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| Number | Title | Issue Date |
| 7407949 | Benzamide derivatives as oxytocin agonists and vasopressin antagonists Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds ... | 08/05/2008 |
| 7365062 | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, wh... | 04/29/2008 |
| 7326700 | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention a... | 02/05/2008 |
| 7238687 | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specif... | 07/03/2007 |
| 7202239 | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides novel tricyclic benzodiazepine carboxamides compounds and methods and pharmaceutical compositions utilizing them for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antago... | 04/10/2007 |
| 7196076 | Androgen receptor modulators and methods of use thereof Compounds of structural formula (I) are disclosed as useful for modulating the androgen receptor (AR) in a tissue selective manner in a patient in need of such modulation, and in particular for antagonizing AR in the prostate of a male patient or in the uterus of a ... | 03/27/2007 |
| 7109193 | Tricyclic diazepines tocolytic oxytocin receptor antagonists This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist ac... | 09/19/2006 |
| 7067519 | 7,8,9,10-tetrahydro-6-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2-pyrrolo[2,1-]-quinazolinone derivatives The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns re... | 06/27/2006 |
| 7064120 | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists This invention provides novel substituted tricyclic pyridyl carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or pr... | 06/20/2006 |
| 7022729 | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of tr... | 04/04/2006 |
| 7022699 | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators The present invention provides novel tricyclic diazepine compounds and methods and pharmaceutical compositions utilizing them for the treating or preventing disorders including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coag... | 04/04/2006 |
| 7012144 | Quinolone carboxylic acid derivatives Quinolone carboxylic acid derivatives of formula (I) and pharmaceutically acceptable salts thereof have potent antibacterial activity: wherein, R1 is a C1-4 alkyl... | 03/14/2006 |
| 7001898 | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specificatio... | 02/21/2006 |
| 6992078 | Plant extracts and alkaloids having antitussive activity The present invention provides plant extracts, isolated alkaloids, synthetic alkaloids and compositions having antitussive activity. In some preferred embodiments, the plant extracts and the isolated alkaloids are from a plant of a genus in the family Stemonaceae... | 01/31/2006 |
| 6953791 | Dipeptide derivatives This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which inc... | 10/11/2005 |
| 6953787 | 5HT2C receptor modulators The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.... | 10/11/2005 |
| 6872718 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents A compound represented by the formula: wherein Ring A is a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, Ring B is benzene ring which is further substituted, Ring... | 03/29/2005 |
| 6800656 | Tricyclic compounds and method of treating herpes virus The present invention provides a compound of the formula and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. Wherein: X=O, (CH2)m, S, ... | 10/05/2004 |
| 6610685 | Fused indole derivatives The present invention is a chemical compound of formula (I) ##STR1## or a pharmaceutically acceptable salt, solvate and ester thereof, wherein R1 to R4 and n are as defined in the specification. A compound of formula 1 is useful as a... | 08/26/2003 |
| 6583134 | Aza- indolyl derivatives for treating obesity Novel compounds of formula (I): ##STR1## wherein X1, X2, X3 and X4, n, R1, R2 and R3 are defined in the specification, and pharmaceutically acceptable salts and prodrugs of the c... | 06/24/2003 |
| 6380184 | Benzoazepines and analogs thereof useful as growth hormone secretagogues Benzoazepines of the following formula ##STR1## wherein R1, R1a, R2, R9k, L, Q, X, Y and Z are as described herein, and analogs thereof are provided which are useful in stimulating endogenous production or relea... | 04/30/2002 |
| 6369221 | Thiazolobenzoheterocycles, preparation and medicines containing same Disclosed are thiazolobenzoheterocycles of the general formula ##STR1## Including their isomers, racemates, enantioners and salts thereof, as well as processes for preparing these compounds and medicaments containing them. Also disclosed are novel interme... | 04/09/2002 |
| 6235730 | 3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions comprising the same 3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): ##STR1## wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstitu... | 05/22/2001 |
| 6235900 | Tricyclic pyridine N-oxides vasopressin agonists The present invention provides compounds of the general formula: ##STR1## as well as methods and pharmaceutical compositions utilizing these compounds for the inducement of temporary delay of urination or the treatment of disorders which may be remedied o... | 05/22/2001 |
| 6133255 | Tricyclic pyridone analogues as GABA-A receptor ligands Tricyclic pyridin-2-one analogues which are ligands for GABAA receptors, are useful in the therapy of deleterious mendtal states, and are represented by the formula: ##STR1##... | 10/17/2000 |
| 6043238 | 2-Aminobenzazapine derivatives A compound of the formula ##STR1## wherein a, V, X, Y, Z, R1, R2, R3 and R4 are as defined above, useful in (a) the treatment of myelosuppression including suppression associated with cancer chemotherapy as... | 03/28/2000 |
| 5998409 | Condensed indole derivatives as 5HT4 -receptor antagonists Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.... | 12/07/1999 |
| 5998405 | Fused tropane-derivatives as neurotransmitter reuptake inhibitors The present invention discloses compounds of the formula, or any of its enantiomers or any mixture thereof, a pharmaceutically acceptable addition salt thereof or the N-oxide thereof wherein X and Y together forms .dbd.O, .dbd.S, .dbd.NOR2, .dbd.CR | 12/07/1999 |
| 5977100 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof A substituted guanidine derivative represented by the general formula: ##STR1## wherein R1, R2, R3 and R4 are independently a hydrogen atom, an unsubstituted alkyl group, a substituted alkyl group, a halogen ... | 11/02/1999 |
| 5962447 | Benzoxazines for enhancing synaptic response Compounds based on the benzoxazine ring system are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to de... | 10/05/1999 |
| 5919780 | Tricyclic inhibitors of protein farnesyltransferase Compounds of formula I ##STR1## wherein X is N or C--R9, Y is N--R10, CH2, O, S, SO, SO2, C.dbd.O or CH--OH, R is H or alkyl, R1 is heteroaryl, n is 1-5, and R2 -R10 are H or var... | 07/06/1999 |
| 5852014 | Condensed indole derivatives as 5HT4 -receptor antagonists Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.... | 12/22/1998 |
| 5834461 | Tricyclic benzazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati... | 11/10/1998 |
| 5789402 | Compounds having effects on serotonin-related systems A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the sym... | 08/04/1998 |
| 5770382 | Tricyclic retinoids, methods for their production and use Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.... | 06/23/1998 |
| 5770378 | Tricyclic retinoids, methods for their production and use Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.... | 06/23/1998 |
| 5741789 | Compounds having effects on serotonin-related systems A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the sym... | 04/21/1998 |
| 5736538 | Tricyclic Benzazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati... | 04/07/1998 |
| 5731307 | Neuroleptic 2,7-disubtituted perhydro-1h-pyrido1, 2-A!pyrazines The instant invention is directed to compounds, compositions and antipsychotic methods of use wherein the compounds are of formula I: ##STR1## wherein Y is an imide or benzoyl alkyl group and X is a cycloalkyl, phenyl or dibenzoazepinyl group.... | 03/24/1998 |
| 5723633 | Pyran derivative, photosensitive resin composition, and hologram recording medium using it A pyran derivative has a structure of R2 R3 C.dbd.(C5 H2 R1 O)--(CH.dbd.CH)n --C6 H2 R6 R7 --NR4 R5 wherein n is 3 or 4; R1 | 03/03/1998 |
