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| Number | Title | Issue Date |
| 7268138 | Compounds, methods and pharmaceutical compositions for inhibiting PARP The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein. | 09/11/2007 |
| 7235554 | 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments The invention provides compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 ... | 06/26/2007 |
| 7223758 | Pyridazine derivative, pharmaceutical composition thereof, its pharmaceutical use, and process for its preparation The invention relates to a pyridazine derivative of formula (I), wherein the variables are as defined herein, pharmaceutical composition thereof, process for its preparation, and its pharmaceutical use. ... | 05/29/2007 |
| 7223756 | Quinazoline compounds with therapeutic use The invention concerns the use of the quinazoline derivatives of Formula (I) wherein each of m, R1, Z, n and R3 have any of the meanings defined in the description in the manufacture of a medicament for use in the prevention or treatment of T c... | 05/29/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7109194 | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use The invention concerns compounds of general formula (I), wherein: X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1–C4)alkyl group; R2 and R3, represent each, independently of eac... | 09/19/2006 |
| 7109195 | Hexacyclic compounds and their therapeutic use The present invention relates to hexacyclic compound of the formula [1], wherein Z, R3 and R4 are as identified therein, and pharmaceutically acceptable salts thereof. These compounds are us... | 09/19/2006 |
| 7067655 | Adenosine A2a receptor antagonists Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, cycloalkenyl, or heteroaryl; X is alkylene or —C(O)CH2 | 06/27/2006 |
| 7064204 | Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use New compounds having a tricyclic pyrazolotriazolopyrimidine ring structure are provided and methods of using those compounds for a variety of therapeutic indications. ... | 06/20/2006 |
| 7037916 | Pyrimidine derivatives as IL-8 receptor antagonists Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q... | 05/02/2006 |
| 7034016 | 8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives 8-phenyl-6,9-dihydro-[1,2,4]triazolo[3,4-i]purin-5-one derivatives of formula (I): or a pharmaceutically acceptable salt thereof processes for their preparation, pharmaceutical compositions containing them and their use... | 04/25/2006 |
| 7005430 | Fused purine derivatives A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a sub... | 02/28/2006 |
| 6977255 | Therapeutic morpholino-substituted compounds Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as othe... | 12/20/2005 |
| 6964960 | Indoloquinazolinones The invention provides compounds of formula (I) wherein R is as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals, for use in the treatment of any state associated with high levels of activeted PARP. ... | 11/15/2005 |
| 6946461 | Imidazolophthalazine derivatives as ligands for GABAA receptors A class of substituted imadazolo[2,1-a]phthalazine derivatives as ligands for GABAA receptors of formula I: which are partial or full inverse agonists of an α5 receptor subunit while being relatively free o... | 09/20/2005 |
| 6933294 | Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R1, R2, and R3 are hydrogen, hal... | 08/23/2005 |
| 6916811 | Adenosine A2a receptor antagonists Disclosed herein are compounds having the structural formula A including pharmaceutically acceptable salts or solvates of said compound, wherein X, Y, Q and R are as defined in the specification; pharmaceutical composi... | 07/12/2005 |
| 6825194 | Hexacyclic compounds The present invention relates to hexacyclic compound of the formula [1], wherein Z, R3 and R4 are as identified therein, and pharmaceutically acceptable salts thereof. These compounds are useful i... | 11/30/2004 |
| 6765006 | Substituted quinazolines and analogs and the use thereof The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hyp... | 07/20/2004 |
| 6750214 | Quinoline and quinazoline compounds useful in therapy The invention provides compounds of formula (I), wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents H or C1-6 alkoxy optional... | 06/15/2004 |
| 6740650 | Heterocyclic cytotoxic agents The invention provides compounds of formula I: wherein R1-R8 and A-G have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also prov... | 05/25/2004 |
| 6730681 | Triazolo-pyrimidine derivatives as ligands for gaba receptors A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-α]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA... | 05/04/2004 |
| 6730671 | Compounds useful as reversible inhibitors of cathespin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes, for making such novel compounds. | 05/04/2004 |
| 6696441 | Inhibition of p53-induced stress response The present invention provides compounds that act to suppress p53 activity in mammalian cells, and a method to effectively suppress p53 activity in the cells of a mammal subject to a stress or pathology that is ameliorated by such suppression.... | 02/24/2004 |
| 6686356 | Pyridoquinoxaline antivirals The present invention provides a compound of formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein R1 and R2 are as defined in the specification. The compounds are useful for the treatment of viral infections.... | 02/03/2004 |
| 6630475 | Adenosine A2a receptor antagonists Compounds having the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, cycloalkenyl, or heteroaryl; X is alkylene or --C(O)CH2 --; Y is --N(R2)CH2 CH... | 10/07/2003 |
| 6624159 | Heterocycle carboxamides as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 09/23/2003 |
| 6617329 | Aminoquinazolines and their use as medicaments Compounds of the formula ##STR1## having an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumoral diseases and diseases of the lungs and air-ways, and the preparation thereof... | 09/09/2003 |
| 6608053 | Fused heteroaryl derivatives The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which posse... | 08/19/2003 |
| 6608057 | Compounds useful as reversible inhibitors of cathepsin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds ##STR1##... | 08/19/2003 |
| 6586429 | Tricyclic fused xanthine compounds and their uses Novel tricyclic compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling. The compounds have the following formulas ##STR1## wher... | 07/01/2003 |
| 6570013 | Salts of zopolrestat This invention relates to [4-oxo-(5-trifluoromethyl-benzothiazol-2-ylmethyl)-3,4-dihydro-phthalazin- 1-yl]-acetic acid ethanolamine salt, pharmaceutical compositions thereof and methods of treating diabetic complications in mammals comprising administ... | 05/27/2003 |
| 6531475 | CRF receptor antagonists and methods relating thereto CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this in... | 03/11/2003 |
| 6518265 | 1H-imidazopyridine derivatives 1H-Imidazopyridine derivatives represented by the following general formula or salts thereof: ##STR1## wherein R1 represents hydrogen atom, hydroxyl group, an alkyl group, a cycloalkyl group, styryl group, or an aryl group; R2 repres... | 02/11/2003 |
| 6514982 | CRF receptor antagonists and methods relating thereto CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this in... | 02/04/2003 |
| 6495686 | Pyrimido [4,5,b]indolizine derivatives and aza analogues thereof; CRF1 specific ligands Disclosed are compounds of the formula: ##STR1## wherein Ar, R1, R2, R3, W, X, Y, and Z are substituents as defined herein, which compounds are highly selective partial agonists or antagonists at human CRF1 rece... | 12/17/2002 |
| 6482948 | Thienopyrimidine compounds and salts thereof and process for the preparation of the same Thieno[2,3-d]pyrimidine compounds of general formula (1) ##STR1## useful as drugs having a cGMP-specific phosphodiesterase inhibiting effect and the preparation thereof wherein Q is formula: (CH2)n --N(r1)--C(r2... | 11/19/2002 |
| 6462036 | Tricyclic pyrazole derivatives This invention relates to certain 3-aryl or 3-heteroaryl pyrazoles with 4,5(3,4)-bicyclic ring fusion which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to proc... | 10/08/2002 |
| 6451795 | 4-oxo-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-carboxamide derivatives, preparation and therapeutic use 4-Oxo-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-carboxamide derivatives having affinity for the peripheral benzodiazepine receptors are useful for the prevention or treatment of peripheral neuropathies and for the treatment of central neurogenerative disea... | 09/17/2002 |
| 6316438 | Fused pyridopyridazine inhibitors of cGMP phosphodiesterase Compounds of the formula ##STR1## are useful as inhibitors of cGMP PDE especially Type 5.... | 11/13/2001 |
