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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 5837698 | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.... | 11/17/1998 |
| 5670676 | Process for preparation of 9 -chloro-11ଲ formyloxypregna-3.20-diones Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected f... | 09/23/1997 |
| 5602248 | Process for preparation of 9-chloro-11ଲ-formyloxypregna-3,20-diones Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected f... | 02/11/1997 |
| 5053404 | Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen, b... | 10/01/1991 |
| 4695625 | Process for the preparation of 16,17 acetals of pregnane derivatives A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described. In the instance of the preparation of 16,17-butylidenedioxy-11ଲ,21-dihydroxypregna-1,4-diene- 3,20-dione, a c... | 09/22/1987 |
| 4613463 | Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid This invention discloses an improved process for the production of corticoids from 17-hydroxy steroids utilizing peroxymonosulfate.... | 09/23/1986 |
| 4404141 | Ɗ9(11) - And Ɗ16 -21-chloro-20-keto steroids of the pregnane and D-homopregnane series, their preparation and use as intermediates for the synthesis of highly effective corticoids Ɗ16 - and Ɗ17 -21-chloro-20-keto steroids of the formula ##STR1## wherein n is 1 or 2, C1 C2 and C9 C11 represent a CC-single or CC-double bond, R1 is H or OH, R2 | 09/13/1983 |
| 4390533 | Steroids and process for preparing the same The present invention relates to 2-chloro-6ଲ-fluoro-pregna-1,4-diene-3,20-diones having good anti-inflammatory activity, to processes for their preparation and pharmaceutical compositions thereof.... | 06/28/1983 |
| 4383992 | Water-soluble steroid compounds Beta-cyclodextrin forms a water-soluble complex or inclusion compound with steroid compounds having a molecular structure smaller than the interior cavity in the doughnut-shaped molecular structure of beta-cyclodextrin. The resulting inclusion compounds c... | 05/17/1983 |
| 4340538 | Process for producing 6-fluoro-Ɗ1,4 -3-keto steroids Two processes are disclosed (one-pot and two-pot) for the transformation of a 6ଲ-fluoro-Ɗ1,4 -3-keto steroid (IV) to a 6-fluoro-Ɗ1,4 -3-keto steroid (VI). These processes permit the introduction of a fluorine atom at t... | 07/20/1982 |
| 4322349 | Process for preparing 6-methylene steroids A process for preparing a 6-methylene-Ɗ4 -3-keto steroid of the formula ##STR1## wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group is that of a carboxylic acid, and R' is the C... | 03/30/1982 |
| 4275061 | Steroids and process for preparing the same The present invention relates to 2-chloro-6ଲ-fluoropregna-1,4-diene-3,20-diones having good anti-inflammatory activity, to processes for their preparation and pharmaceutical compositions thereof.... | 06/23/1981 |
| 4273770 | 4-Halo steroids Certain pregn-4-ene-3,20-diones or pregn-1,4-diene-3,20-diones 4-substituted with a fluoro or chloro are useful as topical anti-inflammatory steroids. These compounds are substituted at 9 with hydrogen, fluoro, chloro or bromo; at 6 with hyd... | 06/16/1981 |
| 4272446 | Steroids and process for preparing the same Novel steroids are described together with processes of making them and pharmaceutical compositions containing them. The steroids have pharmaceutical activity, especially antiinflammatory activity. They are all 2-Bromo-6ଲ-fluoro-pregna-1,4-diene-3,2... | 06/09/1981 |
| 4267173 | Use of 6ଲ-fluoro-7-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor Described is the use of 6ଲ-fluoro-7-halogeno-1,4-pregnadiene-17,21-diol-3,20-di ones and their esters as topical anti-inflammatory agents, and pharmaceutical formulations thereof useful therefor. Preferred compounds are 6ଲ,9&... | 05/12/1981 |
| 4230621 | Steroid derivatives and their use in radioimmunoassays Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said de... | 10/28/1980 |
| 4226862 | Steroids and process for preparing the same Novel steroids are described together with processes of making them and pharmaceutical compositions containing them. The steroids have pharmaceutical activity, especially anti-inflammatory activity. They are all 2-Bromo-6ଲ-fluoro-pregna-1,4-diene-3,... | 10/07/1980 |
| 4207235 | Selective epoxidation of steroidal bromohydrins Vicinal steroidal epoxides are prepared by reacting the corresponding vicinal steroidal bromohydrin with a heterocyclic base such as 1,5-diazabicyclo[4.3.0]non-5-ene or 1,5-diazabicyclo[5.4.0]-undec-5-ene.... | 06/10/1980 |
| 4201778 | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates Novel 6-acyloxy-3,20-dioxo-1,4,6-pregnatrienes and 6-acyloxy-3,20-dioxo-4,6-pregnadienes, useful anti-inflammatory agents, are prepared by reaction of the corresponding 3,6,20-trioxo-1,4-pregnadiene or 3,6,20-trioxo-4-pregnene with an acyl halide or ... | 05/06/1980 |
| 4198336 | Chemical process for preparing androsta-4-ene 17-carboxylic acids This invention is a process for preparing 3-keto-androst-4-ene 17-carboxylic acids, androsta-1,4-diene 17-carboxylic acids and their 17-esters by reacting a corresponding 21-hydroxypregn-4-ene-3,20-dione, 21-hydroxypregna-1,4-diene-3,... | 04/15/1980 |
| 4198403 | 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 4-position with a fluoro, chloro or bromo and optionally substituted at the six position with fluoro or chloro are useful as anti-inflammatory ste... | 04/15/1980 |
| 4181669 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.... | 01/01/1980 |
| 4181720 | Corticosteroid antiinflammatory agents 22-Optionally substituted steroids of the corticoid series are prepared from the corresponding 21-methylene steroids through the 20,21-dione steroid intermediates. These compounds have utility as anti-inflammatory agents.... | 01/01/1980 |
| 4180504 | Method for the preparation of esters This invention relates to an improved ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.... | 12/25/1979 |
| 4172075 | Fluoro-steroids and processes for their manufacture 11,12-Unsaturated 9-fluorosteroids comprising a new class of steroid compounds are obtained by a novel process, wherein a corresponding 9-fluoro-11ଲ-hydroxysteroid is dehydrated with a reagent of the formula F3 SX in which X... | 10/23/1979 |
| 4124707 | 7-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor Novel 3,20-dioxo-7-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7-bromo- and 7-chloro- derivatives, particularly 7-bromo- and 7-chloro-1,4-pregnadienes-11ଲ,17�... | 11/07/1978 |
| 4086254 | Photocleavable steroids This invention relates to novel compounds of the formula: ##STR1## wherein X is H, methoxy, bromine or chloro; R1 is hydrogen or hydroxy, acyloxy wherein acyl is 2 to 8 carbon atoms, R2 is hydrogen, hydroxy, methyl, fluoro or ch... | 04/25/1978 |
| 4065452 | 21,21-Dihalo steroids Novel, topically-active anti-inflammatory steroids are represented by the formula ##STR1## wherein X is fluoro, chloro or hydrogen; X1 is fluoro, chloro, bromo, or hydrogen; X2 is hydroxy or may be chloro when X1 is c... | 12/27/1977 |
| 4064240 | 21-Cyclic acetals of steroidal 21-aldehydes and methods of preparation 21-Cyclic acetals of steroids of the corticoid series are prepared from the corresponding 21-hydroxy steroids. The products have utility as anti-inflammatory agents.... | 12/20/1977 |
| 4049804 | Novel pregnanoic acid derivatives Pregnanoic acid derivatives of general formula ##STR1## wherein is a single bond or a double bond; X is hydrogen, fluorine or methyl; Y is hydrogen, fluorine or chlorine; Z is ଲ-hydroxymethylene, ଲ-acyloxymethylene, ଲ-fluoromethyl... | 09/20/1977 |
| 4031075 | Alkylated pregnanes and process for obtaining same The invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## WHEREIN X = H or halogen; Y = h2, h(oh), h(oacyl), O or H(halogen); R1 = an alkyl group having 1-4 C-atoms; R2 = r | 06/21/1977 |
| 4011315 | 21-Acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation 21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES ARE PREPARED FROM THE CORRESPONDING 21-HYDROXY STEROIDS AND HAVE UTILITY AS ANTI-INFLAMMATORY AGENTS.... | 03/08/1977 |
| 3996358 | 21-Esters of steroidal-21-aldehyde hydrates and 21-aldehyde hemiacetals and methods of preparation 21-Esters of 21-aldehyde hydrates and 21-aldehyde hemiacetals of steroids of the corticoid series are prepared from the corresponding 21-hydroxy steroids and have utility as antiinflammatory agents.... | 12/07/1976 |
| 3984544 | Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor Novel retinoic acid esters of anti-inflammatory steroids of the pregnane series are described and their use in the treatment and control of acne vulgaris via the topical or intralesional route. A preferred mode of the invention comprises treating acne by ... | 10/05/1976 |
| 3975378 | 20-Cyano-20,21-epoxy steroids Novel compounds useful as anti-inflammatories are represented by the formula ##SPC1## Wherein Z is a single or double bond; X and X1 are independently H, F or Cl; and X2 is OH or when X1 is Cl X2 may also be Cl.... | 08/17/1976 |
| 3974143 | (16)-16,17-ALKYLIDENEBIS(OXY)-3-ARYLPREGNA-2,4-TRIEN-20-ONES Preparation of (16)-16,17-alkylidenebis(oxy)-3-arylpregna-2,4,6-trien-20-ones and their progestational and glucocorticoid antiinflammatory utility are disclosed.... | 08/10/1976 |
| 3971773 | Steroidal 9,11-dihalo-[16,17-b]1,4-dioxanes A series of novel steroidal 9,11ଲ-dihalo-[16,17-b]-1,4-dioxanes is disclosed herein. These compounds are useful as anti-inflammatory agents.... | 07/27/1976 |
| 3971772 | Steroidal[16,17-b]1,4-dioxanes and Steroidal[16,17-b]1,4-dioxins A series of novel steroidal [[16,17-b]1,4-dioxanes and steroidal [ 16,17-b]1,4-dioxins having useful anti-inflammatory properties is disclosed herein.... | 07/27/1976 |
