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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 8110680 | Optically active quaternary ammonium salt having axial asymmetry, and method for producing alpha-amino acid and derivative thereof by using the same The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the pre... | 02/07/2012 |
| 7863443 | Phosphoramidite ligand and production method of allylic amine using the same The present invention provides a production method of an allylic amine represented by the formula (III): wherein R3 is as defined in the specification, which comprises reacting by an allylic alcohol rep... | 01/04/2011 |
| 7858778 | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[B,F]azepine-5-carboxyamide A process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxyamide by hydrolysis of 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine with peroxy compounds in alkali medium and in the presence of solvents. ... | 12/28/2010 |
| 7442790 | Caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; between R3 and... | 10/28/2008 |
| 7329653 | Cyclohexylphenyl vasopressin agonists The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl; “Z” represents optionally substituted phenyl or a 6-membered aromatic rin... | 02/12/2008 |
| 7196193 | Method for preparing 6-aminomethyl-6, 11-dihydro-5h-dibenz[b,e]azepine A production method of 6-aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepin characterized in that said compound is produced via N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is prepared by reducing 2-(11H-dibenz[b,e]azepin-6-ylmethyl)-... | 03/27/2007 |
| 6992079 | Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards t... | 01/31/2006 |
| 6979414 | Organic electroluminescence element An organic electroluminescence element comprising: an anode layer, a cathode layer, and an organic luminescence layer therebetween, the organic luminescence layer having a carbazole derivative with a glass-transition temperature of 110° C. or higher, and a phosphor... | 12/27/2005 |
| 6878822 | Ethylene derivative having a nitrogen-containing 7-membered ring A compound represented by formula (IA): in which (A) represents an ethylene group, a vinylene group or an o-arylene group; Ar1 and Ar2 each represent an aryl group; R1 and R2 | 04/12/2005 |
| 6770668 | Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihydrophenanthr... | 08/03/2004 |
| 6534497 | Substitute 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 11-phenyl-dibenzazepine compounds that are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach... | 03/18/2003 |
| 6387544 | OLEDS containing thermally stable glassy organic hole transporting materials Organic light emitting devices comprising a heterostructure for producing electroluminescence having a hole transporting layer with a glass structure. The hole transporting layer comprises a compound having a symmetric molecular structure. The end groups ... | 05/14/2002 |
| 6201120 | Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula: ##STR1## and a starting material represented by the following structural formula: ##STR2## ... | 03/13/2001 |
| 6172058 | Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cyclo... | 01/09/2001 |
| 6066632 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts thereof, to me... | 05/23/2000 |
| 6063921 | Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula: ##STR1## and a starting material represented by the following structural formula: ##ST... | 05/16/2000 |
| 6057441 | Substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and q are zero to 4; r is zero to 5; R1 and R | 05/02/2000 |
| 6048856 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the formula ##STR1## wherein X, Y, R1, R1a, R2, R2a, R12, R13, A, r and s are as defined in the detail... | 04/11/2000 |
| 6008213 | Integrin receptor antagonists Compounds of formula (I) ##STR1## wherein A1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R3 or R4 ; X1 --X2 is CHR1 -... | 12/28/1999 |
| 5952501 | Certain tricyclic substituted diazabicylo3.2.1! octane derivatives This invention encompasses compounds of the formula: where either R1 or R2 represents ##STR1## and the other represents hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms; and X is oxygen, methylene, or N... | 09/14/1999 |
| 5929069 | Compounds activating pharmacological effects of retinoids A compound represented by the formula (I) or (II) or a salt thereof wherein R1 represents hydrogen atom or a C1-6 alkyl group; R2 and R3 independently represent a hydrogen atom or a C1-6 alkyl group, ... | 07/27/1999 |
| 5919780 | Tricyclic inhibitors of protein farnesyltransferase Compounds of formula I ##STR1## wherein X is N or C--R9, Y is N--R10, CH2, O, S, SO, SO2, C.dbd.O or CH--OH, R is H or alkyl, R1 is heteroaryl, n is 1-5, and R2 -R10 are H or var... | 07/06/1999 |
| 5869483 | Tricyclic benzazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati... | 02/09/1999 |
| 5834459 | Alkyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH | 11/10/1998 |
| 5753643 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 05/19/1998 |
| 5686466 | Tricyclic condensed heterocyclic compounds their production and use A novel compound of the formula: ##STR1## wherein Ar represents an optionally substituted tricyclic condensed benzene ring group which includes at least one heterocyclic ring as a component ring; n represents an integer from 2 to 10; R1 re... | 11/11/1997 |
| 5679679 | Aralkyl diazabicycloalkane derivatives for CNS disorders Certain aralkyl diazabicyloalkyl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein: each of R1, R4,... | 10/21/1997 |
| 5602120 | Benzyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select... | 02/11/1997 |
| 5602124 | 5-HT2 receptor ligands Described herein are 5-HT2 receptor-selective compounds of Formula I: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH | 02/11/1997 |
| 5594152 | Process for the preparation of tricyclic-heterocycles This invention comprises a process for production of a compound of the formula: ##STR1## in which R1 is selected from the group consisting of H, lower alkyl(C1 -C3), alkoxy(C1 -C3), bromo, chloro... | 01/14/1997 |
| 5552399 | Substituted tetracyclic azepine derivatives This invention concerns the compounds of formula (I), the pharmaceutically acceptable salts and stereoisomeric forms thereof, and also the N-oxide forms thereof. ##STR1## wherein: R1 and R2 each independently are hydrogen; C | 09/03/1996 |
| 5527800 | Tricyclic condensed heterocyclic compounds, their production and use A novel compound of the formula: ##STR1## wherein Ar represents an optionally substituted tricyclic condensed benzene ring group which includes at least one heterocyclic ring as a component ring; n represents an integer from 2 to 10; R1 re... | 06/18/1996 |
| 5512563 | Tricyclic benzazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati... | 04/30/1996 |
| 5488046 | Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2... | 01/30/1996 |
| 5457122 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, possess an antagonistic activity on leukotriene B4.... | 10/10/1995 |
| 5436333 | Process for the preparation of tricyclic-heterocycles Compounds of the formula: ##STR1## in which R1 is H, C1 -C3 alkyl, C1 -C3 alkoxy, amino, bromo, chloro, fluoro, iodo, C1 -C3 alkylcarbonyl or trifluoromethyl; R2 ... | 07/25/1995 |
| 5344828 | Piperazinealkanoic acid and a pharmaceutical composition comprising the same Novel polycyclic compounds represented by the following formula: A--(CH2)n --COOR1, wherein R1 represents a hydrogen atom or a lower alkyl group; n represents an integer of from 0 to 5; and A is a group represen... | 09/06/1994 |
| 5244881 | Compositions based on imipyramine The invention provides new inclusion compounds based on imipramine and cyclodextrin and pharmaceutical compositions which can be administered orally and are based on these new inclusion compounds.... | 09/14/1993 |
| 5216178 | Process of reducing olefins Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds ar... | 06/01/1993 |
| 5192760 | 3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines and method for their making New 3-carbalkoxyamino-5-(alpha-aminopropionyl)-5H-dibenz[b,f]azepines of formula I and their pharmaceutically acceptable salts were found to be suitable actives for the treatment of cardiac arrhythmia. Previously unknown 3-carbalkoxyamino-5-(alpha-ha... | 03/09/1993 |
