Did You Know...
...that after Walter Hunt patented the safety pin in 1849, he sold the rights to it for $400?
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6903094 | Amide derivatives and nociceptin antagonists The present invention relates to a compound of the formula [1′] wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the lik... | 06/07/2005 |
| 6699858 | Halogen substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero, 1, 2, 3, 4, 5 or 6; X is CH2 or O; R1 | 03/02/2004 |
| 6613762 | Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by the general Formulae I-III: ##STR1## wherein R1 -R5 are defined in the specification.... | 09/02/2003 |
| 6511976 | Halogen substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero, 1, 2, 3, 4, 5 or 6; X is CH2 or O; R1 | 01/28/2003 |
| 6472388 | Aralkyl and aralkylidene heterocyclic lactams and imides The present invention relates to compounds of the formula ##STR1## wherein R1, R2, R3, X, Y and the dashed line are defined as in the specification, to intermediates for their preparation, to pharmaceutical compositions co... | 10/29/2002 |
| 6462041 | Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by the general Formulae I-III: ##STR1## wherein R1 -R5 are defined herein. The present invention also relates to the discovery that comp... | 10/08/2002 |
| 6403791 | Heterocyclic compounds and their therapeutic use A compound of the formula ##STR1## wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is C1-6 alkyl, cycloalkyl or NR4 R5 ; R3 is a pyrazole, imidazole or ... | 06/11/2002 |
| 6376489 | Cyclic AMP-specific phosphodiesterase inhibitors Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory disease and other diseases involving elevated levels of cytokines, as well as cen... | 04/23/2002 |
| 6342497 | 2"-deoxy hygromycin derivatives This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1 and R2 are as defined herein. The compounds of formula 1 are antibacterial and antiprotoz... | 01/29/2002 |
| 6096740 | Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions The present invention relates to pharmaceutical compositions for preventing or alleviating neurotoxicity. Said pharmaceutical compositions comprise as their active ingredient the stereospecific (+) enantiomers, having (3S,4S) configuration, of Ɗ6 | 08/01/2000 |
| 6030952 | Benzofuran-acrylic acid derivatives and their use as modulators of RXRs or RARs receptors The present invention provides novel heteroaryl compounds having the general formula (I): ##STR1## their pharmaceutical compositions to be used as human and veterinary medicine, particularly in the treatment of dermatological, rheumatic, respira... | 02/29/2000 |
| 5856520 | Substituted benzenedithiol metal complex A novel substituted benzenedithiol metal complex represented by the general formula (1) is provided. The substituted benzenedithiol metal complex is useful as a singlet oxygen quencher and as an optical data recording medium per se. ##STR1## whe... | 01/05/1999 |
| 5739318 | Labelling agents comprising boronic acid conjugates The present invention relates to labelling agents comprising non-proteinaceous boronic acid conjugates having absorption maxima at not less than 600 nm, said label being provided by e.g., an azine, triphenylmethane, cyanine or phthalocyanine dye. The labe... | 04/14/1998 |
| 5637703 | Derivatives of genistein The invention concerns chemical compounds, derivatives of genistein, which exhibit pronounced immunosuppressant and antitumor activity. In particular, the invention concerns compounds having general formula 1, where R1, R2, R3 | 06/10/1997 |
| 5475119 | Diallylammonium compounds, processes for their preparation and their use Ionic monomeric diallylammonium compounds having a targeted combination of diallylammonium cations with selected anions have particularly high and constant charge control properties and very good heat stabilities and dispersibilities. The compounds accord... | 12/12/1995 |
| 5373018 | Indole derivatives and pharmaceutical use thereof The invention relates to the compound of formula (I) ##STR1## wherein A represents an unsubstituted ethenyl group in the trans (E) configuration or a physiologically acceptable salt or metabilically labile ester thereof which are antagonists of excit... | 12/13/1994 |
| 5364859 | Imidazonaphthyridine derivatives Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R1 represents lower alkyl or substituted or unsubstituted aryl; and X-Y-Z represents ##STR2## wherein R2 represents hydrogen, lower... | 11/15/1994 |
| 5243053 | Methylene meldrum's acid precursors This invention provides new stabilized methylene Meldrum's acid precursors, a process for their preparation, and a process for using such compounds in the preparation of methylene Meldrum's acid.... | 09/07/1993 |
| 5126368 | Octenoic acid derivatives useful as thromboxane A2 inhibitors The invention describes the novel compound 6(Z)-8-([2,4,5-cis]-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl)oc tenoic acid of formula I and its pharmaceutically acceptable salts and pharmaceutical compositions, which are of value in treating certain... | 06/30/1992 |
| 5091169 | Dipyridoxyl phosphate NMRI contrast agent compositions N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monoph... | 02/25/1992 |
| 4992555 | Certain dipyridylphosphate chelatable compounds capable of forming metal ion chelates N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monoph... | 02/12/1991 |
| 4969950 | Triazole compounds and methods for regulating plant growth Triazole compounds of the formulae Ia and Ib ##STR1## where R1 is hydrogen or cyclopropyl, or is C1 -C4 -alkyl, C2 -C4 -alkenyl or C2 -C4 -alkynyl, each of which is unsubsti... | 11/13/1990 |
| 4933456 | Dipyridoxyl phosphate NMRI contrast agents N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,N'-diacetic acids, and N,N'-bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N'-diacetic acids, the corresponding monoph... | 06/12/1990 |
| 4902712 | Fluoroalkane derivatives The invention describes the novel compound 4(Z)-6-([2,4,5-cis]-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl)he xenoic acid of formula I and its pharmaceutically acceptacle salts and pharmaceutical compositions, which are of value in treating certain... | 02/20/1990 |
| 4892899 | Novel compositions based on tetrachloroisoindolinone pigments Composition of matter containing (a) a compound of the formula I ##STR1## in which A is one of the groups of the formulae ##STR2## in which B is --O--, --S--, --SO2 --, --N.dbd.N--, --CH2 --, --CH.dbd.CH--, ##STR3## ... | 01/09/1990 |
| 4866093 | M-4 and iso M-4 derivatives, their preparation and compositions containing them The dihydro-M-4 and dihydro-IsoM-4 hydroxy carboxylic acids of the formula (II): ##STR1## wherein one of R1 represents a hydrogen atom and the other represents a hydroxy group and wherein the structure shown as ##STR2## represent... | 09/12/1989 |
| 4855423 | Preparation of sulfatobetaines Sulfatobetaines are prepared by reacting an addition compound of sulfur trioxide and a tertiary amine with an alkylene carbonate.... | 08/08/1989 |
| 4831046 | Tetrazole derivatives of 1,3-dioxane and thromboxane A2 antigonizing use thereof The invention describes various novel tetrazole derivatives of the formula I in which R1 and R2 are independently hydrogen, trifluoromethyl or (1-6C)alkyl (but R1 and R2 is not greater than 6 carbon atoms), or R... | 05/16/1989 |
| 4829063 | Saccharine salts of substituted amines Fungicidally active novel saccharine salts of substituted amines of the formula ##STR1## in which A represents in each case optionally substituted 2-decahydronaphthyl or ଲ-naphthyl and R1 and R2 independently of one anothe... | 05/09/1989 |
| 4824844 | Saccharine salts of substituted amines, fungicidal compositions and use Fungicidally active saccharine salts of substituted amines of the formula ##STR1## in which A represents in each case optionally substituted cyclohexyl, cyclohexenyl or phenyl, R1 represents hydrogen or alkyl, R2 represents hydrogen ... | 04/25/1989 |
| 4803220 | Pharmaceutical agents The invention concerns the novel racemic and laevorotatory optically active forms of the thromboxane A2 antagonist 5(Z)-7-([ 2,4,5-cis]-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl)heptenoic acid of formula I, their salts, pharmaceutical... | 02/07/1989 |
| 4726835 | Herbicidal and plant growth regulating imidazoline derivatives Imidazoline derivatives represented by the general formula: ##STR1## (wherein all the symbols are as defined in appended claims), a process for preparation of said derivatives, and a herbicide or a plant growth regulator containing said derivative as... | 02/23/1988 |
| 4719297 | Acylphosphine compounds and their use as photoinitiators Acylphosphine compounds of the formula I ##STR1## where X is oxygen, sulfur or an electron pair, R1 is R4 or OR4, R2 is --OM, where M is a monovalent cation, R3 is aryl which is substituted at le... | 01/12/1988 |
| 4695587 | M-4 and IsoM-4 derivatives, their preparation and compositions containing them Tetrahydro-M-4 and tetrahydro-IsoM-4 hydroxy carboxylic acids of the formula (II): ##STR1## wherein one of R1 and R2 represents a hydrogen atom and the other represents a hydroxy group, and the salts and esters of said acids ... | 09/22/1987 |
| 4678496 | Cyclohexane derivatives having plant-growth regulating activities, and uses of these derivatives As new compound is provided a cyclohexane derivative of the formula ##STR1## wherein R represents a hydrogen atom or an alkyl group, an alkylthioalkyl group or an unsubstituted or substituted phenyl group; and R1 represents an alkyl group,... | 07/07/1987 |
| 4631283 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids The synthesis of substituted quinazolinones is described. The novel quinazolinones are renal vasodilators and thereby increase renal blood flow, and are useful as cardiovascular agents.... | 12/23/1986 |
| 4587296 | Organic thiosulphates and thiosulphonates useful as stabilizing agents for rubber vulcanisates Additives for rubber compositions, giving vulcanisates having improved retention of optimum physical properties, are compounds containing two or more groups of the formula --S--SO2 R linked by an organic bridging group, or polymers containing t... | 05/06/1986 |
| 4578383 | CL 1565 antibiotic compounds Novel phosphorus containing antibiotic compounds that are antitumor agents designated CL 1565-A, CL 1565-B, CL 1565-T and their salts, a process for the production and the method of using said compounds, and pharmaceutical compositions containing various ... | 03/25/1986 |
| 4555366 | Non-emissive, flame-retardant coating compositions The invention relates to room temperature-curable, non-emissive, flame-retardant coating compositions. The main resin for the coating compositions is a flame-retardant polymer selected from an air dryable flame-retardant polymer, a room-temperature curabl... | 11/26/1985 |
| 4486429 | Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them Compounds of the formula I: ##STR1## in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms and R1 and R2, which may be identical or different independently represent a hydrogen atom, an al... | 12/04/1984 |
