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| Number | Title | Issue Date |
| 7718798 | Indole compound The purpose of the present invention is to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like. The present invention provides a glucokinase activator containing ... | 05/18/2010 |
| 7560548 | Morpholin-acetamide derivatives for the treatment of inflammatory diseases There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes f... | 07/14/2009 |
| 7442716 | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to t... | 10/28/2008 |
| 7425572 | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma Novel dioxinoindazole compounds and dioxoloindazole compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions of one or more of... | 09/16/2008 |
| 7425555 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38. ... | 09/16/2008 |
| 7414054 | 3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 08/19/2008 |
| 7405210 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, ... | 07/29/2008 |
| 7402579 | Quinobenzoxazine analogs and compositions The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, ... | 07/22/2008 |
| 7402581 | Azetidine compounds The present invention relates to a compound of the general formula (I) wherein Het is an optionally substituted 4-, 5-, 6- or 7-membered heterocyclic ring having at least one nitrogen atom; R1 is hydrogen, hydroxy, C1-C4 alkyl, C3-C | 07/22/2008 |
| 7388095 | 5-substituted indole-2-carboxamide derivatives The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for t... | 06/17/2008 |
| 7388007 | Gamma-lactams as beta-secretase inhibitors There is provided a series of novel substituted gamma-lactams of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5 and R6 | 06/17/2008 |
| 7384939 | Process for preparation of pyridine derivatives of NK-1 receptor antagonist The present invention provides a process for preparing a pyridine compound of the formula: wherein R1, R2, R3 and a are those defined herein. ... | 06/10/2008 |
| 7384962 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 06/10/2008 |
| 7375119 | Amide type carboxamide derivative The present invention provides an amide-type carboxamide derivative of the formula [1]: wherein X is a group of the formula: —N═ or the formula: —CH═; R1 is a halogen atom, a lower alkyl group, and the li... | 05/20/2008 |
| 7371749 | Benzothiazole derivatives The present invention relates to compounds of formulae IA and IB wherein R1 and R2 are each independently lower alkyl or —(CH2)m—O-lower alkyl, or together with t... | 05/13/2008 |
| 7365066 | Pyrazolopyridine derivatives as pharmaceutical agents Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta. ... | 04/29/2008 |
| 7361654 | Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated disea... | 04/22/2008 |
| 7358247 | Mycophenolate mofetil impurity Provided is an impurity of mycophenolate mofetil, processes for its preparation and its use as a reference. ... | 04/15/2008 |
| 7351721 | Amino acid derivatives and pharmaceutical composition comprising, as active ingredients, them The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I) possess inhibitory activity of N-... | 04/01/2008 |
| 7332485 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 02/19/2008 |
| 7329765 | Benzothiophene compounds having antiinfective activity Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity. ... | 02/12/2008 |
| 7320992 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods fo... | 01/22/2008 |
| 7317010 | Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R1, R2, R4, R5, R6, R6a, R7, R8, A and ... | 01/08/2008 |
| 7312336 | Compounds with analgesic effect Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use ... | 12/25/2007 |
| 7304058 | Carbamic acid esters of benzothiazoles The present invention relates to a compound of formula I wherein R, X and n are defined hereinabove, and to a pharmaceutically acceptable salt thereof. The compound may be used for the treatment of diseases relat... | 12/04/2007 |
| 7285548 | Urea substituted benzothiazoles The present invention relates to compounds of formula I wherein R1 and R2 are described herein, and their pharmaceutically acceptable salts thereof for the... | 10/23/2007 |
| 7282499 | Sigma receptor inhibitors The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to some pyrazole derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy... | 10/16/2007 |
| 7279476 | Pyrazole-derived kinase inhibitors and uses thereof Described herein are compounds that are useful as protein kinase inhibitors having the formula: where B, R1, n, R3, Q, and R4 are described in the specification. The compounds are... | 10/09/2007 |
| 7279475 | Fluorinated di-aryl urea compounds Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus... | 10/09/2007 |
| 7273882 | Aminoacetamide acyl guanidines as β-secretase inhibitors There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R | 09/25/2007 |
| 7273865 | Thiazolopyridine The present invention relates to compounds of formula I wherein R1 and R2 are described hereinbelow. These compounds have high affinity to A2A receptors and good selectivity to A | 09/25/2007 |
| 7271181 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 09/18/2007 |
| 7262199 | Tyrosine kinase inhibitors The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogen... | 08/28/2007 |
| 7256188 | 3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam... | 08/14/2007 |
| 7253188 | Aminobenzamide derivative This invention relates to a novel compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is —S(O)p-A, ... | 08/07/2007 |
| 7247627 | Salts and polymorphs of a pyrrole-substituted indolinone compound The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The ... | 07/24/2007 |
| 7241760 | Heteroaryl-substituted imidazole derivatives The present invention relates to imidazole derivatives of the general formula wherein R1, R2, R3 and R4 are described hereinbelow. These compounds can be used in the tr... | 07/10/2007 |
| 7241779 | Fused pyrrolocarbazoles The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrol... | 07/10/2007 |
| 7217714 | CCR5 modulators Compounds of Formula 1 [Region α]−[Region β]−[Region γ]−[Region δ] (I) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m... | 05/15/2007 |
| 7214675 | Urea substituted imidazoquinoline ethers Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are us... | 05/08/2007 |
