Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 7238685 | Benzo-fused heterocycles as endothelin antagonists The invention relates to novel benzo-fused heterocycles and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compos... | 07/03/2007 |
| 7176195 | Fused azepine derivatives and their use as antidiuretic agents Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9–11) are new. Compounds according to the invention are vasopressin V2 receptor agonists. Pharm... | 02/13/2007 |
| 7074921 | Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity. ... | 07/11/2006 |
| 6762178 | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and de... | 07/13/2004 |
| 6696435 | Substituted N,N-disubstituted fused-heterocyclo amino compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 02/24/2004 |
| 6544984 | 2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids Compounds having the following formula: ##STR1## are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss.... | 04/08/2003 |
| 6458783 | Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected by compounds of the formulas ##STR1## their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs and solvates thereof.... | 10/01/2002 |
| 6455519 | Use of substituted N, N-disubstituted fused-heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for t... | 09/24/2002 |
| 6369221 | Thiazolobenzoheterocycles, preparation and medicines containing same Disclosed are thiazolobenzoheterocycles of the general formula ##STR1## Including their isomers, racemates, enantioners and salts thereof, as well as processes for preparing these compounds and medicaments containing them. Also disclosed are novel interme... | 04/09/2002 |
| 6140322 | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase There are provided novel compounds of formula (I) ##STR1## wherein X, R1, R2, R3, R4 and R5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acce... | 10/31/2000 |
| 6121258 | 1,5-heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibito... | 09/19/2000 |
| 6008214 | Bicyclic compounds This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation and bone resorption, pharmaceutical compositions for effecting such activity, and a me... | 12/28/1999 |
| 5985869 | Benzoheterocyclic compounds Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R2 is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy,... | 11/16/1999 |
| 5942614 | Process to produce midazolam The present invention discloses new processes in the preparation of midazolam (VII), ##STR1## a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.... | 08/24/1999 |
| 5831089 | Process to produce midazolam The present invention discloses new processes in the preparation of midazolam (VII), ##STR1## a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.... | 11/03/1998 |
| 5747492 | Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by ampa receptors Compounds ##STR1## are useful for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof and methods for their use for treatment of subjects suffering from impaired nervous or intellectu... | 05/05/1998 |
| 5710242 | High temperature epoxy resins from hydrogenated quinoxalines A multi-functional epoxy resin with good high temperature properties allowing prolonged service at temperatures above 120° C. is derived from a precursor of formula (I): ##STR1## in which R3 to R8 inclusive are independently se... | 01/20/1998 |
| 5466799 | Synthesis of benzodiazepines A general method is provided for the synthesis of substituted 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepines by the reaction of bis-trifiated-2,5-dihydroxy benzophenones with 1,2-bisaminoethanes, followed by displacement of the 7-trifloxy group.... | 11/14/1995 |
| 5393760 | Guanidine derivatives Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The co... | 02/28/1995 |
| 5324726 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## wherein: R3 is ##STR2## --NH(CH2)2 --3 NHCOR7, ##STR3## or --X11 NR18 SO2 (CH2)q... | 06/28/1994 |
| 5317021 | 3-mercapto-glutamic acid derivatives Amino acid compounds of the formula: ##STR1## wherein the various symbols are as hereinafter described, which have inhibiting effect on enkephalinase.... | 05/31/1994 |
| 5175159 | 3-substituted-1,4-benzodiazepines as oxytocin antagonists Compounds of Formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarean delivery. ##STR1##... | 12/29/1992 |
| 5142048 | Intermediate for preparation of amino acid derivatives The invention relates to novel intermediate compounds for preparation of novel amino acid derivatives having renin inhibiting activity.... | 08/25/1992 |
| 4820834 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 04/11/1989 |
| 4724237 | 2-substituted-aminomethyl-1,4-benzodiazepines Novel 2-substituted-aminomethyl-1,4-benzodiazepines which have been found to be antagonists of the function of cholecystokinins (CCK), to the preparation of these compounds, and to the use of these compounds to antagonize the function of CCK, which antago... | 02/09/1988 |
| 4649137 | 2-acylaminomethyl-1,4-benzodiazepine compounds, the preparation thereof, and pharmaceutical compositions containing them New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I ##STR1## wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hy... | 03/10/1987 |
| 4595531 | Process of making benzodiazepine derivatives Benzodiazocines corresponding to the formula ##STR1## are converted to benzodiazepines corresponding to the formula ##STR2## of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment wh... | 06/17/1986 |
| 4594436 | Isomeric 2-chloromethyl-1,4-benzodiazepine or 3-chloro-1,5-benzodiazocine compound [1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I ##STR1## wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R1 is a hydrogen or halogen atom, lower alkyl radical, a... | 06/10/1986 |
| 4533662 | 2-Acylaminomethyl-1,4-benzodiazepine compounds and analgesic use Novel 2-acyl amino methyl-5-phenyl-1H-2,3-dihydro-1,4-benzo diazepine compounds of the following Formula I ##STR1## which have valuable pharmacological properties are provided. In said Formula I the acyl group --CO--R3 represents a benzoyl... | 08/06/1985 |
| 4508716 | [1,2]-Fused 1,4-benzodiazepine compounds, process for their preparation and compositions containing them [1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I ##STR1## wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R1 is a hydrogen or halogen atom, lower alkyl radical, a... | 04/02/1985 |
| 4505908 | 7-Bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepine pharmaceuticals Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I ##STR1## in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psy... | 03/19/1985 |
| 4497740 | 2-Azidomethyl-1,4-benzodiazepine compounds New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I ##STR1## wherein R1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R2 is a hy... | 02/05/1985 |
| 4401597 | Imidazodiazepines and processes therefor Novel immidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of ... | 08/30/1983 |
| 4390471 | Imidazodiazepines and processes therefor Novel Imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of o... | 06/28/1983 |
| 4382030 | 2-Acylaminomethyl-1,4-benzodiazepine derivatives and their salts, pharmaceutical compositions thereof and process for their preparation Novel 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine derivatives are disclosed which possess the Formula I ##STR1## wherein R1 represents hydrogen, lower alkyl, lower alkenyl or cyclopropylmethyl; R2 represents hydrogen, lo... | 05/03/1983 |
| 4371468 | Intermediates to produce imidazodiazepines Novel imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of o... | 02/01/1983 |
| 4368157 | Intermediates to produce imidazodiazepines Novel imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of o... | 01/11/1983 |
| 4368158 | Intermediates to produce imidazodiazepines Novel imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of o... | 01/11/1983 |
| 4368159 | Intermediates to produce imidazodiazepines Novel imidazobenzodiazepines and their analogs are useful as anticonvulsants, muscle relaxant, anxiolytic and sedative agents. Preferred compounds of this class belong to the imidazo[1,5-a][1,4]diazepine series which may have a very wide variety of o... | 01/11/1983 |
| 4349378 | Compounds useful as pesticides Sulphonanilides of formula ##STR1## and salts thereof, wherein R1 represents alkyl or certain other groups; R represents alkylene or alkenylene; A represents --COR12 or a carbonyl derivative or addition compound thereof, where R... | 09/14/1982 |
