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A method of swing on a swing is disclosed, in which a user positioned on a standard swing suspended by two chains from a substantially horizontal tree branch induces side to side motion by pulling alternately on one chain and then the other.
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| Number | Title | Issue Date |
| 8158780 | Processes for the preparation of ciclesonide and its crystal modification Improved processes for the synthesis of ciclesonide, chemically termed as [11β,16α(R)]-16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione and its crystal modification. ... | 04/17/2012 |
| 8119793 | Process for preparing budesonide A process is described for preparing budesonide which comprises the steps of: a) preparing an aqueous hydrochloric acid solution; b) reacting 16α-hydroxyprednisolone and butyraldehyde within the solution prepared in step a), in an inert atmosphere; c) quenching the... | 02/21/2012 |
| 7468433 | Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation The invention relates to a process for the preparation of 16,17-[(cyclohexylmethylene)bis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione[11β,16α(R)] and similar compounds, by reaction of an appropriate 16,17-ketal with cyclohexanealdehyde. ... | 12/23/2008 |
| 7205288 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 04/17/2007 |
| 6787533 | Process for R-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregna,4-dien-11.beta., 16.alpha., 17.alpha.-triol-3,20-dione derivatives R-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregna-1,4-dien-11beta,16alpha,17alpha-triol-3,20-dione derivatives is effected by fractional crystallization. ... | 09/07/2004 |
| 6392036 | Dry heat sterilization of a glucocorticosteroid The invention provides a process for the sterilization of a powdered form of a glucocorticosteroid, sterile glucocorticosteroids, sterile formulations containing glucocorticosteroids and use thereof in the treatment of an allergic and/or inflammatory cond... | 05/21/2002 |
| 6369218 | Isomerisation of 6ଲ-fluorosteroids into the corresponding 6-fluoro derivatives Described herein is the isomerisation process of 6ଲ-fluorosteroids into the corresponding pharmacologically active 6-fluoro derivatives, comprising the reaction of 6ଲ-fluorosteroids, or 6/6ଲ isomeric mixtures, with an organ... | 04/09/2002 |
| 6239120 | Method and means for treating glomerulonephritis The invention provides the use of a glucocorticoid having a first pass metabolism in the liver of at least 90% as active substance, for the manufacturing of a medicament for oral or rectal administration in the treatment of glomerulonephritis by releasing... | 05/29/2001 |
| 6197762 | Nitrosated and nitrosylated steroids compositions, and methods for treating respiratory disorders Disclosed are (i) compounds of a steroid, a ଲ-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production... | 03/06/2001 |
| 6169178 | Process for the preparation of 16,17 acetals of pregnane derivatives with control of the epimeric distribution at the C-22 position Described herein is a process for the preparation of an acetal of formula (I) in which R1 is an alkyl, R2 is H or an acyl, X is ଲ-OH and Y is H, comprising the acetalization with control of the epimeric distribution at the C-22... | 01/02/2001 |
| 5837698 | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.... | 11/17/1998 |
| 5824669 | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders Disclosed are (i) compounds of a steroid, a ଲ-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production... | 10/20/1998 |
| 5792758 | Steroid nitrite ester derivatives useful as anti-inflammatory drugs The present invention discloses novel steroid nitrite ester derivatives, and to their use treating inflammatory diseases.... | 08/11/1998 |
| 5733901 | Prednisolone derivatives Epimers of the compound having the formula (I) are disclosed, both in their pure form and mixed in any desire mix ratio. ##STR1##... | 03/31/1998 |
| 5670676 | Process for preparation of 9 -chloro-11ଲ formyloxypregna-3.20-diones Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected f... | 09/23/1997 |
| 5616573 | Glucocorticoids Glucocorticoids of general formula I R--Val--O--GC (II), are described, in which O-GC is the radical of a 21-hydroxycorticoid that has an antiinflammatory action, Val represents a valine radical in the 21-position of the corticoid and R means a hydrogen atom or a h... | 04/01/1997 |
| 5614514 | Steroid esters Compounds of the general formula (I), ##STR1## in which formula the 1,2-position is saturated or is a double bond, R1 is hydrogen or a straight or branched hydrocarbon chain, R2 is hydrogen or a straight or branched hydrocarbon ... | 03/25/1997 |
| 5602248 | Process for preparation of 9-chloro-11ଲ-formyloxypregna-3,20-diones Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected f... | 02/11/1997 |
| 5556964 | Process for the manufacture of budesonide The present invention relates to a novel process for the manufacture of (22 R,S)-16, 17-butylidenedioxy-11ଲ, 21-dihydroxypregna-1,4-diene-3,20 dione (I) by reacting 11ଲ, 16, 17 21-tetrahydroxypregna-1,4-diene (II) w... | 09/17/1996 |
| 5482934 | Pregna-1,4-diene3,20-dione-16-17-acetal-21 esters, process for their preparation, composition, and methods for the treatment of inflammatory conditions The present invention relates to compounds of the formula: ##STR1## in which X1 and X2 correspond to H or F without distinction; R1 represents the following radicals: ##STR2## and R2 represents the rad... | 01/09/1996 |
| 5434258 | δ1,4 -pregnadiene-3,20-diones A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsul... | 07/18/1995 |
| 5310896 | Process for preparing Ɗ1,4 -pregnadiene-3,20-diones A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsul... | 05/10/1994 |
| 5200518 | Anti-inflammatory carboxycyclic acetal pregnane derivatives Compounds of the formula: ##STR1## wherein X is H, F, Cl, or CH3 and Y is ##STR2## wherein R1 is H, alkyl of 1-5 carbon atoms, phenyl, or benzyl; R2 is COOR6, R5 COOR6, or R5 | 04/06/1993 |
| 5053404 | Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen, b... | 10/01/1991 |
| 4950659 | 16,17-acetalsubstituted androstane-17ଲ-carboxylic acid esters prossessing high binding affinity to the glucocorticosteroid receptor The invention refers to compounds having anti-inflamatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula the 1,2-position is saturated or is a double bond X1 is selected from hydrogen... | 08/21/1990 |
| 4933168 | Stable, crystalline flunisolide A unique crystalline polymorphic form of flunisolide is disclosed which is stable in aerosols such as Freon.RTM. mixtures and is valuable in the treatment of respiratory diseases, particularly bronchial asthma and allergic rhinitis.... | 06/12/1990 |
| 4925933 | Method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives characterized in reaction of a corresponding 16,17-acetonide with an aldehyde or ketone in (a) hydrocarbon solvent wherein the solubility of the ... | 05/15/1990 |
| 4835145 | 16,17 acetals of pregnane derivatives and pharmaceutical compositions containing them A compound exhibiting anti-inflammatory properties having the formula ##STR1## in which X is H, Hal or CH3 COO--; R1 is CH3 (CH2)2 CH--; and R2 and R3 are separately H or Hal; ... | 05/30/1989 |
| 4695625 | Process for the preparation of 16,17 acetals of pregnane derivatives A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described. In the instance of the preparation of 16,17-butylidenedioxy-11ଲ,21-dihydroxypregna-1,4-diene- 3,20-dione, a c... | 09/22/1987 |
| 4693999 | Liposomes containing steroid esters Pharmaceutical composition for administration primarily to the respiratory tract when treating and controlling anti-inflammatory conditions comprising liposomes in combination with a compound of the formula ##STR1## and R1 is a saturated o... | 09/15/1987 |
| 4613463 | Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid This invention discloses an improved process for the production of corticoids from 17-hydroxy steroids utilizing peroxymonosulfate.... | 09/23/1986 |
| 4456601 | 3-Chloro-pregnane derivatives and a process for the preparation thereof New Ɗ1,3,5 -3-chloro-pregnane derivatives of the general formula (I), ##STR1## wherein X is hydrogen atom, acetyl group or a chloroacetyl group, and Y and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of ... | 06/26/1984 |
| 4432976 | Cyclocarbonate esters of 16,17, dihydroxy anti-inflammatory steroids Corticoids of Formula I ##STR1## wherein is a single bond or a double bond, X is hydrogen, fluorine, or chlorine, Y represents two hydrogen atoms or an oxygen atom, and Z is hydrogen or acyloxy of 2-6 carbon atoms, are pharmacologically active compounds... | 02/21/1984 |
| 4404200 | 4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents at the carbon atom in ... | 09/13/1983 |
| 4404141 | Ɗ9(11) - And Ɗ16 -21-chloro-20-keto steroids of the pregnane and D-homopregnane series, their preparation and use as intermediates for the synthesis of highly effective corticoids Ɗ16 - and Ɗ17 -21-chloro-20-keto steroids of the formula ##STR1## wherein n is 1 or 2, C1 C2 and C9 C11 represent a CC-single or CC-double bond, R1 is H or OH, R2 | 09/13/1983 |
| 4383992 | Water-soluble steroid compounds Beta-cyclodextrin forms a water-soluble complex or inclusion compound with steroid compounds having a molecular structure smaller than the interior cavity in the doughnut-shaped molecular structure of beta-cyclodextrin. The resulting inclusion compounds c... | 05/17/1983 |
| 4376767 | Pyridylmethyl esters of selected bio-affecting carboxylic acids Novel pharmaceutically useful derivatives of selected known bio-affecting carboxylic acids are disclosed, said derivatives having the structural formula ##STR1## wherein R1 and R2, which can be the same or different, are each ... | 03/15/1983 |
| 4322349 | Process for preparing 6-methylene steroids A process for preparing a 6-methylene-Ɗ4 -3-keto steroid of the formula ##STR1## wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group is that of a carboxylic acid, and R' is the C... | 03/30/1982 |
| 4221787 | Esteramide prodrugs of anti-inflammatory corticosteroids Transient, C-21 and/or C-17 esteramide prodrugs of the anti-inflammatory corticosteroids, prepared by esterification of hydroxy steroids, are disclosed.... | 09/09/1980 |
| 4198336 | Chemical process for preparing androsta-4-ene 17-carboxylic acids This invention is a process for preparing 3-keto-androst-4-ene 17-carboxylic acids, androsta-1,4-diene 17-carboxylic acids and their 17-esters by reacting a corresponding 21-hydroxypregn-4-ene-3,20-dione, 21-hydroxypregna-1,4-diene-3,... | 04/15/1980 |
