Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
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| Number | Title | Issue Date |
| 7427618 | Ethynyl derivatives as factor Xa inhibitors Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic di... | 09/23/2008 |
| 7371748 | Benzothiazole derivatives This invention relates to compounds of formula I wherein R1 and R2 are defined herein, or a pharmaceutically acceptable salt thereof. | 05/13/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7351719 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t... | 04/01/2008 |
| 7312215 | Benzimidazole C-2 heterocycles as kinase inhibitors Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer. ... | 12/25/2007 |
| 7300931 | Compositions for treating cell proliferation disorders The invention relates to compounds and methods for treating cell proliferation disorders. ... | 11/27/2007 |
| 7288251 | Antibodies to CD40 The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof.... | 10/30/2007 |
| 7282500 | Imidazole-2-carboxamide derivatives as Raf kinase inhibitors The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, use as Raf Kinase Inhibitors and treatment methods for neurotrau... | 10/16/2007 |
| 7276500 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings:... | 10/02/2007 |
| 7244731 | 6-Methylpyridine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same The present invention relates to 6-methylpyridine derivatives useful as an antiviral agent. More particularly, the present invention relates to novel 6-methylpyridine derivatives having an excellent inhibitory effect on replication of Hepatitis C virus (HCV), or pha... | 07/17/2007 |
| 7230017 | Dihydropyridinone derivatives The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failur... | 06/12/2007 |
| 7226921 | Compounds and compositions as cathepsin S inhibitors The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ... | 06/05/2007 |
| 7223760 | Substituted triazole compounds Novel substituted triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 05/29/2007 |
| 7211579 | NK-1 receptor antagonists The present invention relates to compounds of formula I wherein R is methyl; and R1 is 4-methyl-4-oxy-piperazin-1-yl; or R is CH2OH and R | 05/01/2007 |
| 7186724 | Heterocyclic substituted carbonyl derivatives and their use as dopamine Dreceptor ligands The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine... | 03/06/2007 |
| 7153815 | Insecticide containing hydrazone derivative as the active ingredient and novel hydrazone derivative A insecticide characterized by containing as active ingredient a hydrazone derivative of formula (I) wherein A and Q are an aryl or a heterocyclic group, W is oxygen atom, an aminylene, an alkylene group, an oxya... | 12/26/2006 |
| 7105513 | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals The present invention relates to acylated, heteroaryl-condensed cycloalkenylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of endothelial NO synthase, and methods of treatment comprising administeri... | 09/12/2006 |
| 7071332 | Indolinone derivatives as protein kinase/phosphatase inhibitors The present invention relates to certain 2-indolinone compounds which modulate the activity of protein kinases (“PKs”) and phosphatases. The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical co... | 07/04/2006 |
| 7041669 | 1,4-benzofused urea compounds useful in treating cytokine mediated diseases Disclosed are 1,4-disubstituted benzo-fused urea compounds of formula (I): wherein Ar, X, A, L, and Q of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes an... | 05/09/2006 |
| 7026339 | Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions contai... | 04/11/2006 |
| 7022695 | Thioether-substituted benzamides as inhibitors of Factor Xa Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding. ... | 04/04/2006 |
| 6943160 | Morpholine derivatives as antagonists of orexin receptors This invention relates to morpholine derivatives of formula (I) and their use as antagonists of orexin receptors. ... | 09/13/2005 |
| 6939867 | β3 agonists and uses thereof Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity, diabetes, hypertension, gastrointestinal hypo- or hyper-motility and ... | 09/06/2005 |
| 6932960 | N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted 3-hydroxy-4-pyridinones and/or their metal chelates. Use of N-substi... | 08/23/2005 |
| 6916933 | 4-pyridinyl-n-acyl-l-phenylalanines Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4. ... | 07/12/2005 |
| 6881735 | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically a... | 04/19/2005 |
| 6835832 | Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic co... | 12/28/2004 |
| 6831082 | Method of using soluble epoxide hydrolase inhibitors Disclosed are novel compounds of the formula Ia and methods of using soluble epoxide hydrolase (sEH) inhibitors of the formulas I and Ia for diseases related to cardiovascular disease. ... | 12/14/2004 |
| 6821972 | 3-heterocyclylpropanohydroxamic acid PCP inhibitors Compounds of formula (I): and their salts, solvates, hydrates and prodrugs are useful PCP inhibitors, processes for making the same, compositions comprising the same, and methods of treating a PCP-mediated condition or... | 11/23/2004 |
| 6759412 | Acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenyl amines and their use as pharmaceutical agents The present invention relates to compounds according to the general formula (I), wherein R1-R4 have the meanings given in the description, A is CH2, CHOH or CH—(C1-C3 | 07/06/2004 |
| 6750338 | Process for making 5-substituted pyrazoles This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors. ... | 06/15/2004 |
| 6734179 | Benzothiazoles The present invention relates to compounds of the formula wherein R1 and R2 are as described within. The compounds of formula I have been found to be adenosine receptor ligands. Specifically, the compounds of the present... | 05/11/2004 |
| 6689779 | Oxazolidinone derivatives and a process for the preparation thereof The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidin... | 02/10/2004 |
| 6660732 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/09/2003 |
| 6656933 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c... | 12/02/2003 |
| 6638930 | Morpholine and thiomorpholine tachykinin receptor antagonists Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiov... | 10/28/2003 |
| 6620811 | Isonicotin- and nicotinamide derivatives of benzothiazoles The present invention relates to compounds of the formula ##STR1## wherein R1, A and R are as described within. The compounds of the present invention have been found to be adenosine receptor ligands. Specifically, the compounds of the present invention h... | 09/16/2003 |
| 6608058 | 6-methylnicotinamide derivatives as antiviral agents The present invention relates to novel 6-methylnicotinamide derivatives and their pharmaceutically acceptable salts, the process for preparing them, and the pharmaceutical compositions containing said compounds as active ingredients. The 6-methylnicotinam... | 08/19/2003 |
| 6608052 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceut... | 08/19/2003 |
| 6599901 | Pyridone substituted benzothiazole derivatives The present invention relates to compounds of the formula ##STR1## wherein R is as defined herewithin. The compounds of formula I have a good affinity to the A2A receptor and therefore they may be used in the control or prevention of illnesses ... | 07/29/2003 |
