Class 544/114 - Diazine ring

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the additional hetero ring is six-membered
No. of patents: 179
Last issue date: 09/20/2011

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Number	Title	Issue Date
8022205	Pyrimidine derivatives as PI3K inhibitor and use thereof A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility. A compound, or pharmaceutically acceptable salt thereof, represe...	09/20/2011
7429660	ATM inhibitors A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 together form, along with the nitrogen atom to which they are attached, an op...	09/30/2008
7423148	Small molecule PI 3-kinase inhibitors and methods of their use Compounds having formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable ca...	09/09/2008
7371753	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions Disclosed are new dihydropteridinones of general formula (I) wherein the groups R1 to R5, Ra to Rc, W, Q1 and Q2 have the meanings given in the claims and sp...	05/13/2008
7365067	Indanol derivative The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein, R1, R2: optionally s...	04/29/2008
7332483	Amide derivatives The invention concerns amide derivatives of Formula (Ia) wherein X is —NHCO— or —CONH—; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R2 is a group su...	02/19/2008
7320977	Substituted 2-phenyl-3(2h)-pyridazinones The invention relates to substituted 2-Phenyl-3(2H)-Pyridazinones, to a method for the production thereof, and to their use as medicaments for the prophylaxis and/or treatment of diseases in humans and/or animals. ...	01/22/2008
7312215	Benzimidazole C-2 heterocycles as kinase inhibitors Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer. ...	12/25/2007
7309701	Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein A is A1 or A2; ...	12/18/2007
7307077	Heterocyclic compound and antitumor agent containing the same as effective ingredient The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: wherein X...	12/11/2007
7304050	Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a...	12/04/2007
7279475	Fluorinated di-aryl urea compounds Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus...	10/09/2007
7232820	Thiadiazole-amine compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R3, R5, R7, X, Y and U are as defined. Compounds of the Formula I have activity inhibiting produ...	06/19/2007
7217714	CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m...	05/15/2007
7211577	Water-soluble phenylpyridazine derivative and medicine containing the same A phenylpyridazine derivative represented by the formula (1): Wherein, R1, R2, R3, X, Y, Z and n have the same meaning as defined in the specification; or a salt thereof, or a medicine containing the compound. Th...	05/01/2007
7189718	Non-nucleoside reverse transcriptase inhibitors This invention relates to novel pyridazinone derivatives of formula I wherein R1–R4, R7, R8 and X1 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit o...	03/13/2007
7179806	Δ1-pyrrolines used as pesticides The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, m, and Q have the meanings given in the disclosure, to a plurality of processes fo...	02/20/2007
7153853	Heterocyclic compounds and antitumor drugs containing the same as the active ingredient The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen ...	12/26/2006
7141570	N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formula I described herein. ...	11/28/2006
7141588	N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ...	11/28/2006
7122546	Imidazol-1-ylmethyl pyridazine derivatives The invention provides imidazol-1-ylmethyl pyridazine derivatives of the formula: that bind to GABAA receptors. In the above formula, R1, R2 R3, R4, R5	10/17/2006
7115640	Heterocyclic modulators of nuclear receptors Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/or orphan nuclear receptors. I...	10/03/2006
7094900	N-Aryl-2-oxazolidinones and their derivatives The present invention provides antibacterial agents of formula I described herein. ...	08/22/2006
7071189	Heterocyclic compound and antitumor agent containing the same as active ingredient The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components:	07/04/2006
7064123	Compounds and compositions as cathepsin inhibitors The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. ...	06/20/2006
7049313	ATM inhibitors The application concerns a compound of formula I: wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3	05/23/2006
7037916	Pyrimidine derivatives as IL-8 receptor antagonists Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q...	05/02/2006
7012088	Indolone oxazolidinones and derivatives thereof The present invention provides antibacterial agents of formula I described herein and intermediates for their preparation. ...	03/14/2006
7012094	Substituted furans and furanones for the treatment of inflammation A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defin...	03/14/2006
6995261	4-pyridazinecarboxamides and esters as interleukin-1β converting enzyme inhibitors Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1 is a halogen, or an oxygen linked leaving group including an aromatic et...	02/07/2006
6936610	Heterocyclic derivatives The invention relates to heterocyclic derivatives of formula (I) A—B—X1—T1(R2)—L1—T2(R3)—X2—Q (I) or pharmaceutically-acceptable salts thereof, which ...	08/30/2005
6919329	N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ...	07/19/2005
6869954	Water-soluble phenylpyridazine compounds and compositions containing the same Compounds having the formula (1): wherein R1 represents an alkyl or alkenyl group, R2 and R3 each independently represent a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or al...	03/22/2005
6867206	6-carboxyphenyldihydropyridazinone derivatives and use thereof The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula wherein R1, R2, R3, A, D, G, and E are as defined in the specification and claims, a p...	03/15/2005
6861428	Water-soluble phenylpyridazine compounds and compositions containing the same Compounds having the formula (1): wherein R1 represents an alkyl or alkenyl group, R2 and R3 each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or a...	03/01/2005
6787650	Urea compounds, process for producing the same and use thereof A compound of the formula: [wherein R1 is a hydrocarbon group which may be substituted; R2 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substitu...	09/07/2004
6716838	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety o...	04/06/2004
6716851	Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defi...	04/06/2004
6710052	Pyrimidine compounds Pyrimidine derivatives of the formula (I) wherein: one of Q1 and Q2 or both of Q1 and Q2 is substituted on a ring carbon by one substituent of the formula (Ia) [provided that when present in Q1 the substituent o...	03/23/2004
6703371	Preparations for reducing oxygen consumption during physical efforts The invention relates to pharmaceutically active substances from the group comprising midazolam and compounds with a methyl-substituted nitrogen atom that is the ring atom of a nitrogenous heterocycle. These substances are used to reduce the oxygen consum...	03/09/2004

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Class 544/114 - Diazine ring