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| Number | Title | Issue Date |
| 7329653 | Cyclohexylphenyl vasopressin agonists The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl; “Z” represents optionally substituted phenyl or a 6-membered aromatic rin... | 02/12/2008 |
| 7317005 | Tricyclic benzodiazepines as vasopressin receptor antagonists The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the prese... | 01/08/2008 |
| 7223752 | Biphenyl vasopressin agonists A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1–C6) lower alkyl, | 05/29/2007 |
| 7005430 | Fused purine derivatives A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a sub... | 02/28/2006 |
| 6953791 | Dipeptide derivatives This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which inc... | 10/11/2005 |
| 6943171 | Polycyclic guanine derivative phosphodiesterase V inhibitors A compound having the formula (Ia) or (b), salt or solvate thereof, with the variables as defined herein, which can inhibit selectively phosphodiesterase V and can be useful for treating sexual dysfunction and other physiological disorders, symptoms and diseases: | 09/13/2005 |
| 6936604 | Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists The invention is directed to bridged bicyclic amino acid-derived [1,4]benzodiazepine compounds, intermediates and pharmaceutical compositions thereof useful as vasopressin receptor antagonists and methods for treating vasopressin mediated disorders. ... | 08/30/2005 |
| 6713475 | Tricyclic benzodiazepines as vasopressin receptor antagonists The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the prese... | 03/30/2004 |
| 6608193 | Methods for synthesis of amino-tetrahydroisoquinoline ring compounds Methods of preparing amino-substituted-tetrahydroisoquinoline ring compounds include the steps of providing a support-bound amino-substituted-tetrahydroisoquinoline compound; forming an intermediate by reacting the support-bound amino-substituted-tetrahyd... | 08/19/2003 |
| 6569851 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits ଲ-amylo... | 05/27/2003 |
| 6306847 | Condensed purine derivatives The present invention provides condensed purine derivatives or pharmacologically acceptable salts thereof exhibiting adenosine A3 acceptor antagonising activity, and having an antiasthmatic action, a bronchodilator action, an antiantiitching ac... | 10/23/2001 |
| 6140322 | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase There are provided novel compounds of formula (I) ##STR1## wherein X, R1, R2, R3, R4 and R5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acce... | 10/31/2000 |
| 5985871 | Benzoxazine compounds for enhancing synaptic response Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for preparing such compounds, and methods for their use in treat... | 11/16/1999 |
| 5977101 | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as o... | 11/02/1999 |
| 5846969 | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives A sulfonamide derivative or a sulfonic ester derivative represented by the following general formula (I): ##STR1## {G represents an aromatic 5- or 6-membered ring; L represents O or --N(R1)-- (R1 represents hydrogen or lower alk... | 12/08/1998 |
| 5834464 | Imidazolinobenzodiazepines Imidazolinobenzodiazepines are cholecystokinin B (CCK-B) antagonists useful as anxiolytic agents. The compounds have structures such as: ##STR1##... | 11/10/1998 |
| 5786352 | Cyclic compounds, their production and use Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C | 07/28/1998 |
| 5679672 | Benzodiazepines Compounds of structures (I) and (Ia) are Class III antiarrhythmic agents ##STR1##... | 10/21/1997 |
| 5461048 | Tricyclic compounds having cholecystokinin antagonist activity The invention relates to novel cholecystokinin antagonists of the formula ##STR1## wherein R1 is aryl or substituted aryl, and a pharmaceutically acceptable salt thereof useful as cholecystokinin antagonists.... | 10/24/1995 |
| 5268372 | 2,5-benzodiazocine antiarrhythmic agents Novel 2,5-benzodiazocines of formulas II and IV, pharmaceutical compositions containing them, processes for preparing them and methods of treating cardiac arrhythmias in mammals utilizing them. ##STR1##... | 12/07/1993 |
| 5237060 | Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids The invention relates to a process for the preparation of highly antibacterially active enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids and derivatives of the formula (I) ##STR1## in which 1) a compound of the formula ##STR2## ... | 08/17/1993 |
| 5104868 | Tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and esters This invention relates to novel tricyclic derivatives of 7-substituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acids and certain esters and cation salts thereof. The compounds of this invention are substituted at the 7-position by vinyl, W--CH.dbd.C... | 04/14/1992 |
| 5070086 | Imidazo- and pyrimido-quinoline, naphthyridine and pyridopyrazine compounds Imidazo- and pyrimido-quinoline, naphthyridine and pyridopyrazine compounds, methods of making said compounds and their use as anti-allergy, antiinflammatory and/or agents for the treatment of hyperproliferative skin disease are disclosed.... | 12/03/1991 |
| 5008263 | Diazepine antiallergy agents Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or isothiazole, X is O, S or NH Y is 1,4 phenylene or a group o... | 04/16/1991 |
| 4978753 | 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones A 7-phenylpyrimido[1,2-a][1,4]benzodiazepin-3(5H)-ones of the formula II: ##STR1## wherein Ro is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, --COOR in which R is alkyl defined as above, ##S... | 12/18/1990 |
| 4871844 | Diazepihium dyes Novel diazepinium compounds having the structural formula: ##STR1## wherein R2 and R4 are individually alkyl of 3 to 7 carbon atoms R5, R6 and R7 are individually H or alkyl; and X.crclbar. is an... | 10/03/1989 |
| 4735941 | 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents Aromatic 1,4-benxodiazepines with fused 5- or 6-membered heterocyclic rings which are antagonists of cholecystokinins and/or gastrin, and are useful in the treatment or prevention of CCK-related and/or gastrin-related disorders of the gastrointestinal, ce... | 04/05/1988 |
| 4725596 | Pyrimidine derivatives having anti-allergy, anti-inflammatory and immuno suppressant activity Certain pyrimidine derivatives are useful in treating allergic, inflammatory and hyperproliferative skin diseases and in suppressing the immune response. Methods for preparing the compounds and methods for their use are also described.... | 02/16/1988 |
| 4678499 | Herbicidal sulfonamides Benzenesulfonamide compounds such as N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl-4 -oxo-1-phenyl-indeno[1,2-C]-pyrazole-5-sulfonamide and N-[(4-methoxy-6-methyl-pyrimidin-2-yl)aminocarbonyl]-1,4-dihydro-3-methyl- 4-oxo-1-ph... | 07/07/1987 |
| 4545935 | Amidoalkylation reactions of anilines Benzodiazepines having associated carbonyl lactam ring structure are synthesized from N-2-bromoethyl-5-alkoxy-2-pyrrolidinone and analine compounds, in the first ever such direct single step synthesis. The produced compounds are known biological active co... | 10/08/1985 |
| 4508716 | [1,2]-Fused 1,4-benzodiazepine compounds, process for their preparation and compositions containing them [1,2]-fused 1,4-benzodiazepine compounds are disclosed corresponding to the general formula I ##STR1## wherein X is an oxygen or sulfur atom or an optionally substituted imino group, R1 is a hydrogen or halogen atom, lower alkyl radical, a... | 04/02/1985 |
| 4489078 | Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally act... | 12/18/1984 |
| 4404380 | Triazolopyrimidines Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally act... | 09/13/1983 |
| 4338314 | [1,2]Anellated-7-phenyl-1,4-benzodiazepine and pharmaceutical compositions thereof and use for treatment of ulcers Compounds of [1,2]anellated-7-phenyl-1,4-benzodiazepines having the formula I ##STR1## wherein X is oxygen, sulfur or NR; R is H, C1 -C5 alkyl, C1 -C5 alkyl, substituted with a terminal phenyl group, which is ... | 07/06/1982 |
| 4250095 | Imidazobenzodiazepines A multistep process is presented for the preparation of imidazobenzodiazepines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, Y is selected from the group consisting of hy... | 02/10/1981 |
| 4226771 | 1,2,5-Oxadiazino[5,4-a][1,4]benzodiazepine derivatives A multistep process is presented for the preparation of imidazobenzodiazepines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, Y is selected from the group consisting of hydroge... | 10/07/1980 |
| 4213983 | Treating gastro-intestinal disorders and emesis with n-(heterocyclic substituted) benzamides Compounds of the formula (I), and their pharmaceutically acceptable salts: ##STR1## wherein: R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen, halogen, CF3, hydroxy, C | 07/22/1980 |
| 4175079 | Benzodiazepine derivatives The present invention relates to pyrimidobenzodiazepine derivatives of the formula (I) and 2-(N-acetoacetal)aminobenzodiazepine derivatives of the formula (II), which compounds have the following formulas: ##STR1## wherein R1 represents a ... | 11/20/1979 |
| 4120965 | Octahydro-1,4-diazepino[1,7-b]isoquinolines This invention provides new compounds of formula I, ##STR1## wherein R1 is hydrogen or alkyl of 1 to 5 carbon atoms, R2 is a group ##STR2## wherein N IS A WHOLE NUMBER FROM 0 TO 3, R5 and R6, independently,... | 10/17/1978 |
| 4086230 | 1,5-Dihydro-7-aryl-as-triazine[4,3,-][1,4]benzodiazepin-1-ols Compounds of the formula: ##STR1## wherein R1 is alkyl of 1 to 3 carbon atoms, inclusive; wherein R2 is hydrogen, methyl or ethyl; wherein R3 is hydrogen, fluoro, chloro, bromo, nitro and -CF3 ; and wherein... | 04/25/1978 |
