Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7282496 | Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenera... | 10/16/2007 |
| 6878821 | Modifying chemoselectivity during oxidation of nitrogen compounds The invention concerns a method for chemoselective oxidation of an organic compound comprising several potentially oxidizable groups whereof at least one is a nitrogen group. Said method is characterised in that it consists in using at least a protic solvent, which ... | 04/12/2005 |
| 6858599 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 02/22/2005 |
| 6140322 | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase There are provided novel compounds of formula (I) ##STR1## wherein X, R1, R2, R3, R4 and R5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acce... | 10/31/2000 |
| 6121258 | 1,5-heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibito... | 09/19/2000 |
| 6071903 | 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids Compounds are provided having the following formula: ##STR1## wherein R, R1, R2, R3, and R4 are defined in the specification, which have matrix metalloproteinase inhibiting activity.... | 06/06/2000 |
| 5977101 | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as o... | 11/02/1999 |
| 5614543 | 1-(aryloxyalkyl)-3- (heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. D... | 03/25/1997 |
| 5580979 | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions The present invention makes available novel compounds represented by the general formula ##STR1## wherein Y represents a phosphate analog. Which compounds are useful for inhibiting an interaction between a protein containing an SH2 domain and a ... | 12/03/1996 |
| 5389631 | Fibrinogen receptor antagonists Fibrinogen receptor antagonists of the ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets wherein G is: ##STR2## for example, ##STR3##... | 02/14/1995 |
| 5175159 | 3-substituted-1,4-benzodiazepines as oxytocin antagonists Compounds of Formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarean delivery. ##STR1##... | 12/29/1992 |
| 5141735 | Substituted amino-benzodiazepines having anitviral activity Novel substituted 2-amino-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepines and compositions containing same for treatment and prophylaxis of viral infections, including HIV infections.... | 08/25/1992 |
| 5142048 | Intermediate for preparation of amino acid derivatives The invention relates to novel intermediate compounds for preparation of novel amino acid derivatives having renin inhibiting activity.... | 08/25/1992 |
| 4906630 | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.... | 03/06/1990 |
| 4877785 | Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents Non-peptidyl compounds characterized generally as ଲ-succinamidoacyl aminodios are useful as renin inhibitors for the treatment of hypertension.... | 10/31/1989 |
| 4859771 | Process for resolution and racemization of amines with acidic -hydrogens An economical, one-pot process for resolution-racemization of primary amines with -hydrogens via selective crystallization of diastereomeric chiral sulfonic acid salts and the subsequent in situ racemization of the other enantiomer by the catalytic... | 08/22/1989 |
| 4820834 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 04/11/1989 |
| 4785101 | Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses Benzodiazinone-pyridazinone and -hydroxypyrazolyl compounds possess cardiotonic activity and are included in therapeutic cardiotonic compositions useful in methods for increasing cardiac contractility and for the treatment of congestive heart failure.... | 11/15/1988 |
| 4755508 | Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin Benzodiazepines of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 07/05/1988 |
| 4208327 | 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds having the formula ##STR1## wherein A is methylene or carbonyl; Z is oxygen, imino or thio; R1, R2, and R3 independently are hydrogen, halogen, t... | 06/17/1980 |
| 4102881 | Benzodiazepine derivatives Compounds of the formula ##STR1## wherein R2 is lower alkyl and each of rings A and B is unsubstituted or substituted by a member selected from the group consisting of nitro, trifluoromethyl, halogen, alkyl and alkoxy, and processes for th... | 07/25/1978 |
| 4094870 | 2-Substituted thio-1,4-benzodiazepine derivatives 2-substituted thio-1,4-benzodiazepine derivatives having medicinal use of the general formula ##STR1## wherein R1 and R2 individually signify hydrogen atom or a halogen atom, or a nitro, amino, hydroxy, cyano, alkyl, haloalkyl, ... | 06/13/1978 |
| 4060608 | Substituted hydroxymethyl benzodiazepines Novel 2-disubstituted amino 3H-1,4-benzodiazepines and their 4-oxides, acid addition salts thereof and a method for their preparation from 2-monosubstituted amino benzodiazepines and their 4-oxides.... | 11/29/1977 |
| 4056525 | 2,3-Dialkoxy-3H-1,4-benzodiazepines 2,3-Dialkoxy-3H-1,4-benzodiazepines which have CNS depressant activity.... | 11/01/1977 |
| 4008223 | 6-Aza-3H-1,4-benzodiazepines There are produced 6-aza-3H-1, 4-benzodiazepines and 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula ##STR1## where R1 is a halogen, R2 and R3 are hydrogen, halogen, trifluoromethyl, nitro, nitrile, hydroxy, l... | 02/15/1977 |
| 3972873 | Certain pyrido[3,2-e]1,4-diazepinones and derivatives There are prepared compounds of the formula: ##SPC1## Wherein: n is an integer from 1 to 4; R1 is alkyl of 1 to 6 carbon atoms, a hydroxy group, an amino group, an alkoxy group having 1 to 6 carbon atoms, a phenyl group or a phenyl group substi... | 08/03/1976 |
| 3941775 | 6-Aza-3H-1,4-benzodiazepines There are produced 6-aza-3H-1,4-benzodiazepines and 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula: ##SPC1## Wherein R1 is the group --NRa Rb, --NRa Rb Rc or --NRa acyl ... | 03/02/1976 |
