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| Number | Title | Issue Date |
| 7291738 | Therapeutic compounds The present invention provides compounds, for example, of formula (I): wherein R1, R2, and R3 have any of the values defined in the specification, as well as pharmaceutical compos... | 11/06/2007 |
| 7285547 | Amidinophenylalanine derivatives as thrombin inhibitors The compounds of the formula (formula 1) and pharmaceutically acceptable salts thereof and a process for preparing the same and pharmaceutical compositions containing the same are described wherein the substituents have the meaning as specified in the description. T... | 10/23/2007 |
| 7241902 | Allylmercaptocaptopril compounds and uses thereof Compounds which are the reaction product of allicin and ACE-inhibiting compounds are useful in treating hypertension, elevated triglycerides, and elevated insulin. ... | 07/10/2007 |
| 7138547 | Antitumoral compounds New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, CN, halogen, C(═... | 11/21/2006 |
| 6927290 | Production of mixed acid anhydride and amide compound There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p (1) wherein R1, R2 and Y denote the same as defined below, n and p ... | 08/09/2005 |
| 6921822 | Process for stereoselectively reducing 4-aryl-4-oxobutanoic acid derivatives The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts. ... | 07/26/2005 |
| 6887866 | Short-acting sedative hypnotic agents for anesthesia and sedation The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals. ... | 05/03/2005 |
| 6887864 | Azepane derivatives This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as well as processes for their ... | 05/03/2005 |
| 6855706 | Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin. ... | 02/15/2005 |
| 6835831 | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors Disclosed is a method of preparing a composition comprising a compound represented Structural Formula (I): The method comprises the step of reacting an aldehyde compound R10CHO with an isonitrile compound re... | 12/28/2004 |
| 6790978 | Thyromimetic organic compounds Compounds of the present invention of the formula are thyromimetic agents which can be used to prevent and/or treat diseases associated with an imbalance of thyroid hormones, such as hypo- and hyper-thyroidism, obesity, ... | 09/14/2004 |
| 6677354 | Piperdines for use as orexin receptor antagonists Disclosed are compounds of formula (I): ##STR1## wherein: Y represents a group (CH2)n, wherein n represents 0, 1 or 2; R1 is phenyl, naphthyl, a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected ... | 01/13/2004 |
| 6653472 | Preparing amidines derived from 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid New intermediates of the formula (II)B described below for the synthesis of amidine derivatives of (-)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, such as for example (S)-N-{4-[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyra... | 11/25/2003 |
| 6602825 | 1-Aryl-1,3,5-triazine-4-thione-2,6-diones, production thereof and use thereof as herbicides Novel 1-aryl-4-thiotriazines I ##STR1## where the variables have the following meanings: R1 =H, NH2, C1 -C4 -alkyl, C1 -C4 -haloalkyl; R2 =H, NH2, C1 -C4 -... | 08/05/2003 |
| 6544986 | Pyridones and their use as modulators of serine hydrolase enzymes This invention relates to a compound of formula I: ##STR1## or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C.dbd.O or CH2 ; and R7 and R8 are... | 04/08/2003 |
| 6534536 | Alkylsulfonamido heterocyclic thrombin inhibitors Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl, aminoalkyl, alkyl, cycloalkyl, amidoalkyl, ... | 03/18/2003 |
| 6451824 | Sulfonylaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 09/17/2002 |
| 6423689 | Peptidyl calcium channel blockers The present invention provides compounds that block calcium channels having the Formula I shown below. ##STR1## The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy an... | 07/23/2002 |
| 6362174 | Reduced dipeptide analogues as calcium channel antagonitsts The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma. The nov... | 03/26/2002 |
| 6344466 | Benzamide and sulfonamide substitued aminoguanidines and alkoxyguanidines as protease inhibitors The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: ##STR1## wherein X is O or NH, L is --O-- or --SO2 --, and R1 -R4, R9 -R19, Ra... | 02/05/2002 |
| 6337394 | Compounds There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin... | 01/08/2002 |
| 6316440 | Reduced dipeptide analogues as calcium channel antagonists ##STR1## The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma... | 11/13/2001 |
| 6310246 | Fluorovinloxyacetamides, process for preparing same and herbicidal composition comprising same Herbicidal fluorovinyloxyacetamide compounds of formula (I) are useful for protecting crops from weeds: ##STR1## wherein: R1 is a phenyl group optionally having one or more substituents selected from the group consisting of C1-6 alky... | 10/30/2001 |
| 6251949 | Oxime derivatives, hydrazone derivatives and use thereof Compounds having fungicidal activities and represented by general formula (I) and salts and hydrates thereof ##STR1## wherein R1 represents an optionally substituted aryl, an optionally substituted alkyl or the like; R2 represents an... | 06/26/2001 |
| 6201126 | Isoindolenineamide dyestuffs Compounds of the formula (I) ##STR1## in which A represents N or a cyanomethylene radical, B represents S, O or NH and R1, R2, R3 and x have the meaning given in the description, are highly suitable for dyeing and printing high... | 03/13/2001 |
| 5945543 | Process for producing -(N,N dialkyl)-amino carboxlic acid amides A process for preparing -(N,N-dialkylamino) carboxamides of the formula I ##STR1## where the substituents have the stated meanings, comprises reacting the corresponding free acids with primary or secondary amines in the presence of anhydr... | 08/31/1999 |
| 5939437 | CCK and gastrin receptor ligands Compounds of formula (I) and their pharmaceutically active salts are gastrin and CCK receptor ligands, where Ar is a monocyclic aromatic group, R1 is halo, amino, nitro, cyano, sulphamoyl, sulphonyl, trifluoromethyl, C1 to C3 | 08/17/1999 |
| 5917034 | Antithrombotic n-amidinopiperidine and benzamidine derivatives Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates of either entity, wherein A is optionally monosaturated C1 -C4 alkylene optionaly monounsaturatred with C1 -C | 06/29/1999 |
| 5891876 | Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by AMPA receptors Compounds useful for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof, and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to ... | 04/06/1999 |
| 5859002 | HIV protease inhibitors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain the... | 01/12/1999 |
| 5856318 | Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for CNS disorders Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each o... | 01/05/1999 |
| 5852008 | Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors Compounds having the following structural formula, ##STR1## are useful for enhancing synaptic response mediated by AMPA receptors are disclosed, the invention compounds can also be used for the treatment of non-impaired subject for enhancing performa... | 12/22/1998 |
| 5846979 | N-oxides of heterocyclic esters, amides, thioesters, and ketones This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with... | 12/08/1998 |
| 5847159 | 1-ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same 1-ω-(3,4-Dihydro-2-naphthalenyl)alkyl!cyclic amine derivative of the formula (I): ##STR1## wherein R1 and R2 are H, halogen, OH, alkyl, alkoxy, hydroxymethyl, etc., or R1 and R2 combine to form meth... | 12/08/1998 |
| 5741799 | Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R1, R2, R3, G, Gx, R6', Ra, Xa, R6, Rb, R3, p, Q, A and R4 are as defined... | 04/21/1998 |
| 5741792 | Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R1, R2, R3, G, Gx, R6 ', Ra, Xa, R6, Rb, R3, p, Q, A and R4 are as define... | 04/21/1998 |
| 5693630 | Phenylethyl and phenylpropylamines Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R1 is a hydrogen atom, or a straight or branched C1-4 alkyl group,... | 12/02/1997 |
| 5637700 | Purification of caprolactam Caprolactam is purified by oxidative treatment in which mixtures which essentially contain the caprolactam to be purified and unsaturated lactams are treated with oxygen or an oxygen-containing gas mixture in an alkaline medium.... | 06/10/1997 |
| 5637701 | Process for preparing optically active amide derivatives A novel asymmetric synthesis is provided for preparing optically active amides of formula (A) and their salts. ##STR1## In the formula, X represent --N-- or --CH--, R represents a mono or bicyclic aryl or heteroaryl group, R1 is an aryl or... | 06/10/1997 |
| 5627283 | Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.... | 05/06/1997 |
