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| Number | Title | Issue Date |
| 7442710 | Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R... | 10/28/2008 |
| 7435726 | Compositions and methods for the treatment of cancer This invention relates to compositions comprising thalidomide and another anti-cancer drug which can be used in the treatment or prevention of cancer. Preferred anti-cancer drugs are topoisomerase inhibitors. A particular composition comprises thalidomide, or a phar... | 10/14/2008 |
| 7432276 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 10/07/2008 |
| 7423045 | ABCA1 elevating compounds The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The inve... | 09/09/2008 |
| 7411064 | 1-Heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor ... | 08/12/2008 |
| 7405211 | Therapeutic morpholino-substituted compounds Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as othe... | 07/29/2008 |
| 7393955 | Isoquinoline derivatives and methods of use thereof The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described. ... | 07/01/2008 |
| 7388016 | Dibenzonaphthyridine derivatives and methods of use thereof The present invention relates to Dibenzonaphthyridine Derivatives, compositions comprising an effective amount of a Dibenzonaphthyridine Derivative and methods for treating or preventing a proliferative disorder, comprising administering to a subject in need thereof... | 06/17/2008 |
| 7381722 | Tetracyclic amino and carboxamido compounds and methods of use thereof The present invention relates to Tetracyclic Amino Compounds and Tetracyclic Carboxamido Compounds, compositions comprising an effective amount of a Tetracyclic Amino Compound or a Tetracyclic Carboxamido Compound and methods for treating or preventing an inflammato... | 06/03/2008 |
| 7354918 | Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof The invention relates to novel derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol, having formula (I) in which R represents a radical —AR′ wherein A represents a heteroatom and R′ represents a group selected fr... | 04/08/2008 |
| 7351830 | Pancratistatin cyclic phosphate prodrugs and phenpanstatin cyclic phosphate prodrugs Selective phosphorylation of phenpanstatin (3a) with tetrabutylammonium dihydrogen phosphate and dicyclohexyl-carbodiimide in pyridine followed by cation exchange chromatographic procedures was found to provide an efficient mute to a new series (3 | 04/01/2008 |
| 7320984 | Remedies or preventives for urinary frequency or urinary incontinence and morphinan derivatives having nitrogen-containing heterocyclic group The invention provides a morphinan derivative of the Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y ... | 01/22/2008 |
| 7273865 | Thiazolopyridine The present invention relates to compounds of formula I wherein R1 and R2 are described hereinbelow. These compounds have high affinity to A2A receptors and good selectivity to A | 09/25/2007 |
| 7268143 | Isoquinoline derivatives and methods of use thereof The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described. ... | 09/11/2007 |
| 7259165 | Heterocyclyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 08/21/2007 |
| 7217709 | Tetracyclic benzamide derivatives and methods of use thereof The invention relates to Tetracyclic Benzamide Derivatives; compositions comprising a Tetracyclic Benzamide Derivative; and methods for treating or preventing an inflammatory disease, a reperfusion disease, an ischemic condition, renal failure, diabetes, a diabetic ... | 05/15/2007 |
| 7211572 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt th... | 05/01/2007 |
| 7205385 | Polymerization method for the synthesis of polypeptide imaging agents A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method... | 04/17/2007 |
| 7149749 | Method of inserting and deleting leaves in tree table structures A technique is provided to either insert or delete a leaf in a Patricia tree having a direct table and a plurality of PSCB's which decode portions of the pattern of a leaf in the tree without shutting down the functioning of the tree. A leaf having a pattern is iden... | 12/12/2006 |
| 7129248 | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ... | 10/31/2006 |
| 7115619 | N, N-disubstituted quino[4,3,2-kl]acridinium salts as therapeutic agents The present invention pertains to certain N8,N13-disubstituted quino[4,3,2-kl]acridinium salts of formula (Q−) which inhibit telomerase wherein: p is an integer from 0 to 4; q is an integer from 0 to 3; r is an integer from 0 to 4;... | 10/03/2006 |
| 7064124 | NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient A NF-κB inhibitor represented by the following formula (I) is provided: ... | 06/20/2006 |
| 7064202 | Camptothecin intermediates and prodrugs and methods of preparation thereof The present invention relates to novel intermediates and prodrugs of camptothecin and related analogs. ... | 06/20/2006 |
| 7057039 | 1-heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 06/06/2006 |
| 6956035 | Isoquinoline derivatives and methods of use thereof The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described. ... | 10/18/2005 |
| 6946556 | Preparation of opioid analgesics by a one-pot process A one-pot process for preparing opioid analgesics such as hydrocodone, hydromorphone, and analogues thereof by reacting codeine, morphine, and analogues thereof with hydrogen in a solvent system of benzophenone and neutral solvent in the presence of a metal catalyst... | 09/20/2005 |
| 6933302 | Nitrogen-based homo-camptothecin derivatives (20) esters of camptothecin analogs are provided. The compounds are (20) esters of an aminoalkanoic acid or an imidoalkanoic acid and homocamptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the homocamptothecin ring. The compounds ... | 08/23/2005 |
| 6927292 | Tricyclic epoxides The invention relates to compounds of Formula (1), in which the substituents and symbols have the meanings indicated in the description. The compounds are valuable intermediates for the preparation of pharmaceutical active compounds. ... | 08/09/2005 |
| 6914067 | Compositions and methods for the treatment of colorectal cancer This invention relates to compositions comprising thalidomide and irinotecan, which can be used in the treatment or prevention of colorectal cancer. The invention also relates to methods of treating or preventing colorectal cancer which comprise the administration o... | 07/05/2005 |
| 6906063 | Platelet ADP receptor inhibitors Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives whi... | 06/14/2005 |
| 6894041 | Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: | 05/17/2005 |
| 6869945 | Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: | 03/22/2005 |
| 6838456 | Condensed pyridoindole derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 01/04/2005 |
| 6828319 | Substituted indeno[1,2-c]isoquinoline derivatives and methods of use thereof The invention provides novel classes of substituted Indeno[1,2-c]isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described. ... | 12/07/2004 |
| 6825208 | Tetrahydroquinoline derivatives as antithrombotic agents This invention relates generally to tetracyclic tetrahydroquinoline compounds, and analogues thereof, and pharmaceutically acceptable salt forms thereof, which are selective inhibitors of serine protease enzymes, especially factor VIIa; pharmaceutical compositions c... | 11/30/2004 |
| 6809096 | Phenanthroline-7-one derivatives and their therapeutic uses A pharmaceutical composition including an efficient amount of a compound selected among the compounds of formulae (I) and (Ia). The compounds have interesting cytotoxic properties leading to a therapeutic use as antitumoral medicines. | 10/26/2004 |
| 6642248 | Benzo[b]pyrano[3,2-h]acridin-7-one compounds A compound selected from those of formula (I): ##STR1## wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, --ORa, --NRaRb, --NRa--C(O)--T1, --O--C(O)--T | 11/04/2003 |
| 6605610 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such co... | 08/12/2003 |
| 6602867 | Triazole compounds with dopamine-D3-receptor affinity Triazole compounds of the following formula ##STR1## where R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 rece... | 08/05/2003 |
| 6545011 | Substituted 4,9-dihydrocyclopenta[imn]phenanthridine-5-ones, derivatives thereof and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.... | 04/08/2003 |
