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Class 540/592 - Nitrogen attached indirectly to ring nitrogen of the hetero ring by acyclic nonionic bonding


Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein nitrogen is attached indirectly to the
No. of patents: 32
Last issue date: 06/06/2006


NumberTitleIssue Date
7056911Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof
The invention relates to pharmaceutically active compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention and particularly useful for the treatment or prophylaxis of diseases ...
06/06/2006
6908915Tricyclic compounds and their uses as antiarrhythmic antifibrillatory and defibrillatory agents
A compound having a general formula (II) wherein R1 is saturated or unsaturated alkyl, amino-alcohol, diamino, cycloalkyl, and C(═O)(CH2)nNR′R″, (CH2)nCHOHCH2NR′R″, wherein n is an integer, ...
06/21/2005
6569849N-Substituted azaheterocyclic compounds
The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, A, R1, R2, r and s are as defined in the detailed part of the present description or salts thereof, to me...
05/27/2003
63842175-CYANO-10-HYDROXY-10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE, THE PROCESSES FOR ITS PREPARATION AND FOR ITS CONVERSION INTO 5-CARBAMOYL-10-OXO-10, 11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE OR INTO 5-CARBAMOYL-5H-DIBENZ[B,F]AZEPINE
5-Cyano-10-Hydroxy-10,11-Dihydro-5H-Dibenzi[b,f]azepine and the process for its preparation....
05/07/2002
6214816Heterocyclic compounds
The compounds are N-substituted azaheterocyclic compounds of formula I ##STR1## wherein R1 and R2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C1-6 -alkyl or C1-6 -alkoxy; and Y is >N--CH2...
04/10/2001
6071901Substituted dibenz[b,f]azepines and uses thereof
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids andy esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing the...
06/06/2000
60403021,4-disubstituted piperazines
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their ...
03/21/2000
5929235Aromatic tertiary amine compound having benzazepine structures
An aromatic tertiary amine compound of formula (I): ##STR1## wherein (A) and (B) are each a substituted or unsubstituted vinylene or o-arylene group; R1 to R4 are each a halogen atom, or a substituted or unsubstituted alkyl, ary...
07/27/1999
59168891,4-disubstituted piperazines
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their ...
06/29/1999
5731307Neuroleptic 2,7-disubtituted perhydro-1h-pyrido›1, 2-A!pyrazines
The instant invention is directed to compounds, compositions and antipsychotic methods of use wherein the compounds are of formula I: ##STR1## wherein Y is an imide or benzoyl alkyl group and X is a cycloalkyl, phenyl or dibenzoazepinyl group....
03/24/1998
5721254N-substituted azaheterocyclic carboxylic acids and esters thereof
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them...
02/24/1998
5716949Heterocyclic compounds
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them...
02/10/1998
5712269M2 receptor ligand for the treatment of neurological disorders
Muscarinic M2 receptor ligands are described which are suitable for the treatment of neurological disorders, and which may be administered with minimal side-effects. A method of synthesis of these compounds is also described....
01/27/1998
5693649N-substituted azaheterocyclic carboxylic acids and esters thereof
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them...
12/02/1997
5688788N-substituted azaheterocyclic carboxylic acids and esters thereof
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them...
11/18/1997
5668129N-substituted azaheterocyclic carboxylic acids and esters thereof
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them...
09/16/1997
5629421Hydrazone compounds
There are provided a hydrazone compound represented by formula (I), an electrophotographic photoreceptor which has a photosensitive layer containing the compound on an electrically conductive support, and an organic electroluminescent element containing t...
05/13/1997
5614419Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids
Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of the Formula III: ##STR1## wherein ...
03/25/1997
5599815Antipsychotic benzoisothiazolyl piperazine derivatives
Compounds represented by the formula (I) and pharmacologically acceptable salts thereof: ##STR1## These compounds have little extrapyramidal effect and thus are effective as an anti-psychotic agent having few side effects....
02/04/1997
5599929Method for preparing opipramol
An improved method for preparing opipramol (I) is disclosed, wherein iminostilbene (II) is reacted with 1-bromo-3-chloropropane in the presence of a weak base selected from a hydrogen phosphate salt and an acetate salt and in the presence of a phase trans...
02/04/1997
5595989N-substituted azaheterocyclic carboxylic acids and esters thereof
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them...
01/21/1997
5578500Reagents and methods for the quantification of imipramine or desipramine in biological fluids
Immunoassay methods and reagents for the specific quantification of imipramine or desipramine in a test sample are disclosed. The measurement of imipramine or desipramine is accomplished in a specific immunoassay employing antibodies prepared with imipram...
11/26/1996
5569653N-[(4-(heteroaryl)-1-pyrrolidinyl)al kyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D...
10/29/1996
5208330Fused heteroalkylene quinolinamines
There are disclosed compounds having the formula ##STR1## wherein n is 1-4; R is hydrogen, loweralkyl or loweralkylcarbonyl; R1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralky...
05/04/1993
5204348Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components
Novel heterocyclic compounds, which are represented by the following general formula, useful as anticancer drug potentiaters having a potentiating effect on the incorporation of anticancer drugs into cancer cells, the compounds each synthesized by, for ex...
04/20/1993
5182387Bis-dibenzoazepine compounds
Novel bis-dibenzoazepine compounds useful in the treatment of malaria and drug-resistant malaria....
01/26/1993
4847374Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
N,N-(dibenzohexatrienylene)urea medicaments can be manufactured in a smooth one-step reaction by reacting a corresponding N,N-(dibenzohexatrienylene)amine with cyanic acid....
07/11/1989
4772697Tricylic antidepressant conjugates to antigens and enzymes
Tricyclic antidepressant functionalized compounds are provided for conjugation through a side chain to antigenic compounds, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies and together wi...
09/20/1988
4668671Tricyclic derivatives and pharmaceutical use
This invention describes tricyclic derivatives which are useful as histamine H1 -antagonists. A particular compound of this invention is 3-[3-(pyrido[3,2-b][1,4]-benzothiazin-10-yl)propylamino]-4-(pyrid-4-ylmeth ylamino)-1,2,5-thiadiazole-1-oxid...
05/26/1987
4551275Desmethylimipramine derivatives and poly(amino acid) conjugates
Desmethylimipramine functionalized compounds are provided for conjugation to antigenic compounds, particularly poly(amino acids) and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays...
11/05/1985
4436660Process for the production of 5-cyano-and 5-carboxamido-5H-dibenz[b,f]azepines
The invention relates to a novel and technically advanced process for producing 5-cyano-5H-dibenz[b,f]azepine by reacting 5H-dibenz[b,f]azepine with a halocyanogen in the presence of strongly polar substances. 5-Cyano-5H-dibenz[b,f]azepine can be used as ...
03/13/1984
4172074Preparation of an antidepressant
The present invention relates to a new and improved method for the preparation of the hydrochloride of 4'-chloro-2-{(3-(10,11-dihydro-5H-dibenz[b,f]azepinyl-(5))-propyl)-methyl- amino}-acetophenone, in the following called lofepramine hydrochloride. In ...
10/23/1979
 
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