Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8080656 | Process for the preparation of aprepitant The present invention relates to a highly pure (2R,3S)-4-benzyl-3-(4-fluorophenyl)morpholin-2-yl 3,5-bis(trifluoromethyl)benzoate of Formula II, and a process for its preparation. The present invention further provides a process for preparation of Aprepitant of Form... | 12/20/2011 |
| 7915407 | Process for {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl) -morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically ... | 03/29/2011 |
| 7847095 | Process for 5-[[2(r)-[1(r)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(s)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3h-1.,2,4-triazol-3-one The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4 -tria-zol-3-one. This compound is useful as a substanc... | 12/07/2010 |
| 7807829 | Process for {3-[2()-[(1)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3()-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(tri-fluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically ... | 10/05/2010 |
| 7442716 | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to t... | 10/28/2008 |
| 7425555 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38. ... | 09/16/2008 |
| 7335653 | Bis-aryl sulfonamides Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls i... | 02/26/2008 |
| 7317007 | Benzothiazole derivatives with activity as adenosine receptor ligands The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor. ... | 01/08/2008 |
| 7304062 | Peroxisome proliferator activated receptor alpha agonists The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C | 12/04/2007 |
| 7288541 | Propylcarbamate derivatives as inhibitors of serine and cysteine proteases The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well as methods of using the same in the treatment of disorders, including ... | 10/30/2007 |
| 7285548 | Urea substituted benzothiazoles The present invention relates to compounds of formula I wherein R1 and R2 are described herein, and their pharmaceutically acceptable salts thereof for the... | 10/23/2007 |
| 7282499 | Sigma receptor inhibitors The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to some pyrazole derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy... | 10/16/2007 |
| 7279469 | Diaminotriazoles useful as inhibitors of protein kinases The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. ... | 10/09/2007 |
| 7279476 | Pyrazole-derived kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors having the formula: where B, R1, n, R3, Q, and R4 are described in the specification. The compounds are... | 10/09/2007 |
| 7226920 | Aminotriazole compounds useful as inhibitors of protein kinases The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various... | 06/05/2007 |
| 7208504 | Bicyclic inhibitors of hormone sensitive lipase Benzotriazoles of formula I in which R1 to R8 have the abovementioned meanings and process for their preparation are described. The compounds show an inhibitory effect on hormone-sensitive lipase. ... | 04/24/2007 |
| 7196082 | Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the us... | 03/27/2007 |
| 7160912 | Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them. The present invention also relates to a process for t... | 01/09/2007 |
| 7138420 | Substituted benzimidazole compounds Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit It... | 11/21/2006 |
| 7102001 | Process for preparing pyrrolotriazine The present invention provides a process for preparing compounds of formula (I) or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinas... | 09/05/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7045520 | Opioid receptor active compounds The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also pr... | 05/16/2006 |
| 6982264 | Substituted alcohols useful in treatment of Alzheimer's disease The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are u... | 01/03/2006 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6969697 | Substituted benzoylcyclohexenones The invention relates to novel substituted benzoylcyclohexenones of the formula (I), in which n, A, R1, R2, R3, R4, Y and Z are each as defined in the descriptio... | 11/29/2005 |
| 6956036 | 6-hydroxy-indazole derivatives for treating glaucoma Substituted 1-(α-alkyl-ethylamino)-1H-indazol-6-ols useful for lowering and controlling IOP and treating glaucoma are disclosed ... | 10/18/2005 |
| 6927233 | 5ht2 agonists for controlling IOP and treating glaucoma Compositions and methods for controlling intraocular pressure and treating glaucoma using 1-(2-aminopropyl)-indazol-6-ol are disclosed. ... | 08/09/2005 |
| 6914058 | Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotammers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceuti... | 07/05/2005 |
| 6900207 | N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activit... | 05/31/2005 |
| 6828315 | 1-Amino triazoloc4,3-a! quinazoline-5-ones and/or -5-thiones inhibiting phosphodiesterase IV The present invention relates to triazolo[4,3-a]quinazoline-5-ones and 5-thiones of Formula I and Formula II, whereby I and II are position isomers of group R on nitrogen 3 or 4. Optionally, the invention also relates to the racemic forms, isomers and pharmaceutical... | 12/07/2004 |
| 6787543 | Benzhydryl derivatives A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present in... | 09/07/2004 |
| 6723742 | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R1-R5 are as defined in the description. The compounds have useful pharmaceutical properties and are particularly activ... | 04/20/2004 |
| 6673939 | Process for the preparation of 1,2,4-triazolin-5-one derivatives The present invention relates to a process for the preparation of a compound of formula (I) wherein R represents hydrogen, C1-10 alkyl, haloC1-10 alkyl or aryl; which are useful intermediates in the preparation of morpholine derivati... | 01/06/2004 |
| 6638930 | Morpholine and thiomorpholine tachykinin receptor antagonists Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiov... | 10/28/2003 |
| 6630468 | Disubstituted pyrazolines and triazolines as factor Xa inhibitors The present application describes disubstituted pyrazolines and triazolines of formulae I and II: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of M1 and M2 maybe N and D may be a variety of N-containing gro... | 10/07/2003 |
| 6608059 | Fatty acid synthase inhibitors This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.... | 08/19/2003 |
| 6583142 | Polymorphic form of a tachykinin receptor antagonist This invention is concerned with a novel polymorphic form of the compound 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-phenyl)-ethoxy)-3-(S)-(4-fluoro)phe nyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylmorpholine which is a tachykinin receptor antagonist useful in t... | 06/24/2003 |
| 6544990 | Substituted quinolinecarboxamides as antiviral agents The present invention discloses disubstiuted 4-oxo-1,4-dihydro-3-quinolinecarboxamide derivatives. The compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 04/08/2003 |
| 6506747 | Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents 1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.... | 01/14/2003 |
| 6495697 | Silver halide color photographic lightsensitive material and novel pyrrolotriazole compound A silver halide color photographic lightsensitive material contains a coupler represented by formula (I) below in at least one layer on a support (in this formula, X represents a hydrogen atom or a group which can split off by a coupling reaction with an ... | 12/17/2002 |
