Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 7910729 | Azulenyl nitrone spin trapping agents, methods of making and using same The present invention provides azulenyl nitrones, such as those having the following general formula: (I) compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine-med... | 03/22/2011 |
| 7405209 | Protease inhibitors The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such co... | 07/29/2008 |
| 7354771 | Method of determining absolute configuration of chiral compound The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulk... | 04/08/2008 |
| 7256186 | Gamma secretase inhibitors This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ... | 08/14/2007 |
| 7208602 | Gamma secretase inhibitors This invention discloses novel gamma secretase inhibitors of the formula: wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 ... | 04/24/2007 |
| 7202237 | Pyridylether derivatives, their preparation and use The present invention relates to novel pyridylether derivatives which are cholinergic ligands at nicotinic Ach receptors. The compounds of the invention are useful for the treatment of conditions, disorders, or diseases involving the cholinergic system of the centra... | 04/10/2007 |
| 7192953 | Antibacterial agents Compounds of formula (I) have antibacterial activity; wherein Q represents a radical of formula —N(OH)CH(═O) or formula —C(═O)NH(OH); Y represents —C(═O)—, —C(═S)—, —S(═O)—, or —SO2—; R1 represents hydrogen, C... | 03/20/2007 |
| 7157398 | Covalently fixed nonmetallocenes, process for preparing them and their use for the polymerization of olefins The invention relates to a method for producing special transition metal compounds, to novel transition metal compounds and to the use thereof for polymerizing olefins. ... | 01/02/2007 |
| 7071184 | Protease inhibitors The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel int... | 07/04/2006 |
| 6960574 | Antagonists of RF-amide neuropeptides Disclosed are compounds having the formula: where R1=H, C1-C6 alkyl, cycloalkyl, R2... | 11/01/2005 |
| 6914140 | Asymmetric synthesis process A novel process for the manufacture of compounds of the formula wherein R1 and R2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel p... | 07/05/2005 |
| 6887864 | Azepane derivatives This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as well as processes for their ... | 05/03/2005 |
| 6849203 | Photoisomerizable compounds The invention relates to photoisomerizable compounds of formula I wherein A, Z, L, R, R1, k, m and r are defined herein. ... | 02/01/2005 |
| 6849619 | Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, ... | 02/01/2005 |
| 6841667 | Nucleophilic kinetic resolution of cyclic substrates using silyl azides The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisome... | 01/11/2005 |
| 6821965 | Amidobenzamide derivatives which are useful as cytokine inhibitors The invention concerns amide derivatives of the Formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluor... | 11/23/2004 |
| 6800766 | Hydrolytic kinetic resolution of cyclic substrates The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisome... | 10/05/2004 |
| 6797707 | Antagonists of RF-amide neuropeptides Disclosed are compounds having the formula: where R1=H, C1-C6 alkyl, cycloalkyl, R2=H, C1-C6 alkyl, cycloalkyl | 09/28/2004 |
| 6759430 | Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2−) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothelial dysf... | 07/06/2004 |
| 6699852 | Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) ##STR1## or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9... | 03/02/2004 |
| 6673920 | Method for the production of N-alkenyl-amides A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst diols of the general formula (I) ... | 01/06/2004 |
| 6624303 | Method for producing N-alkenyl amides A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst compounds of the general formulae (I... | 09/23/2003 |
| 6579889 | Substituted isonipecotyl derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 06/17/2003 |
| 6534536 | Alkylsulfonamido heterocyclic thrombin inhibitors Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl, aminoalkyl, alkyl, cycloalkyl, amidoalkyl, ... | 03/18/2003 |
| 6495544 | Homoiminopiperidinyl hexanoic acid inhibitors of inducible nitric oxide synthase Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.... | 12/17/2002 |
| 6462193 | Hydroxyazepanes as inhibitors of glycosidase and HIV protease Hydroxyazepanes display inhibitory activity with respect to glycosidase, with Ki values from-moderate to low micromolar range. Benzyl and 3,6-dibenzyl derivatives of hydroxyazepanes display inhibitory activity with respect to HIV protease. Thes... | 10/08/2002 |
| 6462073 | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 10/08/2002 |
| 6451789 | 1-aza-2-alky-6-aryl-cycloalkanes Compound of formula (I): ##STR1## wherein: n represents 0 or 1, R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or trifluoroacetyl, R2 represents alkyl, X represents oxygen, chlorine, OR3, SR | 09/17/2002 |
| 6448414 | Hydrolytic kinetic resolution of cyclic substrates The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a ... | 09/10/2002 |
| 6448267 | Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2-) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothe... | 09/10/2002 |
| 6440588 | Nitrogen-containing heterocyclic compound and electroluminescent device A nitrogen-containing heterocyclic compound represented by the following formula (I) or (II): ##STR1## wherein X1 and X2 are the same or different, each representing a hydrogen atom, an alkyl group, or an electron attractive group an... | 08/27/2002 |
| 6403584 | Substituted nipecotyl derivatives as inhibitors of cell adhesion Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 06/11/2002 |
| 6335329 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharm... | 01/01/2002 |
| 6291450 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharm... | 09/18/2001 |
| 6262278 | Stereoselective ring opening reactions The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a ... | 07/17/2001 |
| 6174879 | Aminocyclohexylesters and uses thereof Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and com... | 01/16/2001 |
| 6136969 | Azepanes Compounds of the formula ##STR1## wherein R1 is phenyl or alpha- or beta-naphthyl, which groups can be substituted by hydroxy, lower-alkyl, lower-alkoxy, lower alkoxy-carbonyl, phenoxy, acyloxy, hydroxyphenoxy-sulfonyl, halogen, nitro, ami... | 10/24/2000 |
| 6107291 | Azepine or larger medium ring derivatives and methods of use Selected novel azepine and larger medium ring compounds are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salt... | 08/22/2000 |
| 6087379 | Cyclic amine derivatives A cyclic amine derivative represented by the following formula: ##STR1## wherein R1 represents a substituted or unsubstituted phenyl group, R2 represents a substituted of unsubstituted C1 -C8 aliphatic acyl... | 07/11/2000 |
| 6069245 | Asymmetric synthesis of azepines A novel process for the manufacture of compounds of the formula ##STR1## wherein R1 and R2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel process for making compounds of ... | 05/30/2000 |
