03/25/2008
7226921	Compounds and compositions as cathepsin S inhibitors The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ...	06/05/2007
7220745	Heterocyclic compounds useful to treat HCV The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication a...	05/22/2007
7214694	3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors Compounds of formula (I): wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP. ...	05/08/2007
7151175	Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suit...	12/19/2006
7148219	Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety th...	12/12/2006
7064123	Compounds and compositions as cathepsin inhibitors The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ...	06/20/2006
7041685	Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present i...	05/09/2006
7030116	Compounds and compositions as cathepsin inhibitors The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ...	04/18/2006
6992083	Benzoxazol derivatives The invention relates to compounds of formula wherein R is phenyl, unsubstituted or substituted by halogen or —CH2N(CH3)(CH2)nOCH3	01/31/2006
6977256	Compounds and compositions as cathepsin S inhibitors The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ...	12/20/2005
6897306	3-heterocyclylpropanohydroxamic acids Compounds of formula (I): and their salts, solvates, prodrugs, etc., wherein the substituents have the values mentioned herein, are Procollagen C-Proteinase (PCP) inhibitors and have utility in conditions mediated by P...	05/24/2005
6852719	Glucocorticoid receptor modulators The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocor...	02/08/2005
6730671	Compounds useful as reversible inhibitors of cathespin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes, for making such novel compounds.	05/04/2004
6617323	Amino-substituted compounds useful as inhibitors of IMPDH enzyme The present invention discloses compounds useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases, having the formula (I), ##STR1## wherein X is --C(O)--, --C(S)--, or --S(O)2 --; A is a...	09/09/2003
6608057	Compounds useful as reversible inhibitors of cathepsin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds ##STR1##...	08/19/2003
6576630	Compounds and compositions as protease inhibitors The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making....	06/10/2003
6566509	Multivalent macrolide antibiotics Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds at which bind to bacterial ribosomal RNA and/or to one or more proteins involved i...	05/20/2003
6395897	Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5 Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds. ##STR1##...	05/28/2002
6277872	Oxadiazoles, processes for their preparation and their use as medicaments The invention relates to oxadiazole derivatives of general formula (I) ##STR1## wherein X, Y, Z and R1 are defined as described in the specification and claims, processes for preparing them and their use as pharmaceutical compositions....	08/21/2001
6255304	Oxazolidinone antibacterial agents having a thiocarbonyl functionality The present invention provides compounds of Formula 1 ##STR1## or pharmaceutical acceptable salts thereof wherein A, G and R, are as defined in the claims which are antibacterial agents....	07/03/2001
6100259	Cannabinoid receptor modulators Novel pyrazole derivatives are provided which are cannabinoid receptor modulators. ##STR1##...	08/08/2000
6087359	Thioaryl sulfonamide hydroxamic acid compounds A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhi...	07/11/2000
6051572	Azetidine, pyrrolidine and piperidine derivatives A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT	04/18/2000
5965579	Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them The invention relates to compounds of the formula: ##STR1## Compounds of the above formula have a great affinity for the neurotensin receptors....	10/12/1999
5914351	Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a...	06/22/1999
5877316	Morpholine derivatives, compositions containing them and their use as therapeutic agents The present invention relates to compounds of formula (I), wherein R1 and R4 represent hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkyl...	03/02/1999
5854179	Sulfur-substituted phenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators Sulfur-substituted phenylsulfonylureas; processes for their preparation and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof ##STR1## in which R*, R1, R2, R3, X, Y, Z, W, n...	12/29/1998
5852011	Benzimidazole derivatives Disclosed are compounds represented by the following chemical formula (I) and pharmacologically acceptable salts thereof which are novel compounds useful as anticancer agents, antiviral agents or antimicrobial agents. ##STR1##...	12/22/1998
5840721	Imidazole derivatives as MDR modulators The present invention relates to polysubsituted imidazole having formula 1 ##STR1## These compounds are useful for restoring the sensitivity of multidrug resistant cells to cancer chemotherapeutic agents....	11/24/1998
5837702	4-arylamino-benzopyran and related compounds Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH2 --, --C(O)--, --O--, --S-- or --N(R8)-- where R8 is hydrogen, alkyl, haloalkyl, aryl, a...	11/17/1998
5801170	Heterocyclic biphenylylamides useful as 5HT1D antagonists A compound of formula (I) or a salt thereof: ##STR1## wherein P is a 5 to 7 membered heterocyclic ring selected from the group consisting of thienyl, furyl, pyrrolyl, triazolyl, diazolyl, tetrazolyl, imidazolyl, oxadiazolyl, isothiazolyl, isoxazolyl,...	09/01/1998
5665746	Mono- and bicyclic DNA gyrase inhibitors The present invention relates to a compound of the formula ##STR1## wherein X1, R1, R2, OP, R3, R4, R5, R6, and R0 are as described herein, and their pharmaceutically ...	09/09/1997
5589473	Mono- and bicyclic DNA gyrase inhibitors The present invention relates to a compound of the formula ##STR1## wherein X1, R1, R2, OP, R3, R4, R5, R6, and R0 are as described herein, and their pharmaceutically ...	12/31/1996
5403840	Inclusion complexes of N-ethoxycarbonyl 1-3-morpholino-sydnonimine or salts formed with cyclodextrin-derivatives, preparation thereof and pharmaceutical compositions containing the same The invention relates to inclusion complexes of N-ethoxycarbonyl-3-morpholino-sydnonimine or its salts formed with a cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same. The inclusion complex of N-ethoxycarbon...	04/04/1995
5356916	1,2,4-oxadiazole derivatives having monoamine oxidase B enzyme-inhibitory activity A 1,2,4-oxadiazole derivative is represented by the following general formula (I): ##STR1## wherein R1 represents a lower alkyl or cycloalkyl group, a lower alkyl group substituted with a halogen atom, a lower alkylamino group or a ph...	10/18/1994
5332742	Renin inhibitors A renin inhibiting compound of the formula: ##STR1## wherein R1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-l-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl; R2 is b...	07/26/1994
5225548	Indophenol dyes and thermal transfer thereof Indophenol dyes of the formula ##STR1## where X is nitrogen or the radical CH, Q is a five-membered heterocyclic radical, and K is a radical of an aniline, aminonaphthalene, aminoquinoline or aminothiazole derivative, and the radical A can be benzofused, ...	07/06/1993

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Class 544/138 - Oxadiazole ring (including hydrogenated)