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| Number | Title | Issue Date |
| 7977476 | Methods of attaching biological compounds to solid supports using triazine Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety. ... | 07/12/2011 |
| 7728128 | Dibenzo[c,h][1,5]naphthyridines and their use as DNA probes The present invention concerns novel dibenzo[c,h][1,5]naphthyridine of formula (I) and their use as DNA probes, as well as the methods for marking DNA using the same. ... | 06/01/2010 |
| 7504499 | Methods of attaching biological compounds to solid supports using triazine Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety. ... | 03/17/2009 |
| 7407948 | Photosensitisers and their uses Phonoselenazinium compounds of Formula (1): and their use in photodynamic therapy (PDT), particularly as anti-infectives, as anti-cancer agents, and as sterilising agents both for direct use and in combination with a polyme... | 08/05/2008 |
| 7361755 | Transition-metal-catalyzed process for the conversion of alkenes to sterically hindered substituted n-alkoxyamines This invention pertains to a novel process for preparing sterically hindered N-substituted alkyloxyamines from alkenes by the transition-metal-catalyzed reaction of a intermediate alkylborane with a sterically hindered nitroxyl radical. ... | 04/22/2008 |
| 7345301 | Mixtures of matrix materials and organic semiconductors capable of emission, use of the same and electronic components containing said mixtures The present invention describes new types of material mixtures composed of at least two substances, one serving as a matrix material and the other being an emission material capable of emission, the latter comprising at least one element of atomic number greater tha... | 03/18/2008 |
| 7294738 | Phosphorous containing steroid mimics The present invention discloses novel steroid mimics wherein a tri- or tetravalent phosphorous atom is isosterically substituted at any one of the seventeen positions occupied by the carbon atom in the steroidal skeleton, and wherein each adjacent position to the ph... | 11/13/2007 |
| 7259258 | Methods of attaching biological compounds to solid supports using triazine Disclosed are methods of attaching biologically active compounds to a solid surface, comprising modifying the solid surface using triazine chloride and attaching the biologically active compound to the triazine moiety. ... | 08/21/2007 |
| 7250511 | Process for the preparation of cyclopenta[g]quinazoline derivatives Cyclopenta[g]quinazolines of formula (I), and esters and amides thereof may be made by reacting an ester or amide of formula (II); or a protected derivative thereof with a complex containing the (propargyl)Co2(CO)6+ion | 07/31/2007 |
| 7214794 | Ceramide analogs, process for their preparation and their use as antitumor agents The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors ... | 05/08/2007 |
| 7214800 | Compounds, compositions, and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 05/08/2007 |
| 7186834 | Substituted iminoazines The invention relates to novel substituted iminoazines of the general formula (I) in which R1, R2, R3, R4, Z1, Z2 and Z | 03/06/2007 |
| 7135047 | M-phenylenediamine derivatives as coupler components for the coloring of keratinic fibers Agents for coloring keratinic fibers are provided which contain specific m-phenylenediamine derivatives such as N-2-(morpholine-4-yl)ethyl-m-phenylenediamine, N-3-(morpholine-4-yl)propyl-m-phenylenediamine, and N-3-(imidazole-1-yl)-propyl-m-phenylenediamine. ... | 11/14/2006 |
| 7132295 | Isotopically coded affinity markers 3 This application relates to isotopically labeled affinity markers of the formula (II) for mass spectrometric analysis of proteins. In formula (II), the groups A, PRG, S, Z, L', Z', R, R',... | 11/07/2006 |
| 7022849 | Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7 Quinazoline and pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R1, R2, L, Y1, Y2, Y3 and Z are as described herein,... | 04/04/2006 |
| 7018840 | Fluorescent metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescent metal sensors for detecting metal ions, and methods of making and using the same. ... | 03/28/2006 |
| 6956109 | Ceramide analogs, process for their preparation and their use as antitumor agents The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors. ... | 10/18/2005 |
| 6936597 | Prodrugs of anticancer agents employing substituted aromatic acids Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing m... | 08/30/2005 |
| 6855503 | Heterocyclic FRETdye cassettes for labeling biological molecules and their use in DNA sequencing Exploitation of suitably functionalized heterocyclic molecules, in the design and synthesis of Fluorescence Resonance Energy Transfer (FRET) cassettes and their corresponding dideoxynucleotide terminators culminated into efficient reagents for DNA sequencing. Additi... | 02/15/2005 |
| 6846915 | Hydroxypyridonate and hydroxypyrimidinone chelating agents The present invention provides hydroxypyridinone and hydroxypyrimidone chelating agents. Also provides are Gd(III) complexes of these agents, which are useful as contrast enhancing agents for magnetic resonance imaging. The invention also provides methods of prepari... | 01/25/2005 |
| 6803447 | Preparation of supramolecular polymers by copolymerization of monomers containing quadruple hydrogen bonding units with regular monomers The invention relates to the synthesis of polymers containing self-complementary quadruple hydrogen groups by copolymerizing monomers containing a quadruple hydrogen bonding group with one or more monomers of choice. The resulting polymers show unique new characteri... | 10/12/2004 |
| 6797522 | Synthetic receptors The invention is directed to synthetic receptor(s) which comprises a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and may independently be straight chain, cyclic or branched. The template... | 09/28/2004 |
| 6699979 | Oligonucleotides having chiral phosphorus linkages Sequence-specific oligonucleotides are provided having substantially pure chiral Sp phosphorothioate, chiral Rp phosphorothioate, chiral Sp alkylphosphonate, chiral Rp alkylphosphonate, chiral Sp phosphoamidate, chiral Rp phosphoamidate, chiral Sp phospho... | 03/02/2004 |
| 6664398 | Derivatives of erythromycin, their preparation process and their use as medicaments A subject of the invention is the compounds of formula ##STR1## in which Y represents a hydrogen atom or a fluorine atom, n represents an integer comprised between 1 and 8, Z represents a hydrogen atom or the remainder of a carboxylic acid, optiona... | 12/16/2003 |
| 6547841 | Transition-metal-catalyzed process for the preparation of sterically hindered N-substituted alkoxy amines Sterically hindered N-substituted alkoxyamines are prepared by the transition-metal-catalyzed decomposition of diazonium salts in the presence of a sterically hindered nitroxyl radical. These compounds are useful as thermal and light stabilizers for a var... | 04/15/2003 |
| 6540820 | Heterocyclic compounds Compounds of the formula: ##STR1## where R1, R2, R3, R4, R5, R6, R7, R8, R'5, R'6, R'7, R'8 are hydroxy --NO2, -... | 04/01/2003 |
| 6525040 | Cyclic organoselenium compounds, their preparation and their uses The invention is directed to novel cyclic organoselenium compounds useful as antioxidants, pharmaceutical compositions containing them, and methods for their preparation.... | 02/25/2003 |
| 6514298 | Fuel additive and fuel composition Fuel additives comprise a compound having a group represented by the formula >C.dbd.=N-- (1). Also disclosed are fuel compositions containing such additives. The additives have a superior detergent effect to conventional gasoline detergents and an excell... | 02/04/2003 |
| 6486154 | (Hetero) aryl-sulfonamide derivatives, their preparation and their use as factor XA inhibitors A compound of formula (I), ##STR1## or a pharmaceutically-acceptable salt thereof, wherein A is an optionally substituted 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 ring heteroatoms; B is optionally substituted phenylene or a 6-membere... | 11/26/2002 |
| 6448241 | Thiazolobenzoheterocycles, their preparation and medicaments containing them Compounds of formula (I): ##STR1## their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them are discussed.... | 09/10/2002 |
| 6414104 | Arylamine-substituted poly (arylene vinylenes) and associated methods of preparation and use The invention provides novel conjugated polymers comprised of arylamine-substituted poly(arylene vinylenes). The polymers have the general structure (I) ##STR1## wherein: Ar is arylene, heteroarylene, substituted arylene or substituted heteroarylene ... | 07/02/2002 |
| 6410684 | Serine protease inhibitors Serine protease inhibitors, prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. The serine protease inhibitors exhibit anticoagulant activity and are useful for treating or preventing thrombin related diseases.... | 06/25/2002 |
| 6407083 | Uses of novel organoselenium compounds with pro-oxidant activity Compounds represented by the following formula I: ##STR1## in which: R1 to R5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR6 R7) | 06/18/2002 |
| 6375930 | Membrane incorporation of texaphyrins Compositions having a texaphyrin-lipophilic molecule conjugate loaded into a biological vesicle and methods for imaging, diagnosis and treatment using the loaded vesicle are provided. For example, liposomes or red blood cells loaded with a paramagnetic te... | 04/23/2002 |
| 6372881 | Monomers for preparing arylamine-substituted poly(arylene-vinylenes) The invention provides novel conjugated polymers comprised of arylamine-substituted poly(arylene vinylenes). The polymers have the general structure (I) ##STR1## wherein: Ar is arylene, heteroarylene, substituted arylene or substituted heteroarylene ... | 04/16/2002 |
| 6365736 | Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.... | 04/02/2002 |
| 6313301 | Thienopyridine derivatives, their intermediates and production thereof The present invention provides an intermediate for producing a thienopyridine derivative useful as a GnRH antagonist as well as an efficient and safe method for producing the same in an industrial scale at a high yield.... | 11/06/2001 |
| 6303609 | Isoxazoline fibrinogen receptor antagonists This invention relates to novel isoxazolines and isoxazoles of formula (I): ##STR1## or a pharmaceutically acceptable salt or prodrug form thereof. The invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein II... | 10/16/2001 |
| 6218359 | Screening method using the RZR receptor family The current invention concerns the use of a receptor from the RZR/ROR receptor family or of a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor, melatonin-like and/or melatonin-antagonistic activity and th... | 04/17/2001 |
| 6214996 | Naphthalene derivates, process for the preparation thereof, and intermediates therefor Naphthalene derivatives of the formula [I]: ##STR1## wherein R1 and R2 are the same or different and are each H, protected or unprotected OH, one of R3 and R4 is protected or unprotected hydroxymethyl, and the o... | 04/10/2001 |
