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| Number | Title | Issue Date |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7285546 | Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents The present invention concerns a compound of formula (I) wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or arom... | 10/23/2007 |
| 7241887 | 3-azabicyclo[3.2.1]octane derivatives The subject invention relates to 3-azabicyclo[3.2.1]octane derivatives, pharmaceutical compositions comprising such derivatives and methods of using such derivatives to treat disease states, disorders and conditions mediated by opioid receptors. The subject inventio... | 07/10/2007 |
| 7169774 | Cephalotaxane derivatives and their processes of preparation and purification The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constit... | 01/30/2007 |
| 7166588 | Derivatives and analogs of galanthamine New compounds of general formula I ... | 01/23/2007 |
| 7060699 | Aryl and heteroaryl diazabicycloalkanes, their preparation and use The present invention relates to novel aryl and heteroaryl diazabicycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological pro... | 06/13/2006 |
| 6992078 | Plant extracts and alkaloids having antitussive activity The present invention provides plant extracts, isolated alkaloids, synthetic alkaloids and compositions having antitussive activity. In some preferred embodiments, the plant extracts and the isolated alkaloids are from a plant of a genus in the family Stemonaceae... | 01/31/2006 |
| 6887868 | Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I): wherein: R1, R2, R3, R4, R5, R6 R7, R8, n, m, and X have any of the value... | 05/03/2005 |
| 6797819 | Alkaloids The present invention provides novel alkaloid compounds and collections of these compounds, and provides methods for the synthesis of these compounds using biomimetic synthetic strategies. Additionally, the present invention provides pharmaceutical compositions and ... | 09/28/2004 |
| 6617452 | Process for the isolation of galanthamine The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; an... | 09/09/2003 |
| 6579869 | Cephalotaxanes: their method of preparation and their use in treatment of cancers, leukemias, parasites, including those resistant to usual chemotherapeutic agents, and as reversal agents The present invention concerns a compound of formula (I) ##STR1## wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarbon radical containing 1 to 30 carbon ... | 06/17/2003 |
| 6573376 | Process for the isolation of galanthamine The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; an... | 06/03/2003 |
| 6538003 | Pyridopyranoazepine derivatives, their preparation and their therapeutic application The invention relates to pyridopyranoazepine derivatives, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment or prevention of disorders associated with a dysfunction of the ni... | 03/25/2003 |
| 6468998 | Pyrrolidine compounds and medicinal utilization thereof The present invention provides a pyrrolidine compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically acceptable salt thereof. The present invention further pr... | 10/22/2002 |
| 6423842 | Muscarinic agonists and antagonists The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.... | 07/23/2002 |
| 6417365 | Method for recovering medicaments from preparations, and from the precursors or wastes thereof In a process for recovering medicinal substances or active substances from preparations, their initial products or waste, a flat-shaped starting material in the form of a film with adhesive and an active substance-containing material is provided with one ... | 07/09/2002 |
| 6407229 | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,... | 06/18/2002 |
| 6392038 | Process for preparing single enantiomer narwedine A process for the preparation of substantially single enantiomer (-)-narwedine comprises seeding a solution of racemic narwedine dissolved in a solvent with substantially single enantiomer (-)-narwedine, provided that if an added amine base is present the... | 05/21/2002 |
| 6387512 | Grey coloring photochromic fused pyrans A photochromic grey coloring 2H-naphtho[1,2-b]pyran of formula (1) wherein R1 is selected from mono-, di- or poly-substituted aryl groups, mono-, di- or poly-substituted naphthyl groups and mono-, di- or poly-substituted heteroaryl groups, wher... | 05/14/2002 |
| 6346618 | Optical resolution of narwedine-type compounds A process for the asymmetric transformation of a racemic compound of formula (I) wherein R1 is H or a alkyl group having up to 20 carbon atoms, R2 is H, or an alkyl, aryl, alkaryl or aralkyl group having up to 20 carbon atoms, and X ... | 02/12/2002 |
| 6323196 | Galanthamine derivatives as acetylcholinesterase inhibitors This application relates to compounds of the formula ##STR1## wherein R1 is hydrogen, (C1 -C12)alkylcarbonyl, (C1 -C12)alkoxycarbonyl, mono(C1 -C12)alkylaminocarbonyl, or di(C | 11/27/2001 |
| 6323195 | Galanthamine derivatives as acetylcholinesterase inhibitors This application relates to compounds of the formula ##STR1## wherein R1 is hydrogen, (C1 -C12 alkylcarbonyl, (C1 -C12)alkoxycarbonyl, mono(C1 -C12)alkylaminocarbonyl, or di(C | 11/27/2001 |
| 6323194 | Muscarinic agonists and antagonists The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.... | 11/27/2001 |
| 6319919 | Galanthamine derivatives for treatment of alzheimer's disease Compounds of the formula ##STR1## wherein the broken line represents an optionally present double bond, and R1 -R3, R4, R6 and R9 are as defined herein, and compositions containing these compounds can... | 11/20/2001 |
| 6316439 | Galanthamine derivatives as acetylcholinesterase inhibitors This application relates to compounds of the formula ##STR1## wherein R1 is hydrogen, (C1 -C12)alkylcarbonyl, (C1 -C12)alkoxycarbonyl, aryl(C1 -C12)alkylaminocarbonyl, mono(C | 11/13/2001 |
| 6184004 | Process for the preparation of galanthamine and its derivatives The subject invention pertains to a process for preparing a compound having a formula (4) or (5), in either optically-enriched or racemic form, wherein R1, R2, R3 and R4 are independently selected from hydrogen,... | 02/06/2001 |
| 6150354 | Compounds for the treatment of Alzheimer's disease A method of treating Alzheimer's disease and related dementias by treatment with analogs of galanthamine, particularly those wherein the methoxy and hydroxy substituents are replaced by, for example carbamate groups, the methoxy is replaced by hydroxy and... | 11/21/2000 |
| 6136968 | Homoazaadamantane spirooxazines and their use in the field of ophthalmic optics Described are novel reversible photochromic compounds of the homoazaadamantane spirooxazine family. Certain substituents are present on the nitrogen atom of the homoazaadamantane portion of the compound and on the benzene ring fused to the oxazine portion... | 10/24/2000 |
| 6093815 | Galanthamine derivatives and process for their preparation A process for preparing a compound having formula (11), comprises oxidative cyclization of a tertiary amine having formula (12), wherein X1 is a removable functionality, X2 is hydrogen or a group as defined above for X1, a... | 07/25/2000 |
| 6087495 | Process for the preparation of galanthamine The subject invention concerns a process for the preparation of enantiomerically-enriched galanthamine from racemic galanthamine, and a process for increasing the enantiomeric excess of enantiomerically-enriched galanthamine, by direct crystallization of ... | 07/11/2000 |
| 6043359 | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2]benzazepine The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,... | 03/28/2000 |
| 6017910 | PCP receptor ligands and the use thereof The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention of neuronal loss in ischemia, hypoxia, brain or spina... | 01/25/2000 |
| 5990104 | Polycyclic alcaloid-derivatives as NMDA-receptor antagonists Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH)--NH2, ... | 11/23/1999 |
| 5958903 | Galanthamine derivatives, and their pharmaceutical compositions Novel galanthamine derivatives of general fonnulae (Ia) and (Ib), a method for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as cholinesterase inhibitors, are disclosed. ##STR1##... | 09/28/1999 |
| 5912343 | Tertiary amines containing side-chain organolithium structures and method for the preparation thereof A compound comprising at least one cyclic amine, having an organolithium side-chain, defined according to formula (I) ##STR1## wherein Z is a lithium atom (Li); R1 is selected from the group consisting of organic groups containing from 1 t... | 06/15/1999 |
| 5869652 | Process for producing active substances from unused or discarded devices for the transdermal administration In a process for reprocessing devices for the transdermal application of active substances or their process waste, active substance-containing components are brought into solution and the active substances are recovered therefrom.... | 02/09/1999 |
| 5688789 | PCP receptor ligands and the use thereof The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzoa,d!cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention of neuronal loss in ischemia, hypoxia, brain or spin... | 11/18/1997 |
| 5599810 | Furo- and thieno[4,3,2-ef][3]benzazepines useful as alpha adrenergic receptor antagonists Alpha-adrenergic receptor antagonsists having the formula (I) as set forth below which are useful to produce alpha-adrenergic antagonism, pharmaceutical compositions thereof, and methods of treatment therewith are disclosed: ##STR1## The variabl... | 02/04/1997 |
| 5534633 | Aminoketone sensitizers for photopolymer compositions Aminoketone-substituted coumarin sensitizers having tethered tertiary amino groups are described which have extremely good photosensitivity. The sensitizers of the instant invention have the formula: ##STR1## wherein R1 and R2 e... | 07/09/1996 |
| 5508401 | Substituted dibenzo[a,d]cycloheptene NMDA antagonists This invention involves novel neuroprotectant agents of the formula: ##STR1## in which R1 and R3 are, independently, hydrogen, cyano, nitro, halo or perhaloalkyl, with the proviso that one of R1 and R3 is o... | 04/16/1996 |
