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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 7705145 | Process for the preparation of 4-(3′-chloro-4′-fluoroanilino) -7-methoxy-6-(3-morpholinopropoxy) quinazoline Chemical processes and intermediates useful in the manufacture of the quinazoline derivative 4-(3′-chloro-4′-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline, in particular processes for the manufacture of 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydro... | 04/27/2010 |
| 7429585 | Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups The present invention relates to compounds of the general formula IC wherein R2, R′, R″, R3, R6, X1 and X1′ are as defined here... | 09/30/2008 |
| 7427616 | Condensed pyridines and pyrimidines with tie2 (TEK) activity A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G ... | 09/23/2008 |
| 7402580 | Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.). Because of inhibiting poly(ADP-ribose)polymerase, ... | 07/22/2008 |
| 7399761 | Phthalazine derivatives with angiogenesis inhibiting activity The invention relates to new phthalazine derivatives of formula (I), wherein R1 and R2: a) are independently in each case a lower alkyl; b) together form a bridge of subformula (I*), wherein the bond is achieved via the two terminal C atoms and... | 07/15/2008 |
| 7335667 | Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-4-yl-amines as Janus kinase inhibitors The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related ... | 02/26/2008 |
| 7332493 | Substituted bicyclic derivatives for the treatment of abnormal cell growth The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m a... | 02/19/2008 |
| 7329655 | Nitrogenous heterocyclic compounds The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to ... | 02/12/2008 |
| 7317009 | Pyrrolopyridazine derivatives The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE... | 01/08/2008 |
| 7304059 | Substituted quinazolin-4-ylamine analogues Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activati... | 12/04/2007 |
| 7288651 | Preparation of quinoxaline compounds Certain methods are disclosed that are useful in the preparation of CCK2 active amidophenyl-sulfonylamino-quinoxaline compounds of the formula: wherein R1, R2, Ra and Rb | 10/30/2007 |
| 7285557 | Pyrimidinones as melanin concentrating hormone receptor 1 A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided ... | 10/23/2007 |
| 7278288 | Method and device for transferring a workpiece Aspects of the invention relate to a method and a device for transferring workpieces. In the method, at least one first handling device positions and/or securely holds at least one workpiece in a working region of a shaping machine, and, in at least one shaping proc... | 10/09/2007 |
| 7262201 | Quinazoline derivatives The invention relates to the use of compounds of the formula I: wherein: ring C is a 5-6 membered heterocyclic moiety; Z is —O—, —S—, or —CH2—; R1 is hydrogen, C1-4alk... | 08/28/2007 |
| 7243522 | Method and device for transferring a workpiece Aspects of the invention relate to a method and a device for transferring workpieces. In the method, at least one first handling device positions and/or securely holds at least one workpiece in a working region of a shaping machine, and, in at least one shaping proc... | 07/17/2007 |
| 7226923 | Phthalazinone derivatives Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, p... | 06/05/2007 |
| 7205309 | Quinazoline derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3 and A have the significance given in the specification are provided. The... | 04/17/2007 |
| 7192949 | Substituted bicyclic pyrimidinones as a mitotic kinesin KSP inhibitors The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions wh... | 03/20/2007 |
| 7189715 | Compositions comprising zopiclone derivatives and methods of making and using the same The invention is directed to racemic and stereomerically pure compounds of Formula 3: and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation. ... | 03/13/2007 |
| 7186710 | Phthalazinones The compounds of formula I in which R1, R2, R3, R4 and R5 have the meanings as given in the description are PDE4/7 inhibitors. ... | 03/06/2007 |
| 7153854 | Pyrrolopyridazine derivatives The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE... | 12/26/2006 |
| 7138398 | Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of formula (I) wherein R1, R2 and R3 have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the treatment and prophylaxis of diseases, for exampl... | 11/21/2006 |
| 7132419 | Pharmaceutical compounds A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I) wherein each of R1 to R4, which are the same or different, is selected from hydrogen, halogen, hydroxyl, C | 11/07/2006 |
| 7115615 | Quinazoline derivatives The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparat... | 10/03/2006 |
| 7115742 | Process for the preparation of triethylenediamine (TEDA) from ethylenediamine A process for the preparation of triethylenediamine (TEDA) by reaction of ethylenediamine (EDA) in the presence of a zeolite catalyst, wherein the zeolite catalyst contains one or more metals M in oxidation states II, III or IV as oxides. The desired molar ratio of ... | 10/03/2006 |
| 7098330 | Pyrazolylamine substituted quinazoline compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula III: wherein Ring D is a 5–7 membered monocyclic ring or 8–10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R... | 08/29/2006 |
| 7081461 | Quinazoline compounds and pharmaceutical compositions containing them The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, NH or NR8 where R8 is hydrogen or C1-6alkyl; | 07/25/2006 |
| 7056917 | Drug efflux pump inhibitor A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 ... | 06/06/2006 |
| 7045526 | Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of formula I: wherein R1, R2, and R3 have the meanings indicated in the specification, which are valuable pharmaceutical active compound... | 05/16/2006 |
| 7030112 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders Disclosed are pyrrolopyridazine compounds of the formula, wherein the substituents are defined herein, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and ... | 04/18/2006 |
| 7022696 | Piperazino-derivatives and their use as PDE4 inhibitor The compounds of formula I in which R1, R2, R3, A, X, s and R9 have the meanings as given in the description are novel effective PDE4 inhibitors. ... | 04/04/2006 |
| 7019011 | Aminoindazole derivatives as medicaments and pharmaceutical compositions including them The present invention relates to novel derivatives of general formula (I) in which R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or heteroar... | 03/28/2006 |
| 6977255 | Therapeutic morpholino-substituted compounds Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as othe... | 12/20/2005 |
| 6942956 | Process of transferring transferable protection overcoat to a dye-donor element A process of transferring a protection layer from a dye-donor receiver after thermal dye transfer. In one embodiment, the transferable protection layer contains inorganic particles, a polymeric binder, organic particles and an organic gloss-enhancing agent that enha... | 09/13/2005 |
| 6924284 | PARP inhibitors The present invention provides compounds comprising a bicyclic aryl moiety, such as 2H-phthalazin-1-one or derivatives thereof, compositions comprising the same, and methods for producing and using the same. In particular, the present invention provides compounds of... | 08/02/2005 |
| 6900220 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is carbon or nitrogen, Y is carbo... | 05/31/2005 |
| 6897213 | Heterocycles as cholecystokinin (CCK) ligands Novel quinazolinone derivatives with good binding affinity for the CCK-A and CCK-B receptors, pharmaceutical compositions containing them and methods of using them are taught. The compounds are useful agents to suppress appetite, reduce gastric acid secretion, and t... | 05/24/2005 |
| 6890924 | Substituted bicyclic derivatives for the treatment of abnormal cell growth The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R5, R11, m and p a... | 05/10/2005 |
| 6864259 | Antibacterial agents The present invention provides compounds of Formula (I): wherein R1-R6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as a... | 03/08/2005 |
| 6787650 | Urea compounds, process for producing the same and use thereof A compound of the formula: [wherein R1 is a hydrocarbon group which may be substituted; R2 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substitu... | 09/07/2004 |
