Class 540/556 - Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc.)

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein (a) at least three members of one cyclo
No. of patents: 122
Last issue date: 10/28/2008

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Number	Title	Issue Date
7442694	Diazabicyclic compounds useful in the treatment of CNS and other disorders The present invention relates to a compounds of formula I: wherein A, B, D, E and F are defined herein; that are useful in treating central nervous system (CNS) diseases, disorders and conditions, such as but not limited to...	10/28/2008
7439236	Pharmaceutical composition for the treatment of CNS and other disorders The present invention relates to compounds of formula I The substituent designations are as disclosed. At least one of B, Q, D and E is nitrogen. The present invention also provides a method of treating disorders of the Centr...	10/21/2008
7358243	Diazabicyclonane and-decane derivatives and their use as opioid receptor ligands This invention relates to novel diazabicyclononane and -decane derivatives useful as opioid receptor ligands. More specifically, the invention provides compounds useful as μ opioid receptor ligands. ...	04/15/2008
7351839	Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives This invention provides processes for preparing compounds formula: wherein R is H, alkyl, acyl, aryl, aroyl or —C(O)R′; R′ is alkyl or aryl; R1, R2, R4 and R5 are H, —OH, ...	04/01/2008
7288648	High temperature crystallization of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane A method of crystallizing an epsilon-polymorph of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane (CL-20). The method comprises combining the CL-20, at least one organic solvent, and at least one nonsolvent to ...	10/30/2007
7279572	Process for the 2-stage synthesis of hexanitrohexaazaisowurtzitane starting from a primary amine A subject-matter of the present invention is a novel process for the synthesis of hexanitrohexaazaisowurtzitane (HNIW), a compound of use as energetic filler in powders, propellants and explosives. This process comprises a first stage of reaction of an α,β-...	10/09/2007
7271163	Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of the formulae: wherein: R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms; R2 and R	09/18/2007
7271162	Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of formula I having the structure wherein: R1 and R2 are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —S...	09/18/2007
7271164	Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives This invention provides compounds of the formula: wherein R1 and R2 are each, independently, H, alkyl, cycloalkyl, —CH2-cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, �...	09/18/2007
RE39743	2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use Novel compounds of the formula wherein the substituents are defined as in the application having antibiotic properties. ...	07/24/2007
RE39680	Substituted heterocycle fused gamma-carbolines The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6a, R6b, R7	06/05/2007
7223753	Diazabicyclic biaryl derivatives This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the...	05/29/2007
7220741	1,4-diazabicycloalkane derivatives, their preparation and use This invention relates to novel 1,4-diazabicycloalkane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the mono...	05/22/2007
7220740	1,4-diazabicyclo[3.2.2]nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof Compound corresponding to the general formula (I) in which X represents an oxygen or sulphur atom or an NH group and R1, R2, R3 and R4 each represent a hydrogen or halo...	05/22/2007
7141563	Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives This invention provides processes for preparing compounds formula: wherein R is H, alkyl, acyl, aryl, aroyl or —C(O)R′; R′ is alkyl or aryl; R1, R2, R4 and R5 are...	11/28/2006
7129348	Polycyclic, polyamides as precursors for energetic polycyclic polynitramine oxidizers Hexabenzylhexaazaisowurtzitane is converted to tetracetyl, dibenzyl azaisowurtzitane. The benzyl groups are removed by catalytic transfer hydrogenolysis leaving a pair of available nitrogens. The available nitrogens are acetylated, and the resulting intermediate is ...	10/31/2006
7129237	[1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents Compounds of Formula I or a pharmaceutically acceptable salt thereof are provided: where R1 through R7 are defined herein. The compounds of Formula I are 5HT2c agonists or partial agonists, ...	10/31/2006
7119180	2-halogenated derivatives of 5-O-desosaminyl-erythronolide A, their preparation process and their antibiotic use A subject of the invention is a process for the preparation of the compounds of formula (I): Wherein the substituents are defined as in the application. The compounds of this invention exhibit antibiotic properti...	10/10/2006
7119087	4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof Compound corresponding to the general formula (I) in which R2 represents a chlorine atom, a methyl group or a 3-thienyl group. Therapeutic application. ...	10/10/2006
7091198	2,5-disubstituted pyrimidine derivatives The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for producing medicaments, in particular medicaments for the treatment of cent...	08/15/2006
7071185	1,2,3,4,7,8-hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents Compounds of Formula I or a pharmaceutically acceptable salt thereof are provided: where R1 through R7 are defined herein. The compounds of Formula I are 5HT2c agonists or partial ago...	07/04/2006
7060699	Aryl and heteroaryl diazabicycloalkanes, their preparation and use The present invention relates to novel aryl and heteroaryl diazabicycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological pro...	06/13/2006
7022697	4-(Oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]-nonane derivatives, preparation and therapeutic use thereof The invention relates to compounds of the Formula I, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment or prevention of disorders linked to a dysfunction of the nicotinic receptors. ...	04/04/2006
7015212	Thiazepine inhibitors of HIV-1 integrase The present invention discloses non-catechol compounds, such as thiazolothiazepines, and analogs and derivatives thereof, which are anti-integrase inhibitors. The compounds, which are useful as treatments for HIV disease, include compounds (I), (II), (III), or pharm...	03/21/2006
7001902	4-(2 phenylthiazol-5-yl)-1, 4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof Compound corresponding to the general formula (I) in which R1, R2, R3, R4 and R5 each represent a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifl...	02/21/2006
6998399	4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof The invention relates to compounds of the Formula I, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment or prevention of disorders associated with a dysfunction of the nicotinic receptors. ...	02/14/2006
6992185	Crystallization of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane A method is provided in which 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.05,903,11]-dodecane (CL-20 or HNIW) is crystallized to its ε-polymorph by an inverse precipitation technique. A dry CL-20 solvent solution containing a...	01/31/2006
6987106	1,4-diazabicyclo[3.2.2]nonane-4-carboxylates and carboxamide derivates, production and use thereof in therapeutics Compounds of general formula in which X represents an oxygen atom or a group of formula NZ in which Z represents a hydrogen atom or an alkyl group, n represents a number 0, 1 or 2, and R1, R2, R	01/17/2006
6936604	Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists The invention is directed to bridged bicyclic amino acid-derived [1,4]benzodiazepine compounds, intermediates and pharmaceutical compositions thereof useful as vasopressin receptor antagonists and methods for treating vasopressin mediated disorders. ...	08/30/2005
6916922	Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives This invention provides a process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino[6,7,1-hi]indole derivatives of the general formula: wherein: R is H, alkyl, cycloalkyl, —CH...	07/12/2005
6887868	Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I): wherein: R1, R2, R3, R4, R5, R6 R7, R8, n, m, and X have any of the value...	05/03/2005
6881734	Pharmaceutical composition for the treatment of CNS and other disorders The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical c...	04/19/2005
6858604	Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of the formula: wherein R1 and R2 are each, independently, H, alkyl, cycloalkyl, —CH2-cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—...	02/22/2005
6849619	Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, ...	02/01/2005
6844337	1,4-diazabicyclo[3.2.2]nonane-phenylisoxazole derivatives, their preparation and their application in therapeutics Compounds corresponding to general formula (I) in which R1, R2, R3, R4 and R5 each represent, independently of one another, a hydrogen or halogen atom or a nitro, ...	01/18/2005
6835730	4-heteroparyl-1,4-diazabicyclo[3.2.2]nonane, preparation and therapeutic use thereof Compounds of the general formula (I) in which R1, R2, R3 and R4 each represent a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, cyano, hydroxyl, alkyl or alkoxy...	12/28/2004
6809094	Pharmaceutical composition for the treatment of CNS and other disorders The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical c...	10/26/2004
6784172	Processes for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides processes for synthesizing compounds of formula I: wherein R is H or alkyl; R1, R2 are H, alkyl, alkoxy, halogen, fluorinated alkyl, —CN, alkyl sulfonamide, alkyl amide, am...	08/31/2004
6777407	Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of the formulae: wherein: R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms; R2 and R3 are each, independently, hydrogen, ...	08/17/2004
6777406	Substituted pyrroloquinolines and pyridoquinolines as serotinin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein is R1, R6a, R6b, R7	08/17/2004

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Class 540/556 - Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc.)