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| Number | Title | Issue Date |
| 7390804 | N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient An N-containing five-membered ring compound of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity aga... | 06/24/2008 |
| 7384943 | Substituted chroman derivatives The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives having the formula (I) wherein X is N; Y is NR2CH2, CH2 | 06/10/2008 |
| 7351720 | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity The present application describes modulators of chemokine receptor activity of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases, as well as auto... | 04/01/2008 |
| 7348324 | Cyclic amine compounds as CCR5 antagonists A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic ... | 03/25/2008 |
| 7342027 | 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof Provided are 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable salts thereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the same as an active ingredient, and processes for the preparation thereof. ... | 03/11/2008 |
| 7338956 | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals The present invention relates to acylamino-substituted heteroaromatic compounds of formula I, wherein R1, R2, R3, R4 and R5 and X are as defined herein, to pharmaceutic... | 03/04/2008 |
| 7332501 | Indol-3-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R... | 02/19/2008 |
| 7329656 | Arylthiobenzylpiperidine derivatives This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically accepta... | 02/12/2008 |
| 7317007 | Benzothiazole derivatives with activity as adenosine receptor ligands The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor. ... | 01/08/2008 |
| 7307090 | Piperidine derivatives useful as modulators of chemokine receptor activity The invention provides a compound of formula (I), wherein: T is C(O) or S(O)2; W is C(O) or S(O)2; X is CH2, O or NH; Y is CR5 or N; R1 is optionally substituted aryl or optionally substituted heterocyclyl; R | 12/11/2007 |
| 7304058 | Carbamic acid esters of benzothiazoles The present invention relates to a compound of formula I wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the treatment of diseases relat... | 12/04/2007 |
| 7291613 | Inhibitors of p38 kinase The invention is directed to methods to inhibit p38-α kinase using compounds comprising saturated heterocycles coupled to a fused ring system. ... | 11/06/2007 |
| 7288540 | Phenylalkynes Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4 | 10/30/2007 |
| 7285548 | Urea substituted benzothiazoles The present invention relates to compounds of formula I wherein R1 and R2 are described herein, and their pharmaceutically acceptable salts thereof for the... | 10/23/2007 |
| 7279472 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds | 10/09/2007 |
| 7265121 | Chemical compounds Compounds of formula (I) in which R1, R2 and X4 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders. ... | 09/04/2007 |
| 7259158 | Naphthaline derivatives as H3 inverse agonists The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are usef... | 08/21/2007 |
| 7253169 | Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ... | 08/07/2007 |
| 7253186 | N-substituted piperidine derivatives as serotonin receptor agents Disclosed herein are compounds of Formula I, or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof. Also disclosed are methods of inhibiting an activity of a monoamine receptor comprising contac... | 08/07/2007 |
| 7238691 | Piperidine derivatives and their use as modulators of chemokine (especially CCR3) activity The invention provides a compound of formula (I): T is C(O) or S(O)2; W is CH2, (CH2)2, CH(CH3), CH(CH3)O or cyclopropyl; X is O, CH2, C(O), S, S(O), S(O)2 or NR3; m i... | 07/03/2007 |
| 7211576 | Diaminothiazoles Novel diaminothiazoles of formula (I): are discussed. These compounds selectively inhibit the activity of Cdk4 and are thus useful in the treatment or control of cancer, in particular, the treatment or control of... | 05/01/2007 |
| 7186718 | Piperidinyl-morpholinyl derivatives as modulators of chemokine receptor activity The invention provides compounds of general formula (I), in which m, n, Z1, Z2, R1, R2, R3, R4 and R5 are as defined in the specification; processes for their preparation; pharmaceutical co... | 03/06/2007 |
| 7186719 | Antibacterial agents Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1–C6 alkyl or C1–C6 alkyl substit... | 03/06/2007 |
| 7186827 | Dipeptide synthesis Disclosed are processes of making dipeptide compounds of formula(I) as further described in the detailed description section: ... | 03/06/2007 |
| 7122545 | Imidazo-benzothiazoles The invention relates to 2-imidazo-benzothiazoles of general formula wherein R1, R2, R3, R4, R5, R6, R7, R′, R″, X, R′″ and n a... | 10/17/2006 |
| 7115610 | Substituted heterocyclic compounds Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atri... | 10/03/2006 |
| 7115635 | Benzylpiperidine compound The object of the present invention is to provide a compound having a treatment effect based on a chemokine inhibitory activity, which is satisfactory as a pharmaceutical product for oral administration. The present inventors have found that the following ben... | 10/03/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7101909 | Calcium channel drugs and uses Novel multibinding compounds are disclosed. The compounds of this invention comprise 2–10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel, thereby modulating the biological activities... | 09/05/2006 |
| 7071180 | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2... | 07/04/2006 |
| 7071191 | Non-imidazole aryloxypiperidines Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions. ... | 07/04/2006 |
| 7067533 | Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof The present invention relates to an aminophenoxyacetamide derivative of the formula (I): wherein R1 to R4 are, independent from each other, a hydrogen atom or an optionally substituted alkyl... | 06/27/2006 |
| 7064136 | Compounds A compound having the general formula and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds. ... | 06/20/2006 |
| 7064124 | NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient A NF-κB inhibitor represented by the following formula (I) is provided: ... | 06/20/2006 |
| 7041681 | Compounds as opioid receptor modulators This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders. ... | 05/09/2006 |
| 7034042 | N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33 receptor antagonists Compounds of formula (I) in free or salt form, where Ar1 is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C1–C8-alkyl optionally substituted by cyano or halogen, Ar2 is phenyl op... | 04/25/2006 |
| 7019001 | Substituted benzothiazole amide derivatives A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A2 receptor system comprising administering a compound of formula to a person in need of such treatment. | 03/28/2006 |
| 6992083 | Benzoxazol derivatives The invention relates to compounds of formula wherein R is phenyl, unsubstituted or substituted by halogen or —CH2N(CH3)(CH2)nOCH3 | 01/31/2006 |
| 6958331 | Bradykinin receptor antagonists The invention relates to sulfonyl amine derivatives of formula IA wherein R5A, X1, X2, R9 and R10 are as defined herein, which derivatives are useful as bradykinin... | 10/25/2005 |
| 6956037 | Benzamide derivatives for the treatment of diseases mediated by cytokines The invention concerns amide derivatives of Formula (I), wherein R3 is (1-6C)alkyl or halogeno; m is 1-3 and R1 is selected from substituents such as: (A) hydroxy, halogeno, (1-6C)alkyl, (1-6C)alkoxy, aryl, heteroaryl and heterocyclyl; and (B) ... | 10/18/2005 |
