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| Number | Title | Issue Date |
| 7425561 | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The ar... | 09/16/2008 |
| 7371750 | Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or d... | 05/13/2008 |
| 7329658 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein. ... | 02/12/2008 |
| 7307077 | Heterocyclic compound and antitumor agent containing the same as effective ingredient The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: wherein X... | 12/11/2007 |
| 7304050 | Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a... | 12/04/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7160883 | Pyrrolo-triazine aniline compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R... | 01/09/2007 |
| 7157456 | Substituted oxazolidinones and their use in the field of blood coagulation The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxi... | 01/02/2007 |
| 7153853 | Heterocyclic compounds and antitumor drugs containing the same as the active ingredient The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen ... | 12/26/2006 |
| 7141588 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ... | 11/28/2006 |
| 7141570 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formula I described herein. ... | 11/28/2006 |
| 7129259 | Halogenated biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having at least one halogenated hydrocarbon moiety, a biaryl moiet... | 10/31/2006 |
| 7094900 | N-Aryl-2-oxazolidinones and their derivatives The present invention provides antibacterial agents of formula I described herein. ... | 08/22/2006 |
| 7071189 | Heterocyclic compound and antitumor agent containing the same as active ingredient The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: | 07/04/2006 |
| 7022808 | Polymers A polymer having a plurality of 5–6 membered unsaturated rings which may be the same or different, linked together by way of linker chains to form a backbone, at least some of said 5–6 membered unsaturated rings carrying a ligand. Polymers of this nature can act... | 04/04/2006 |
| 7022705 | Isoxazoline derivatives useful as antimicrobials Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an N-linked 5-membered, fully or partially u... | 04/04/2006 |
| 6998483 | Process for the preparation of sulphonamide-substituted imidazotriazinones The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) | 02/14/2006 |
| 6974812 | Benzamide inhibitors of the P2X7 Ereceptor The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R1-R3 are as defined herein. The compounds of the invention are useful in the treatment ... | 12/13/2005 |
| 6969726 | Biaryl heterocyclic compounds and methods of making and using the same The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety th... | 11/29/2005 |
| 6943158 | Diazinopyrimidines Compounds of formula I are p38 inhibitors: or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or alkyl; R2 alkyl, h... | 09/13/2005 |
| 6919329 | N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives The present invention provides antibacterial agents having the formulae I, II, and III described herein. ... | 07/19/2005 |
| 6908916 | C-5 modified indazolylpyrrolotriazines The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HE... | 06/21/2005 |
| 6894046 | IL-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X is O, S, NR5 | 05/17/2005 |
| 6890922 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizi... | 05/10/2005 |
| 6878708 | Imidazotriazinones and the use thereof Novel imidazotriazinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed. ... | 04/12/2005 |
| 6867207 | IL-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, p and q are 0, 1, 2, 3 or 4 and q is also 5... | 03/15/2005 |
| 6803365 | Imidazo[1,3,5]triazinones and the use thereof The invention relates to imidazo[1.3.5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases. ... | 10/12/2004 |
| 6777551 | Process for the preparation of sulphonamide-substituted imidazotriazinones The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) | 08/17/2004 |
| 6774127 | Pyrazole and pyrazoline substituted compounds Novel pyridyl and pyrimidinyl substituted pyrazole and pyrazoline compounds and compositions for use in therapy. ... | 08/10/2004 |
| 6743792 | 6-azauracil derivatives as IL-5 inhibitors The present invention is concerned with the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q r... | 06/01/2004 |
| 6683081 | Triazolotriazinones and the use thereof The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof. ##STR1##... | 01/27/2004 |
| 6680315 | Triazine compounds This invention relates to triazine compounds of formula (I): ##STR1## R1 is, aryl, ##STR2## or heteroaryl; each of R2, R4, and R5, independently, is Rc, halogen, nitro, nitroso, cyano, azide, isothion... | 01/20/2004 |
| 6670357 | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): ##STR1## or a pharmaceutically acceptable salt, prodrug, or so... | 12/30/2003 |
| 6642381 | Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B.... | 11/04/2003 |
| 6620812 | Sulfamoyl compounds and agricultural and horticultural fungicides A sulfamoyl compound of the general formulae (1): ##STR1## wherein R1 and R2 are each independently C1-4 alkyl, or R1 and R2 together are C4-6 alkylene or C4-6 alkyleneoxy, Y ... | 09/16/2003 |
| 6610677 | Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII: ##STR1## wherein Z1 is N or C--R9, Z2 is N or CH, and Z3 is N or C--Rx | 08/26/2003 |
| 6608004 | Substituted 2-aryl-1,2,4-triazine-3,5-di(thi)ones The invention relates to novel substituted 2-aryl-1,2,4-triazine-3,5-di(thi)ones of the general formula (I), ##STR1## in which Q1, Q2, R1, R2, R3, R4, R5 and R6 are ea... | 08/19/2003 |
| 6498158 | Il-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 4; --A--B-- represents --(CH2... | 12/24/2002 |
| 6476030 | Pyrazolo-triazine derivatives as ligands for GABA receptors Compounds according to Formula (I): ##STR1## or a salt or prodrug thereof, have good affinity as ligands for the alpha2 and/or alpha3 subunit of the human GABAA receptor and are useful for treatment of disorders of the central nervous system, i... | 11/05/2002 |
| 6469001 | IL-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 5; --A--B-- is --(CH2)r | 10/22/2002 |
