|7879999||Method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines|
The invention relates to a method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines The invention is characterised in that the method comprises a step consisting in demixing a solution contai...
Compounds of formula (I) have antibacterial activity; wherein Q represents a radical of formula —N(OH)CH(═O) or formula —C(═O)NH(OH); Y represents —C(═O)—, —C(═S)—, —S(═O)—, or —SO2—; R1 represents hydrogen, C...
|7147757||Method for separating an azepine derivative out of a mixture containing an amine an azepine derivative|
The invention relates to a method for separating by distillation a portion or the entirety of an azeptine derivative (III), which is selected from the group consisting of aminohexylidene imine, tetrahydroazepine, hexylhexahydroazepine and of aminohexylhexahydroazepi...
|7134245||Method and system for managing water infiltration at window openings|
A method is provided for managing water infiltrating a building at a window opening. The method includes, from an inside of the building, accessing a gap formed at a base of the window opening between a window sill and a horizontal window framing member. A flash pan...
The invention provides compounds of general formula (I) wherein m, n, Q, Z1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8
|6887352||Distillative method for separating hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine|
A method for recovering hexamethylene diamine (HMD) from a mixture comprising HMD, 6-aminocapronitrile (ACN) tetrahydroazepine (THA), and adiponitrile (ADN) is disclosed. The method includes introducing the mixture into a first distillation column, separating...
This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as well as processes for their ...
|6670368||Pyrimidine compounds with pharmaceutical activity|
A pyrimidine derivative of formula (I) wherein V is O or S, Q1 and Q2 are independently selected from phenyl, naphthyl, a 5- or 6-membered monocyclic moiety and a 9- or 10-membered bicyclic heterocyclic moiety; and Q1 is s...
|6667319||Neuropeptide Y Y5 receptor antagonists|
The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagoni...
|6555542||Sulfonamide lactam inhibitors of FXa and method|
Sulfonamide lactams of the following formula ##STR1## wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8 are as described herein, ...
|6534536||Alkylsulfonamido heterocyclic thrombin inhibitors|
Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl, aminoalkyl, alkyl, cycloalkyl, amidoalkyl, ...
|6514298||Fuel additive and fuel composition|
Fuel additives comprise a compound having a group represented by the formula >C.dbd.=N-- (1). Also disclosed are fuel compositions containing such additives. The additives have a superior detergent effect to conventional gasoline detergents and an excell...
|6495544||Homoiminopiperidinyl hexanoic acid inhibitors of inducible nitric oxide synthase|
Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed....
|6476054||Cyclic amine modulators of chemokine receptor activity|
The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R1, R2, R3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds a...
|6300497||Method for separating an azepine derivative from a mixture containing an amine and an azepine derivative|
A process for distillative removal of part or all of an azepine derivative (III) selected from the group consisting of aminohexylideneimine, tetrahydroazepine, hexylhexahydroazepine and aminohexylhexahydroazepine from a mixture (II) comprising an azepine ...
|5914351||Anti-viral aromatic hydrazones|
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a...
|5880286||Acetylation of sterically hindered diamines|
A process for acetylating diamines having a sterically hindered amino function and a further, sterically unhindered amino function where the acetylation takes place at the sterically unhindered amino function is provided comprises reacting the diamine wit...
|5856318||Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for CNS disorders|
Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each o...
|5854234||Amidino dervatives useful as nitric oxide synthase inhibitors|
The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors....
|5852009||Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon|
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target prote...
|5792820||Alkyllithium compounds containing cyclic amines and their use in polymerization|
An organolithium compound according to the present invention containing a cyclic amino group, has the general formula: ##STR1## wherein R1 is a divalent alkylene, an oxy- or amino-alkylene, or substituted alkylene having from 6 to about 20...
|5733934||Antiarrythmic and cardioprotective substituted indenoylguanidines|
Indenoylguanidines of formula I and formula II, the process for their preparation, their use as medicaments, medicaments containing them, their use as diagnostic agents and medicaments containing them are described. Compounds I are useful for treating car...
|5721255||Substituted benzylamino nitrogen containing non-aromatic heterocycles|
The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R1, R2, R3 and A are as defined in the ...
|5703065||Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds|
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein A, W, P, R3, Q and R1 are as defined herein. The compounds of formula I, and pharmaceutically acceptable salts ...
|5688804||3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor antagonists|
The present invention relates to the derivatives of the compound of formula (I), which are useful in the treatment of inflammatory and central nervous system disorders, as well as other diorders ##STR1##...
|5612332||Di- and triaminoguanidines, and methods of use|
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or tri-aminoguanidine capable of inhibiting the formation of adva...
A novel benzenesulfonamide derivative represented by the formula: ##STR1## has an inhibitory activity against phospholipase A2, so that it is effective in the treatment of diseases for which such an activity is efficacious....
|5519018||Substituted phenols and their use for the treatment of disorders caused by cell proliferation|
Substituted phenols of the formula I ##STR1## processes for their preparation and compositions containing substituted phenols of the formulae I and II ##STR2## for the treatment of disorders caused by cell proliferation, such as psoriasis, ...
|5423998||Peroxy carboxylic amino-derivatives|
Amino-derivative (poly)peroxycarboxylic acids which have the formula: ##STR1## wherein the symbols have the following meanings: R, R1, and R2, which may be equal to or different from one another, represent hydrogen atoms, alkyl ...
|5393762||Pharmaceutical agents for treatment of emesis|
The present invention relates to a method of treating or preventing emesis in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives and related compounds....
|5326911||Process for the preparation of ortho-amides|
Ortho-amides of the formula ##STR1## can be prepared by reacting salts of the formula ##STR2## with alcoholates of the formula M1 OR1 (III) where the radicals R1 to R4
|5232929||3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use|
The present invention relates to novel 3-aminopiperidine derivatives and related nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula ##STR1## wherein R1, R2, R3, R4, R
|5196439||Piperidine compounds useful to treat cerebrovascular diseases|
A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being --O--, --CO-- or --NH--, Z being phenyl, naphthyl, py...
|5189174||Heterocyclic thiol-based sulfenimide compounds|
Heterocyclic thiol sulfenimide compounds are useful as an accelerator in the curing of natural and/or synthetic rubbers. The compound can be represented by the formula ##STR1## wherein each of A1 and A2, independently, is at lea...
|5041545||2-hydroxybenzophenone hydrazides and derivatives thereof|
Hydrazide functionalized 2-hydroxybenzophenone ultraviolet light and heat stabilizers and derivatives are disclosed having the general formula: ##STR1## wherein R1, R2, R3, R4, R5, R6, X, Y...
|4906678||1,2,2,6,6-Pentamethyl-4-piperidylaminotriazine derivatives and their use as stabilizers|
Compounds of the formula (I) ##STR1## wherein R1 and R5 are independently hydrogen, C1 -C12 -alkyl, C5 -C7 -cycloalkyl or a group of the formula (II), ##STR2## R2, R
|4877874||Process for producing N-aminohexamethyleneimine|
There is disclosed a process for producing N-aminohexamethyleneimine, which comprises allowing hexamethyleneimine to react with hydroxylamine-O-sulfonic acid in the presence of an aqueous solvent and an inorganic base....
|4822792||Substituted 3-piperidinamines or 3-azepinamines, the preparation thereof and their applications in therapy|
Compounds of formula: ##STR1## in which R and R' each denote an alkyl or cycloalkyl radical having 1 to 7 carbon atoms; X denotes --O-- or H2 ; and Y and Z denote hydrogen or one or more radicals chosen from halogeno, hydroxy, straight or ...
|4774331||Process for ortho-cyanation of phenols or phenylamines|
A process for ortho-cyanation of phenols or phenylamines which comprises reacting a phenyl compound having hydroxy or optionally substituted amino or cyclic amino, of which ortho position is vacant, with trichloroacetonitrile, C1 -C5...
-amino acids having a substituted ω-guanidino group are disclosed herein....