Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 8168782 | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor agonists for the treatment of, f... | 05/01/2012 |
| 7429579 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) The invention provides compounds of formula (I): wherein: R2 and R3 independently represent various substituents; R1 and R4 independently represent H, F, Cl, Br, C1-2alkyl, C1alkoxy, OH, CN, or NO | 09/30/2008 |
| 7304050 | Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a... | 12/04/2007 |
| 7229986 | Melanin-concentrating hormone antagonist A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms... | 06/12/2007 |
| 7173023 | Bicyclic compounds The present invention relates to novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X′, Y and Y′ are as defined in... | 02/06/2007 |
| 7122538 | Sulfonamide derivatives as antipsychotic agents The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 | 10/17/2006 |
| 7008938 | Benzene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient A benzene-fused heteroring derivative of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cyst... | 03/07/2006 |
| 7008940 | Dihydrobenzofuran derivatives, process for the preparing thereof and agents A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherei... | 03/07/2006 |
| 6919332 | N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R1 are as defined in the specification, and to pharmac... | 07/19/2005 |
| 6916811 | Adenosine A2a receptor antagonists Disclosed herein are compounds having the structural formula A including pharmaceutically acceptable salts or solvates of said compound, wherein X, Y, Q and R are as defined in the specification; pharmaceutical composi... | 07/12/2005 |
| 6861420 | N-substituted 1,2,4,5-tetrahydro-1H-benzo[d]azepine compounds The present invention provides compounds of Formula I: wherein X, R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, as wel... | 03/01/2005 |
| 6818652 | Heterocyclic retinoid compounds The current invention provide novel heterocyclic retinoid compounds, methods of treating or preventing chronic obstructive pulmonary disease, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of these disorders... | 11/16/2004 |
| 6649606 | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity Tetrahydroisoquinoline analogs are provided which are modulators of chemokine receptor activity. The tetrahdroisoquinoline analogs thereof have the structure ##STR1## wherein R1, R2, R3, R3a, X1, X2 | 11/18/2003 |
| 6605607 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) Compounds of Formula I ##STR1## and their salts having affinity for dopamine receptors, in particular the D3 Receptor, and thus potential in the treatment of conditions wherein modulation of the D3 receptor is beneficial, e.g., as ... | 08/12/2003 |
| 6602864 | Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibit... | 08/05/2003 |
| 6586422 | Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine The invention relates to compounds which are represented by the formula ##STR1## wherein R1, R2, R3, R4, X and Y are as defined in the specification, as well as pharmaceutically acceptable salts thereof. The inv... | 07/01/2003 |
| 6534650 | Benzisoxazole and 4-amidino-3-hydroxyphenyl chemical intermediates This invention relates to compounds of Formula V H--Y--G--R V and Formula VI ##STR1## (wherein f, X, Y, G and R have the values defined in the description) which are useful as intermediates for the preparation of compounds, or pharmaceutically acceptabl... | 03/18/2003 |
| 6534496 | Thermogenic composition and benzazepine thermogenics The object of the present invention is to provide a prophylactic and/or therapeutic drug for obesity and obesity-associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the present inv... | 03/18/2003 |
| 6350760 | Substituted piperidines as melanocortin-4 receptor agonists Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention ... | 02/26/2002 |
| 6346527 | Guanidine derivatives A compound of the formula: ##STR1## wherein R1 is hydrogen or halogen, R2 is hydroxy, acyl(lower)alkoxy, hydroxy(lower)alkyl, lower alkoxy(lower)alkyl, lower alkylthio(lower)alkyl, mono(or di or tri)halo(lower)alkyl, (ethoxycarbonyl)... | 02/12/2002 |
| 6303593 | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine ... | 10/16/2001 |
| 6281227 | Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibit... | 08/28/2001 |
| 6218385 | 1,2,4,5-Tetrahydro-benzo[D]azepin derivatives The present invention is concerned with 1,2,4,5-tetrahydro-benzo[d]azepin derivatives as well as with their pharmaceutically acceptable salts in their racemic and optically active form, which compounds are antagonists at metabotropic glutamate receptors a... | 04/17/2001 |
| 6107308 | Piperidine derivatives The present invention is directed to a piperidine derivative represented by the following formula (1) or a salt thereof: ##STR1## wherein R1, R2, and R3 individually represent hydrogen atoms, etc., Y represents #... | 08/22/2000 |
| 6069114 | 2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators Compounds of the formula (I) and their salts ##STR1## in which R1 to R6, Y1, to Y2, Y3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepa... | 05/30/2000 |
| 5973188 | Acetic acid derivatives Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets an... | 10/26/1999 |
| 5939412 | Bicyclic fibrinogen antagonists Compounds of the formula: ##STR1## wherein A1 to A5 form a seven-membered ring containing one optionally substituted nitrogen atom; D1 to D4 form a substituted six membered ring, optionally containing up to... | 08/17/1999 |
| 5914319 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations contain... | 06/22/1999 |
| 5885967 | Antithrombotic agents This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.... | 03/23/1999 |
| 5861393 | Antithrombotic amidinophenylalanine and amidinopyridylalanine derivatives This invention relates to compounds of formula (I), ##STR1## pharmaceutically acceptable salt thereof, and pharmaceutically acceptable solvates of either entity, wherein X is CH or N; Y is optionally monousaturated C3 -C5 alkyle... | 01/19/1999 |
| 5811552 | Cyclobutenedione derivative, process for preparing the same, and nonlinear optical element A novel cyclobutenedione derivative prepared in accordance with the following reaction formula, a process for the preparation thereof, and a nonlinear optical element comprising such a derivative are provided: ##STR1## wherein R1 and R | 09/22/1998 |
| 5807886 | Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase Compounds of the formula (I) ##STR1## wherein D represents a 5-membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro, cyano... | 09/15/1998 |
| 5798352 | Antithrombotic amidinotetrahydropyridylalanine derivatives This invention is directed to compounds of formula (I), ##STR1## pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates of either entity, wherein Y is optionally monounsaturated C3 -C5 alkylene optio... | 08/25/1998 |
| 5753644 | Vasopressin antagonist and oxytocin antagonist An object of the present invention is to provide a vasopressin antagonist and oxytocin antagonist. The vasopressing antagonist and oxytocin antagonist according to the present invention contain, as the active ingredient, a benzoheterocyclic compound repre... | 05/19/1998 |
| 5744472 | 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein the 6-membered A ring may be optionally substituted with up to four groups independently selected from halogen, hydroxy, lower alkyl, or lower al... | 04/28/1998 |
| 5736534 | 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents This invention relates to certain 4-aminoquinazolines and the pharmaceutically acceptable salts and stereoisomers thereof, the formula whereof are described herein. The compounds are useful for the treatment of hyperproliferative diseases, particularly as... | 04/07/1998 |
| 5726159 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 03/10/1998 |
| 5710130 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 01/20/1998 |
| 5707967 | Pain relief compositions Disclosed are compositions containing either aspartame or monosodium glutanate combined with an amino acid.... | 01/13/1998 |
| 5707966 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 01/13/1998 |
