Class 544/135 - Benzothiazoles (including hydrogenated)

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein a six-membered carbocyclic ring is ortho-fused
No. of patents: 164
Last issue date: 05/13/2008

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Number	Title	Issue Date
7371749	Benzothiazole derivatives The present invention relates to compounds of formulae IA and IB wherein R1 and R2 are each independently lower alkyl or —(CH2)m—O-lower alkyl, or together with t...	05/13/2008
7371748	Benzothiazole derivatives This invention relates to compounds of formula I wherein R1 and R2 are defined herein, or a pharmaceutically acceptable salt thereof.	05/13/2008
7348347	Substituted 4,5,6,7-tetrahydrobenzthiazol-2-ylamine compounds Substituted 4,5,6,7-tetrahydrobenzothiazol-2-ylamine compounds, a method for their production; pharmaceutical compositions comprising them, and methods of use for modulating biological functions and/or treating or inhibiting various medical conditions such as, e.g.,...	03/25/2008
7314872	Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides m...	01/01/2008
7304058	Carbamic acid esters of benzothiazoles The present invention relates to a compound of formula I wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the treatment of diseases relat...	12/04/2007
7285548	Urea substituted benzothiazoles The present invention relates to compounds of formula I wherein R1 and R2 are described herein, and their pharmaceutically acceptable salts thereof for the...	10/23/2007
7226940	Substituted heterocycles for the treatment of diabetes and other diseases The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymph...	06/05/2007
7205312	N-[4-(heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydrox...	04/17/2007
7141595	Amino benzothiazole compounds with NOS inhibitory activity The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are useful for treating stroke and n...	11/28/2006
7122545	Imidazo-benzothiazoles The invention relates to 2-imidazo-benzothiazoles of general formula wherein R1, R2, R3, R4, R5, R6, R7, R′, R″, X, R′″ and n a...	10/17/2006
7105514	Substituted indolealkanoic acids Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as metho...	09/12/2006
RE39265	Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound...	09/05/2006
7045518	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela...	05/16/2006
7019001	Substituted benzothiazole amide derivatives A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A2 receptor system comprising administering a compound of formula to a person in need of such treatment.	03/28/2006
6987184	Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related Isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2—, —SO—, ...	01/17/2006
6743788	Carbamate and oxamide compounds Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are ...	06/01/2004
6734179	Benzothiazoles The present invention relates to compounds of the formula wherein R1 and R2 are as described within. The compounds of formula I have been found to be adenosine receptor ligands. Specifically, the compounds of the present...	05/11/2004
6730671	Compounds useful as reversible inhibitors of cathespin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes, for making such novel compounds.	05/04/2004
6667307	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu...	12/23/2003
6624163	Benzothiazole derivatives The present invention relates to compounds of the formula ##STR1## wherein R1 and R2 are as defined herewithin. The compounds of formula I have been found to be adenosine receptor ligands. Specifically, the compounds of the present i...	09/23/2003
6608057	Compounds useful as reversible inhibitors of cathepsin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds ##STR1##...	08/19/2003
6596718	7-Morpholin-4yl-benzothiazole amide derivatives A compound of the formula ##STR1## A compound of formula I has a good affinity to the A2A receptor and is useful for the treatment of diseases mediated by this receptor....	07/22/2003
6562817	Tricyclic compound The present invention provides a compound of the formula (I): ##STR1## wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5- or 6-membered heterocycle which may fuse with benzene ring, ...	05/13/2003
6552199	Fluorescence dyes and their use as fluorescence markers The subject matter of the invention are new xanthene derivatives of the formula I, ##STR1## wherein R1,R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and X, Y, are as defined herein. The compounds according to the invention provide molecules that are--due...	04/22/2003
6548667	Sulfonamide derivative as a matrix metalloproteinase inhibitor The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonami...	04/15/2003
6403835	Acylation of an organic group over a zeolite The invention relates to the shape selective acylation of an organic compound. In particular, the invention describes a process for such acylation wherein the process comprises reducing the number of surface acid sites without dealuminations on at least a...	06/11/2002
6380188	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu...	04/30/2002
6362183	Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid comp...	03/26/2002
6251913	Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor Compounds of formula (I), ##STR1## wherein: n is 1 to 6; Het is a nitrogen containing ring fused to the benzene ring on two adjacent carbon atoms to form a bicyclic ring system which ring system may be optionally substituted; R1 is hydrogen, ...	06/26/2001
6214991	Substituted indolealkanoic acids Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as we...	04/10/2001
6201126	Isoindolenineamide dyestuffs Compounds of the formula (I) ##STR1## in which A represents N or a cyanomethylene radical, B represents S, O or NH and R1, R2, R3 and x have the meaning given in the description, are highly suitable for dyeing and printing high...	03/13/2001
6169085	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu...	01/02/2001
6124330	N-[4-(Heteroarylmethyl)phenyl]-heteroarylamines The present invention is concerned with compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6 alkyl or a...	09/26/2000
6043240	3-heteroaryl-1-pyrrolidinealkylamines and derivatives thereof and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. De...	03/28/2000
5985870	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu...	11/16/1999
5874432	Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula ##STR1## wherein: L is --O--, --S--, --SO-- or --SO2 --; m and n are each...	02/23/1999
5856349	2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof 4-R4 -R5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R4 -R5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in...	01/05/1999
5854263	1-(1,4-benzodioxanyl)alkyl!-3-(heteroaryl) pyrrolidines and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...	12/29/1998
5854243	3-heteroaryl-1-pyrrolidinealkylthiols and derivatives thereof and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...	12/29/1998
5783589	2-saccharinylmethyl aryl and arloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof 4-R4 -R5 -2-Saccharinylmethyl aryl and aryloxy acetates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R4 -R5 -2-halomethylsaccharin with an aryl or aryloxyacetic acid in the pre...	07/21/1998

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Class 544/135 - Benzothiazoles (including hydrogenated)