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| Number | Title | Issue Date |
| 5061311 | Substituted triazolinone herbicides and plant growth regulators Novel herbicides and plant growth regulants of the formula ##STR1## in which R1 represents hydrogen alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, alkoxyalkyl, alkoxy, cycloalkylalkyl or cycloalkyl, or represents... | 10/29/1991 |
| 5051504 | Doubled triphenylmethane dyes having bis acylpiperazine linkage Triphenylmethane dyes of the formula ##STR1## where each R1 is independently of the others hydrogen or substituted or unsubstituted C1 -C6 -alkyl, or two R1 radicals together with the nitrogen atom joining ... | 09/24/1991 |
| 5047406 | Substituted cyclohexanols as central nervous system agents Substituted cyclohexanols and cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminer... | 09/10/1991 |
| 5043443 | Aminomethyloxooxazolidinyl arylbenzene derivatives Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as (l)-N-{3-[4- (4'-pyridyl)phenyl]-2-oxooxazolidin-5-ylmethyl}acetamide, possess useful ... | 08/27/1991 |
| 5039722 | Piperidine-triazine compounds for use as stabilizers for organic materials The new compounds of formula (I) ##STR1## in which R1 is e.g. hydrogen or methyl, R2 is e.g. a group --OR5 or ##STR2## in which R5 is e.g. 2,2,6,6-tetramethyl-4-piperidyl or 1,2,2,6,6-pentamethyl-... | 08/13/1991 |
| 5034390 | Pyridyl-and pyrmidyl-piperazines useful for the treatment of mental disorders The present invention concerns novel compounds of the general formula; ##STR1## wherein R1 is halogen or hydrogen and R2 is halogen; X is either oxygen, sulfor or methylene R3 and R4 are the same or different an... | 07/23/1991 |
| 5026702 | Morpholines and morpholine-N-oxides and pharmaceutical compositions containing these compounds The invention relates to new morpholines and morpholine-N-oxides of formula ##STR1## wherein the substituents are defined hereunder, which compounds have valuable pharmacological properties, namely an effect on the metabolism, preferably the effect o... | 06/25/1991 |
| 5023258 | Triazole antifungal agents The invention provides triazole antifungal compounds of the formula: ##STR1## wherein R is either (a) a phenyl group optionally substituted with 1 to 3 substituents, each selected independently from halo and CF3 ; or (b) a 5-chloropyridin-2-yl ... | 06/11/1991 |
| 5021420 | Derivatives of (AZA)naphthalenesultam, their preparation and compositions containing them This invention relates to a compound ##STR1## in which R1 represents a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or a... | 06/04/1991 |
| 5013732 | 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles 3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or 3-cycloalkylcarbonylindole with an aminoalkyl halide in the presence of an ac... | 05/07/1991 |
| 5011925 | Morpholinoamido EDTA derivatives Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with aminoalkylamide derivatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetraacetic acid ("EDTA") or other polyaminocarboxylic or cyclic polyaminocar... | 04/30/1991 |
| 5001160 | 1-aryl-1-hydroxy-1-substitute d-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders Compounds are disclosed having the formula: ##STR1## in which R1 is a C1 l to C12 alkyl, said alkyl being straight or branched chain, saturated or unsaturated, monosubstituted or unsubstituted, said substituents being... | 03/19/1991 |
| 4988809 | 2-pyrimidinyl-1-piperazine derivatives, processes for their preparation and medicaments containing them The invention relates to substituted 2-pyrimidinyl-1- piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of... | 01/29/1991 |
| 4977265 | Quinoline derivatives Tetracyclic compounds of the formula ##STR1## wherein R1, R2, X, Y, Z and n are as hereinafter described, and salts thereof, prepared starting from corresponding tricyclic compounds, are described. The compounds I and some of th... | 12/11/1990 |
| 4968714 | Fungicidal substituted 3-amino-2-pyrazolin-5-ones, compositions and use Fungicidal substituted 3-amino-2-pyrazolin-5-ones of the formula ##STR1## in which R1 represents unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl or alkinyl, or unsubstituted or substituted cycloalkyl or cycloalkeny... | 11/06/1990 |
| 4968706 | Ethers and thioethers having therapeutical activity, their preparation and pharmaceutical compositions containing them Compounds of formula I ##STR1## wherein Ar is an optionally substituted phenyl ring; B is a single bond, a group --(CH2 OCH2)n being n=1 or 2, a 2,4-disubstituted-1,3-dioxolane ring or a 2,4-disubstituted-1,3-thioxola... | 11/06/1990 |
| 4960777 | Heteroaryloxy-ଲ-carboline derivatives, their preparation and their use as medicinal agents Heteroaryloxy-ଲ-carboline derivatives of general Formula I ##STR1## wherein R1 is an optionally substituted heteroaryl residue, R2 is hydrogen, lower alkyl or lower alkoxyalkyl, X is a COOR3 -group wherein R3 m... | 10/02/1990 |
| 4960776 | 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides Novel 4-aryl-N-[2-(dialkylamino and heterocyclicamino)alkyl]-1-piperazinecarboxamides of the formula: ##STR1## wherein B is oxygen or sulfur; Ar is selected from ##STR2## or 2, 3 or 4-pyridyl; X is selected from hydrogen, halogen, loweralkyl, ... | 10/02/1990 |
| 4957921 | Substituted cyclohexanols as central nervous system agents Substituted cyclohexanols are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agen... | 09/18/1990 |
| 4948796 | Piperazine derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient A piperazine derivative represented by the following formula or a salt thereof: ##STR1## which is useful for curing cerebro-vascular disease and post-cerebro-vascular disease.... | 08/14/1990 |
| 4948795 | Pyridylthiazolidine carboxamide derivatives and their intermediates and production of both This invention provides pyridylthiazolidine carboxamide derivative shown by general formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A1 is a single bond, carbonyl group or lower alkylene group which may include a... | 08/14/1990 |
| 4940710 | 7-(substituted)piperaziny l-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids 7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infec... | 07/10/1990 |
| 4937242 | 1,4-dihydropyridine derivatives and pharmaceutical composition thereof 1,4-Dihydropyridine derivatives of the general formula: ##STR1## wherein X1 and X2 independently represent hydrogen, fluoromethyl, fluoromethoxy, halogen, cyano, or nitro; R1 represents a lower alkyl; R2 re... | 06/26/1990 |
| 4937245 | Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation A compound having the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein all the symbols are defined in the specification; having valuable pharmaceutical properties, useful for the treatment of mental disorders, such as ... | 06/26/1990 |
| 4937343 | 2-pyrimidinyl-1-piperazine derivatives The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of ... | 06/26/1990 |
| 4935419 | Novel 1-piperazinecarboxamide derivatives A series of 1-piperazinecarboxamide derivatives of the following formula: ##STR1## The compounds of the present invention are neuropharmacological agents intended for the treatment of mental disorders, such as psychoses and depression.... | 06/19/1990 |
| 4933338 | Benzimidazolesulfonamides and their application as drugs Benzimidazole-2-sulfonamide and imidazopyridine-2-sulfonamide derivatives corresponding to the general formula I: ##STR1## and their pharmaceutically acceptable salts, especially those of the formula in which: Z1 to Z4 represent... | 06/12/1990 |
| 4933345 | Isoxazole-ଲ-carboline derivatives ଲ-Carbolines of general Formula I ##STR1## wherein Y represents the residue ##STR2## and Ra and Rb, being identical or different, mean respectively hydrogen, C1-6 -alkoxy, phenyl, C3-7 -cyclo-al... | 06/12/1990 |
| 4931443 | Piperazine compound and pharmaceutical use thereof A piperazine compound represented by the general formula: ##STR1## (wherein each of the symbols is as defined above) or a pharmaceutically acceptable acid addition salt thereof, and pharmaceutical uses thereof as well as intermediates thereof are dis... | 06/05/1990 |
| 4914227 | Certain intermediate 3-carbamoyloxyalkyl propiolic acid derivatives A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: ##STR1## which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: ##ST... | 04/03/1990 |
| 4914093 | Pyridazinone derivatives, their preparation and use Compounds of formula (I): ##STR1## (wherein Q is oxygen or sulfur, the dotted line is a single or double bond, A is alkylene, and R1 -R5 are a variety of atoms or organic groups) have excellent ability to potentiate myocardial c... | 04/03/1990 |
| 4912107 | Pyrrolocarbazole derivatives, compositions containing them, and methods for using them The invention concerns new pyrrolocarbazole derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing these for the inhibition of protein kinases, such as protein kinase C, and thus for the prevention and/or t... | 03/27/1990 |
| 4894386 | Aliphatic carboxamides This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z--Y--X< is selected from >C.dbd.CH--NN--CH.dbd.CC.dbd.N--N< and >N--N.dbd.C< and the other radicals have the meanings defined in the fo... | 01/16/1990 |
| 4889857 | Quinolonecarboxylic acid compounds and pharmaceutical use thereof A quinolonecarboxylic acid compound of the formula: ##STR1## wherein R1 is an alkyl group, a cycloalkyl group, a haloalkyl group, an alkenyl group, mono- or di-alkylamino groups, a phenyl group or a phenyl group substituted by one to three... | 12/26/1989 |
| 4888433 | Process for the preparation of optically active alpha-arylalkanoic acids and novel intermediates thereof A new enantioselective process is described for preparing optically active alpha-arylalkanoic acids by: (a) halogenation on the aliphatic carbon atom alpha to the ketal group, of ketals of formula ##STR1## in which Ar represents an aryl, optionally ... | 12/19/1989 |
| 4886809 | Carbostyril derivatives and salts thereof Novel carbostyril derivatives and salts thereof having useful pharmacological activities such as myocardial contraction increasing activity (positive inotropic activity), coronary blood flow increasing activity, hypotensive activity, activity for inhibiti... | 12/12/1989 |
| 4885294 | 2-aryl-3-(substituted piperazinyl)-1-(1H-1,2,4-triazolyl)propanol-2-ol antifungal agents An antifungal agent of the formula: ##STR1## wherein R is phenyl group which may be substituted by 1 to 3 substituents each independently selected from halo and CF3 ; R1 is either (a) a phenyl group substituted by a group of the... | 12/05/1989 |
| 4883870 | Piperidine-triazine compounds for use as stabilizers for organic materials The compounds of the formula (I) ##STR1## in which R1 is C1 -C8 -alkyloxy, allyloxy, allylamino, di(C1 -C4 -alkyl)amino, diallylamino, a 5-membered to 7-membered nitrogen containing heterocyclic ... | 11/28/1989 |
| 4883797 | Derivatives of piperazine, method for making the same Derivatives of piperazine having the general formula ##STR1## wherein R1 is benzhydryl or cinnamyl and R2 is selected from the group consisting of ##STR2## --(CH2)3 --R8, --CH2 NH... | 11/28/1989 |
| 4877803 | Bis-dioxopiperazine derivatives and pharmaceutical compositions containing the same Novel bis-dioxopiperazine derivatives represented by the following formula (I) and having a broader antitumor spectrum as well as pharmaceutical compositions containing the compounds as antitumor active components: ##STR1## wherein R1 repr... | 10/31/1989 |
