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| Number | Title | Issue Date |
| 7368443 | 2,6-disubstituted piperidines and piperazine compounds The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: which are used to treat diseases of the central nervous system, drug abuse, and withdrawal there... | 05/06/2008 |
| 7226917 | Derivatives of N-[phenyl(pyrrolidine-2-yl)methyl]benzamide and N-[(azepan-2-yl)phenylmethyl]benzamide, preparation, and use in treatment of schizophrenia Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic ... | 06/05/2007 |
| 7208632 | Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine The invention relates to the field of separation by distillation of 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) from a mixture comprising ACN, HMD, tetrahydroazepine (THA), adiponitrile (ADN) and low boilers (LB). Also disclosed is a method for producin... | 04/24/2007 |
| 7189792 | Catalyst for synthesizing high trans polymers The process and catalyst of this invention can be utilized to synthesize homo and copolymers of conjugated diene monomers and vinyl aromatic monomers having high trans contents of greater than 60% with low melting points. These homo and copolymers of conjugated dien... | 03/13/2007 |
| 7166747 | Synthesis of soluble functionalized lithium initiators This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desira... | 01/23/2007 |
| 7147757 | Method for separating an azepine derivative out of a mixture containing an amine an azepine derivative The invention relates to a method for separating by distillation a portion or the entirety of an azeptine derivative (III), which is selected from the group consisting of aminohexylidene imine, tetrahydroazepine, hexylhexahydroazepine and of aminohexylhexahydroazepi... | 12/12/2006 |
| 7022845 | Monomethylation of nitrogeneous heterocycles A process for the monomethylation of nitrogenous heterocycles having at least one nitrogen atom bonded to a hydrogen atom by reacting the nitrogenous heterocycle with dimethyl carbonate at a temperature of between 100° and 200° C. and a pressure of between 0.93×1... | 04/04/2006 |
| 6943177 | Cis-2,6-disubstituted piperidines for the treatment of psychostimulant abuse and withdrawal, eating disorders, and central nervous system diseases and pathologies Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula: are used to treat diseases of the central nervous system, drug abuse and withdrawal therefrom as well as to treating eating diso... | 09/13/2005 |
| 6908914 | Antipsychotic cyclic N-aralkylamines The invention relates to benzene derivatives, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of psychotic disorders. ... | 06/21/2005 |
| 6887865 | N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the... | 05/03/2005 |
| 6887994 | C-nitroso compounds and use thereof A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon a... | 05/03/2005 |
| 6803462 | Process for synthesizing functionalized styrene monomer This invention discloses a rubbery polymer which is comprised of repeat units that are derived from (1) at least one conjugated diolefin monomer, and (2) at least one functionalized monomer having of the structural formula: ... | 10/12/2004 |
| 6753447 | Functionalized monomers for synthesis of rubbery polymers This invention discloses a process for synthesizing an amine functionalized monomer that comprises (1) reacting a secondary amine with a 2,3-dihalopropene to produce a vinyl halide containing secondary amine having a structural formula selected from the group consis... | 06/22/2004 |
| 6670471 | Process for synthesizing functionalized styrene monomer This invention discloses a rubbery polymer which is comprised of repeat units that are derived from (1) at least one conjugated diolefin monomer, and (2) at least one functionalized monomer having of the structural formula: ##STR1## wherein R represe... | 12/30/2003 |
| 6528647 | Process for the synthesis of an aliphatic cyclic amine Disclosed is a process for selectively producing aliphatic cyclic amines which comprises reacting a dihydric alcohol characterized by four to six carbons, preferably 1,5-pentane diol, with excess ammonia in presence of ZSM-5 catalyst modified with group o... | 03/04/2003 |
| 6495543 | Polycyclic azaindole compounds The invention relates to compounds of formula (I): ##STR1## wherein: G1 represents an alkylene chain as defined in the description, A represents ##STR2## R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or together f... | 12/17/2002 |
| 6482944 | Processes for preparing tertiary aminoalkylorganometallic compounds Processes for the preparation of haloalkylamines and tertiary aminoalkylorganometallic compounds are disclosed. The haloalkylamines can be prepared by direct reaction of an amine with an , ω-dihaloalkane or an , ω-dihaloalkene. Tertiary ... | 11/19/2002 |
| 6451817 | Alpha-substituted-1-benzyl-napthyls This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are -substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medica... | 09/17/2002 |
| 6444662 | Stable hyperforin salts, method for producing same and their use in the treatment of alzheimer's disease Described are salts of hyperforin and adhyperforin of formula I [A- ]m [B]p+ (I) wherein m is an integer from 1 to 3, p is equal to m and gives the total number of positive charges of the residue [B], [A- ] is an anion o... | 09/03/2002 |
| 6417353 | Preparing amines Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing coppe... | 07/09/2002 |
| 6417365 | Method for recovering medicaments from preparations, and from the precursors or wastes thereof In a process for recovering medicinal substances or active substances from preparations, their initial products or waste, a flat-shaped starting material in the form of a film with adhesive and an active substance-containing material is provided with one ... | 07/09/2002 |
| 6391892 | Naphthyl pharmaceutical compounds The present invention provides a compound of formula I ##STR1## wherein R1 is H, OH, halo, OCO(C1 -C6 alkyl), OCO(aryl), OSO2 (C4 -C6 alkyl), OCOO(C1 -C6 alkyl), OCOO(aryl)... | 05/21/2002 |
| 6384053 | -substituted-1-benzyl-napthyls This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are -substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indication... | 05/07/2002 |
| 6362333 | Method for simultaneously producing a cyclic lactam and a cyclic amine A cyclic lactam and a cyclic amine are coproduced by coreacting an aliphatic alpha, omega-diamine and an aliphatic alpha, omega-aminonitrile with water in the gas phase in the presence of a heterogeneous catalyst.... | 03/26/2002 |
| 6362332 | Coproduction of a cyclic lactam and a cyclic amine A cyclic lactam and a cyclic amine are coproduced by reacting an aliphatic alpha, omega-diamine with water in the gas phase in the presence of a heterogeneous catalyst.... | 03/26/2002 |
| 6348630 | Method for purifying hexamethylenediamine in mixtures of hexamethylenediamine and an unsaturated cyclic imine The level of an unsaturated cyclic imine (I) of the formula (I) ##STR1## where R1 is alkenyl having 3, 4, 5, 6, 7, 8, 9, 10, 11 carbon atoms belonging to the ring system, in a mixture comprising hexamethylenediamine and an imine (I) is reduced ... | 02/19/2002 |
| 6300497 | Method for separating an azepine derivative from a mixture containing an amine and an azepine derivative A process for distillative removal of part or all of an azepine derivative (III) selected from the group consisting of aminohexylideneimine, tetrahydroazepine, hexylhexahydroazepine and aminohexylhexahydroazepine from a mixture (II) comprising an azepine ... | 10/09/2001 |
| 6165230 | 1,4-diazacycloheptane derivatives and their use in hair oxidation dyes A 1,4-diazacycloheptane derivative and an oxidative hair colorant containing the derivative as a primary intermediate is presented. The 1,4-diazacycloheptane derivative is of the formula: ##STR1## where R1, R2, R3 and... | 12/26/2000 |
| 6140321 | Polymorphs of donepezil hydrochloride and process for production Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produce... | 10/31/2000 |
| 5998441 | Benzothiophene compounds, intermediates, compositions, and methods A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I ##STR1## wherein R1a is --H or --OR7a in which R7a i... | 12/07/1999 |
| 5985864 | Polymorphs of donepezil hydrochloride and process for production Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produce... | 11/16/1999 |
| 5912343 | Tertiary amines containing side-chain organolithium structures and method for the preparation thereof A compound comprising at least one cyclic amine, having an organolithium side-chain, defined according to formula (I) ##STR1## wherein Z is a lithium atom (Li); R1 is selected from the group consisting of organic groups containing from 1 t... | 06/15/1999 |
| 5885984 | Aminocyclohexylesters and uses thereof Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and com... | 03/23/1999 |
| 5869652 | Process for producing active substances from unused or discarded devices for the transdermal administration In a process for reprocessing devices for the transdermal application of active substances or their process waste, active substance-containing components are brought into solution and the active substances are recovered therefrom.... | 02/09/1999 |
| 5792820 | Alkyllithium compounds containing cyclic amines and their use in polymerization An organolithium compound according to the present invention containing a cyclic amino group, has the general formula: ##STR1## wherein R1 is a divalent alkylene, an oxy- or amino-alkylene, or substituted alkylene having from 6 to about 20... | 08/11/1998 |
| 5637583 | Aminocyclohexylesters and uses thereof Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and com... | 06/10/1997 |
| 5610227 | Lithium amino magnesiate polymerization initiators and elastomers having reduced hysteresis The present invention provides anionic polymerization initiators, comprising lithium amino magnesiate complexes, resulting in diene polymer and copolymer elastomers. The invention initiators have stable living ends at high polymerization temperatures and ... | 03/11/1997 |
| 5521309 | Tertiary-amino allyl-or xylyl-lithium initiators and method of preparing same An anionic polymerization initiator includes the C-lithio reaction product of an organolithium compound and a tertiary-amino allyllithium or a tertiary-amino xylyllithium. When used in an anionic polymerization, a functional group from the initiator is in... | 05/28/1996 |
| 5496940 | Alkyllithium compounds containing cyclic amines and their use in polymerization An organolithium compound according to the present invention containing a cyclic amino group, has the general formula: ##STR1## wherein R1 is a divalent alkylene, an oxy- or amino-alkylene, or substituted alkylene having from 6 to about 20... | 03/05/1996 |
| 5491230 | Anionic polymerization initiators containing adducts of cyclic secondary amines and conjugated dienes, and products therefrom An anionic polymerization initiator includes a carbon-lithio salt of the adduct of a cyclic secondary amine with a conjugated diene. A method of preparing an anionic polymerization initiator includes reacting an excess of a cyclic secondary amine with a c... | 02/13/1996 |
