Class 540/551 - Nitrogen bonded directly to ring carbon of the hetero ring

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which nitrogen is bonded directly to a ring
No. of patents: 36
Last issue date: 03/08/2011

Number	Title	Issue Date
7902355	Process for the preparation of an 11-(4-substituted-1-piperazinyl)dibenzo[][1,4]thiazepine derivative A process for the preparation of an 11-(4-substituted-1-piperazinyl)dibenzo[b,f][1,4]thiazepine derivative, of general Formula (I), where A is hydrogen or a —(CH2)2—OH group or a —(CH2)2-0-(CH2)2	03/08/2011
7863441	Preparation of quetiapine The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure of a compound of the formula shown below, as well as novel intermediates in the process. ...	01/04/2011
7858777	Preparation method for quetiapine The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure and deprotection of a compound of the formula (I), as well as novel intermediates in the process. ...	12/28/2010
7847094	Industrial preparation of 11-[4-{2-(2-hydroxyethoxy) ethyl}-1-piperazinyl] dibenzo [b,f]-[1,4]thiazepine Disclosed herein is an industrial preparation of Quetiapine by the reaction of 11-piperazinyldibenzo[b,f][1,4]-thiazepine or its salt with 2-(2-chloroethoxy)ethanol in presence of an organic or inorganic base under neat or aqueous condition to form 11-[4-{2-(2-hydro...	12/07/2010
7807828	Olanzapine analogs and methods of use thereof The invention relates to novel compounds and methods of using them for modulating sleep. ...	10/05/2010
7807827	Procedure for preparing 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazineyl)-dibenzo[b,f] [1,4]thiazepine The invention relates to a procedure for preparing quetiapine by reaction between a compound of formula (II) and a compound of formula (III), in which X means a leaving group and P a protective group of alcohols resistant to alkaline conditions, in the presence of a...	10/05/2010
7687622	Process for preparing quetiapine fumarate Provided is a novel synthesis of quetiapine, and pharmaceutically acceptable salts thereof, in which an alkali metal halide or siliyl halide is included in the reaction mixture. ...	03/30/2010
7678902	Process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)dibenzo[b,f][1,4]thiazepine Disclosed is a process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine. In the process, low-priced 2,2′-dithiosalicylic acid as starting material is subjected to bond formation reaction with 1-chloro-2-nitrobenzen...	03/16/2010
7488821	Polymorph of Quetiapine fumarate and a process for its preparation The present invention relates to a novel polymorph of Quetiapine fumarate and a simple method for its preparation. ...	02/10/2009
7355042	Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio...	04/08/2008
7238686	Polymorphs of quetiapine fumarate The present invention relates to novel polymorphic forms of quetiapine fumarate, processes for their preparation and pharmaceutical compositions containing them. ...	07/03/2007
7071331	Synthesis of quetiapine and pharmaceutically acceptable salts thereof Provided is a novel synthesis of quetiapine employing phase transfer catalyst. ...	07/04/2006
6890919	Atypical antipsychotic agents having low affinity for the D2 receptor The present invention provides novel compounds of Formula I: The invention further relates to pharmaceutical compositions comprising compounds of Formula I and to methods of using compounds of Formula I to treat neurop...	05/10/2005
6391870	Pyrrolo [2,1-b][1,3]benzothiazepines with atypical antipsychotic activity Polycondensated heterocycles with a pyrrole[2,1-b][1,3]benzothiazepine structure of the following formula (I) ##STR1## where the groups are defined as in the description are disclosed. As compared to known antipsychotic agents, these compounds present ...	05/21/2002
6372734	Crystalline dibenzothiazepine derivative and its use as an antipsychotic agent ##STR1## Crystalline 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepin e (I) may be prepared by crystallizing 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepin e from a non-aromatic solvent such as ethy...	04/16/2002
6277831	1,4-benzothiazepine-1,1-dioxide derivatives substituted by sugar residues, process for their preparation, pharmaceuticals comprising these compounds, and their use The invention relates to substituted 1,4-benzothiazepine-1,1-dioxide derivatives and their acid addition salts. 1,4-Benzothiazepine-1,1-dioxide derivatives of formula 1, ##STR1## wherein R1, R2, R3, and Z have the meanings indi...	08/21/2001
6214820	Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci...	04/10/2001
6130217	Compounds enhancing antitumor activity of other cytotoxic agents This invention relates to certain heterocyclic compounds and their pharmaceutically acceptable salts, which are useful for sensitizing multidrug-resistant tumor cells to anticancer agents and multidrug resistant forms of malaria, tuberculosis, leishmania ...	10/10/2000
6121256	Compounds activating pharmacological effect of retinoids A compound represented by the formula (I) or (II) or a salt thereof wherein R' represents hydrogen atom or a C1-6 alkyl group; R2 and R3 independently represent a hydrogen atom or a C1-6 alkyl group, or R2	09/19/2000
5703072	Bicyclic nonane and decane compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, substituted or unsubstituted, unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from...	12/30/1997
5602121	Alkyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select...	02/11/1997
5602120	Benzyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select...	02/11/1997
5576314	Bicyclic nonane and decane compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select...	11/19/1996
5561127	Muscarinic receptor ligands Described herein are D4 receptor-selective compounds of the general formula I: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is sele...	10/01/1996
5538965	Dopamine receptor ligands Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select...	07/23/1996
5393752	Methylpiperazinoazepine compounds, preparation and use thereof Methylpiperazinoazepine derivatives corresponding to formula (I): ##STR1## wherein the symbols X, R1, R2, N1 and N2 have different meanings and pharmaceutically acceptable salts thereof, preparation and use...	02/28/1995
5344828	Piperazinealkanoic acid and a pharmaceutical composition comprising the same Novel polycyclic compounds represented by the following formula: A--(CH2)n --COOR1, wherein R1 represents a hydrogen atom or a lower alkyl group; n represents an integer of from 0 to 5; and A is a group represen...	09/06/1994
5317101	Tricyclic heterocycles The invention relates to tricyclic heterocycles of the formula I ##STR1## wherein X is oxy, thio, sulphinyl, sulphonyl, amino, (1-4C)alkylamino or methylene; Y is carbonyl or methylene; each R1 includes hydrogen, halogeno and various other subs...	05/31/1994
5106844	Imidazo[2,2-b][3]benzazepine and pyrimido[2,1-b][3]benzazepine antiarrhythmic agents Novel imidazo[2,1-b][3]benzazepines and pyrimido[2,1-b][3]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmia in mammals utilizing them, and processes for synthesizing them. ##STR1##...	04/21/1992
5098901	Imidazo [1,2-b][2]benzazepine and pyrimido [1,2-b][2]benzazepine antiarrhythmic agents Novel imidazo[1,2-b][2]benzazepines and pyrimido[1,2-b][2]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmias in mammals utilizing them, and processes for synthesizing them. ##STR1##...	03/24/1992
5036067	Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, ...	07/30/1991
4879288	Novel dibenzothiazepine antipsychotic 11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4 ]thiazepine is disclosed as a neuroleptic with a much reduced incidence of side effects such as acute dystonia and dyskinesia and tardive diskinesia....	11/07/1989
4794110	5-Aryl-11-substituted-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepined as analgesic and hypotensive agents There are disclosed compounds of the formula, ##STR1## where X and Y are each independently hydrogen, loweralkyl, halogen or trifluoromethyl; Z is hydrogen or 2- or 3-Cl, Br, I, CHO or CH.dbd.CR1 R2 where R1 and R	12/27/1988
4263207	10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof Novel dibenzo[b,f][1,4]thiazepine derivatives are employed in the treatment and control of allergic conditions such as allergic asthma....	04/21/1981
4224321	Biologically active tetracyclic compounds and pharmaceutical compositions containing same Novel and biologically active tetracyclic compounds are disclosed of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof, wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, C	09/23/1980
3962248	Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines This invention concerns a novel process for the preparation of 6-piperazinyl derivatives of morphantridine and corresponding ring-substituted and hereto analogues thereof, comprising reacting a compound of the formula: ##SPC1## Wherein A is benzene o...	06/08/1976

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Class 540/551 - Nitrogen bonded directly to ring carbon of the hetero ring