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| Number | Title | Issue Date |
| 7314870 | Compounds, their preparation and use The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention ... | 01/01/2008 |
| 7241887 | 3-azabicyclo[3.2.1]octane derivatives The subject invention relates to 3-azabicyclo[3.2.1]octane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject inventio... | 07/10/2007 |
| RE39558 | 5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis Compounds of this formula are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease. ... | 04/10/2007 |
| 7176198 | 1-pyrazole and 1-pyrrole-azabicyclic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is where the variables have the definitions discussed herein. These compounds may be in the... | 02/13/2007 |
| 7067515 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease The invention provides compounds of Formula I: where in W is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or... | 06/27/2006 |
| 6919359 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: Azabicyclo-N(R1)—C(═X)—W Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Fo... | 07/19/2005 |
| 6852716 | Substituted-aryl compounds for treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmac... | 02/08/2005 |
| 6509356 | 1-(4-(Substituted alkoxy)benzyl)naphthalene compounds having estrogen inhibitory activity A class of substituted benzylnaphthylene compounds of the structure ##STR1## where R1 and R2 are independently hydrogen, alkyl of one to six carbon atoms, acyl of two to six carbon atoms, or phenacyl; X is --(CH2)1-6 | 01/21/2003 |
| 6051575 | Piperazino derivatives as neurokinin antagonists The invention relates to compounds of the formula ##STR1## wherein Z, Rc, y, m, u, Ar2, n, X, Rc', I and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful i... | 04/18/2000 |
| 5744607 | Basic derivatives of glutamic acid and aspartic acid as gastrin or cholecystokinin antagonists The invention is directed to glutamic acid and aspartic acid derivatives represented by formula (I): ##STR1## wherein R1 is selected from the group consisting of unsubstituted, mono- or di-substituted phenyl groups, unsubstituted, mono- or... | 04/28/1998 |
| 5612336 | Heterocyclic amide derivatives as tachykinin antagonists Compounds of formula (I), and salts and prodrugs thereof, wherein Q1 is phenyl substituted by one or more halo; optionally substituted naphthyl, indolyl, benzothiophenyl, benzofuranyl, benzyl or fluorenyl; the dotted line represents an optional... | 03/18/1997 |
| 5554627 | Tachykinin antagonists Compounds of formula (I), wherein Q1 represents an aryl group; the dotted line represents an optional covalent bond; one of X and Y represents H and the other represents hydroxy or C1-6 alkoxy, or X and Y together form a group .dbd.O... | 09/10/1996 |
| 5552412 | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis Compounds of this formula ##STR1## are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.... | 09/03/1996 |
| 5510478 | 2-arylamidothiazole derivatives with CNS activity The compound of the formula: ##STR1## where R1, R2 and R3 are, independently, H, alkyl, halo, perhaloalkyl, hydroxy, alkoxy, aryl or arylalkyl; n is an integer from 0-5; R is azabicyclo 2.2.2!octyl or azabicyclo 2.2.1... | 04/23/1996 |
| 5457122 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, possess an antagonistic activity on leukotriene B4.... | 10/10/1995 |
| 5413997 | Triphenylmethane derivatives A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.... | 05/09/1995 |
| 5395832 | Benzamide derivatives A benzamide derivative represented by the following formula: ##STR1## wherein R1 represents a hydrogen atom or a lower alkanoyl group; R2 represents a hydrogen atom or a halogen atom; R3 represents a lower alkoxy grou... | 03/07/1995 |
| 5391549 | Cinnoline-3-carboxylic acid derivatives A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical formulations containing the same for the preve... | 02/21/1995 |
| 5324724 | Compounds for the treatment of senile dementia Azabicyclic compounds, processes for their preparation and their use in the treatment and/or prophylaxis of dementia in animals.... | 06/28/1994 |
| 5256671 | Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy Compounds of formula (I), and salts and prodrugs thereof: ##STR1## wherein Q is the residue of an optionally substituted azabicyclic ring system; the dotted line represents an optional double bond; X represents H, --OH, .dbd.O or halo; R1 repre... | 10/26/1993 |
| 5252570 | Amidino and guanidino derivatives New pharmacologically active amidino and guanidino derivatives which are 5-HT3 receptor antagonists useful as antiemetic, gastric prokinetic and antimigrainic agents of the following general formula (I) ##STR1## wherein the substituents ar... | 10/12/1993 |
| 5192799 | Coumaran group containing amine compounds and their acid addition salts and quaternary ammonium salts and the use thereof as anti arrhythmic agents and as psychotropic agents Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for t... | 03/09/1993 |
| 5102901 | New 3-N substituted carbamoyl-indole derivatives The invention relates to a group of new 3-N substituted carbamoyl-indole derivatives of the formula ##STR1## having an antagonistic activity on 5-HT receptors. The compounds can be used for the treatment of symptoms which are caused by excessive ... | 04/07/1992 |
| 5096901 | Pharmacologically active amides and esters containing an azabicycloalkane moiety Compounds of formula ##STR1## wherein R1 is hydrogen or one or more specified substituents, X is --O-- or --NR2 -- where R2 is lower alkyl, lower alkenyl, lower alkynyl, aryl or specified substituted lower alkyl or R2... | 03/17/1992 |
| 5066680 | Novel substituted-acetamide compound and a process for the preparation thereof Compounds of the formula ##STR1## wherein R1 is aryl which may have one or more suitable substituent(s), R2 is aryl which may have one or more suitable substituent(s), lower alkyl or cyclo(lower)alkyl, R3 is hydrogen,... | 11/19/1991 |
| 4983600 | Heterocyclic compounds useful as 5-HT3 antagonists Aroyl ureas and carbamic acid derivatives of formula A--CO--NHCW--Y--B and pharmaceutically acceptable salts thereof wherein A is a specified aromatic radical including optionally substituted phenyl W is O or S Y is NH or S and B is a specified saturated azacyclic ring,... | 01/08/1991 |
| 4959367 | 4-oxo-1,2,3-benzotriazines Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein X is N or CH; R1 and R2 are the same or different and are hydrogen, halogen, CF3, C1-6 alkyl, C1-7 acyl, C... | 09/25/1990 |
| 4735959 | Carboxylic acid amides and pharmaceutical compositions containing them There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula I... | 04/05/1988 |
| 4670456 | 4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropic agents and as agents for treating cerebral insufficiency The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl ... | 06/02/1987 |
| 4612319 | Bridged quinolizidinylbenzamides, compositions containing them and methods for their use A compound of formula (I), or a pharmaceutically acceptable salt, or N-oxide thereof, or a solvate of any of the foregoing: ##STR1## wherein p is 0 to 2; q is 0 to 3; j is 0 to 4; one of R5 and R6 is hydrogen, C1-6 alkyl, ... | 09/16/1986 |
| 4404138 | 3-[2-(Azabicyclo) ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones Anticholinergic 3-[2-(azabicyclo)ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin -5-ones useful for treating bronchospastic diseases in mammals are disclosed. Also disclosed are methods for preparing said compounds, pharmaceutical compositio... | 09/13/1983 |
| 4350691 | Certain azabicyclocarboxamides and compositions containing same Compounds of the formula (III) and pharmaceutically acceptable salts thereof: ##STR1## wherein: R1 is a C1-6 alkoxy or C1-6 alkylthio group; R2 and R3 are the same or different and are hydrogen, halog... | 09/21/1982 |
| 4336259 | Certain aza-bicyclo-benzamide derivatives and pharmaceutical compositions containing same Substituted benzamides having useful pharmacological properties, pharmaceutical compositions containing the same, pharmaceutically acceptable salts thereof, and procedure for administering said compositions. The active compounds have dopamine antagonist a... | 06/22/1982 |
| 4273778 | Pharmaceutically active aza-bicyclo-benzamide derivatives This invention relates to novel substituted benzamides having useful pharmacological properties, to pharmaceutical compositions containing them, and to a process for their preparation. N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide, 1-ethyl-2... | 06/16/1981 |
| 4261990 | N-alkyleneiminoalkyl-dicarboximides as antiallergics and antiasthmatics N-(diphenylmethoxy-mono- or bicyclic-alkyleneiminoalkyl)-dicarboximides, e.g. those of the formula ##STR1## A=aliphatic or cycloaliphatic radical R,R'=H, alkyl, halogen or CF3 R"=H or both are ethylene q=2-4 and salts thereof are antiallergics ... | 04/14/1981 |
| 4144271 | N-Substituted mercaptoacetamidines and their use N-substituted mercaptomethylacetamidines are prepared, and are useful as immunoregulants for correcting an imbalance of immune homeostasis, particularly, as immunostimulants in the treatment of autoimmune and immune deficient diseases and disorders.... | 03/13/1979 |
| 4134890 | 2-Aryl-2-[ω-(diis opropylamino)alkyl]-ω-(azabicycloalkyl)alkanamides Novel 2-aryl-2-[ω-(diisopropylamino)alkyl]-ω-(azabicycloalkyl)alkana mides are described herein. The present compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an app... | 01/16/1979 |
| 4086234 | Process for the preparation of tertiary amines Certain tertiary amines useful as pharmaceuticals are prepared in improved yields by condensing a cyclic secondary amine with a primary alkyl halide in an aqueous medium in the presence of an acid acceptor.... | 04/25/1978 |
| 4079141 | Azabicycloalkanes Novel substituted azabicycloalkanes and methods of preparing the same are disclosed. These compounds are useful as analgetic agents which exhibit a tendency towards low physical dependence.... | 03/14/1978 |
| 4076937 | Dibenzyl glycolic acid derivatives The present invention is concerned with new dibenzylglycolic acid derivatives and with the preparation thereof. These derivatives show an extraordinary anti-hypertensive and antisecretory profile.... | 02/28/1978 |
