Quotables
"The Americans have need of the telephone, but we do not. We have plenty of messenger boys."
Sir William Preece, chief engineer, British Post Office ; 1878
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7407949 | Benzamide derivatives as oxytocin agonists and vasopressin antagonists Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds ... | 08/05/2008 |
| 7355042 | Treatment of CNS disorders using CNS target modulators The invention is directed to compositions and methods useful for treating Central Nervous System (CNS) disorders. Furthermore, the invention provides compositions and methods of treating sleep disorders. More specifically, the invention is directed to the compositio... | 04/08/2008 |
| 7320973 | Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal ... | 01/22/2008 |
| 7271196 | CETP activity inhibitors The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight cha... | 09/18/2007 |
| 7220736 | Pyrimidine compounds A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR4—, —S—, —O—, —CH═N—,... | 05/22/2007 |
| 7179909 | Process for the manufacture of a product of the thiazolo [3,4,5-de] [4,1]benzothiazepine type Novel processes for the preparation of a compound of the thiazolo[3,4,5-de] [4,1]benzothiazepine type and in particular of 2-imino-9-trifluoromethyl-4,5-dihydro-2H,7H-thiazolo[3,4,5-de] [4,1]benzothiazepine 6,6-dioxide methanesulfonate and (R,S)-2-imino-9-trifluorom... | 02/20/2007 |
| 7105663 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one Compounds of general formula (I) wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; R5 represents a hydrogen atom or a C1-3 alkyl, C2-3 alkenyl or C2-3... | 09/12/2006 |
| 6989379 | Selective NPY (Y5) antagonists This invention is directed to triazine derivatives, bicyclic compounds and tricyclic compounds which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of... | 01/24/2006 |
| 6916925 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds arc useful, inter alia, for determining the binding and/or receptor sites of the molecules. ... | 07/12/2005 |
| 6887838 | Bleach boosting components, compositions and laundry methods Formulation components such as bleach boosting compounds selected from the group consisting of bleach boosters comprising quaternary imine cations, zwitterions, polyions having a net charge of from about +3 to about 3 and mixtures thereof, bleaching species comprisi... | 05/03/2005 |
| 6806267 | Apoptosis-inducing compounds The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents. ... | 10/19/2004 |
| 6673781 | Tricyclic compounds having sPLA2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): ##STR1## wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocycl... | 01/06/2004 |
| 6620807 | Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists The present invention provides benzoheterocyclic carboxyamides, particularly pyridobenzodiazepine and pyridobenzoxazepine carboxyamides, of the general formula: ##STR1## wherein: W is O or NH, optionally substituted, as well as methods and pharmaceut... | 09/16/2003 |
| 6544979 | Fused imidazole derivatives for improving oral bioavailability of pharmaceutical agents This invention concerns the use of compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein the dotted line is an optional bond; n is 1 or 2; R1 is ... | 04/08/2003 |
| 6537987 | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, anti-Alzheimer's agents or anti-acne agents.... | 03/25/2003 |
| 6521769 | Chiral phosphines, transition metal complexes thereof and uses thereof in asymmetric reactions Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include chiral C1-C6 TunaPhos ligands. The ruthenium TunaPhos complex reduces ketones to the corresponding alcohols... | 02/18/2003 |
| 6369221 | Thiazolobenzoheterocycles, preparation and medicines containing same Disclosed are thiazolobenzoheterocycles of the general formula ##STR1## Including their isomers, racemates, enantioners and salts thereof, as well as processes for preparing these compounds and medicaments containing them. Also disclosed are novel interme... | 04/09/2002 |
| 6251894 | 1-(1,2-disubstituted piperidinyl)-4 (fused imidazole)-piperidine derivatives This invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; .dbd.Q ... | 06/26/2001 |
| 6218381 | Fused imidazole derivatives as multidrug resistance modulators This invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein the dotted line is an optional bond; n is 1 or 2; R1 is hydroge... | 04/17/2001 |
| 6090803 | Tricyclic vasopressin agonists The present invention provides compounds of the general formula: ##STR1## wherein W is O or NH, optionally substituted, as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied o... | 07/18/2000 |
| 5985871 | Benzoxazine compounds for enhancing synaptic response Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for preparing such compounds, and methods for their use in treat... | 11/16/1999 |
| 5965553 | Squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, Alzheimer's agents or anti-acne agents.... | 10/12/1999 |
| 5942506 | 1-2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives This invention relates to new 1-2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said benzodiazepine derivatives for the treatment of dise... | 08/24/1999 |
| 5846969 | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives A sulfonamide derivative or a sulfonic ester derivative represented by the following general formula (I): ##STR1## {G represents an aromatic 5- or 6-membered ring; L represents O or --N(R1)-- (R1 represents hydrogen or lower alk... | 12/08/1998 |
| 5817808 | Process for preparing benzodiazepine derivatives The object of the present invention is to provide an improved process for preparing benzodiazepine-3-alkyl carboxylate of formula(I) and its pharmaceutically acceptable salts and esters. ##STR1## wherein R1 is methyl, ethyl or isopropyl; R... | 10/06/1998 |
| 5770594 | Naphthyl-benzoxazepines or -benzothiazepines as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents and antiatheroscierosis agents.... | 06/23/1998 |
| 5753649 | Therapeutic agent for osteoporosis and diazepine compound A therapeutic agent for osteoporosis, comprising an azepine compound of the formula ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof as an active ingredient, a method for treating ost... | 05/19/1998 |
| 5686445 | Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treati... | 11/11/1997 |
| 5622950 | Pyrrolo-pyridine derivatives A class of pyrrolo[2,3-b]pyridine derivatives, substituted at the 3-position by a substituted piperazinylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor sub... | 04/22/1997 |
| 5593988 | Therapeutic agent for osteoporosis and diazepine compound A therapeutic agent for osteoporosis, comprising an azepine compound of the formula ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof as an active ingredient, a method for treating ost... | 01/14/1997 |
| 5527908 | Pyrazolothiazolopyrimidine derivatives Pyrazolothiazolopyrimidine derivatives represented by the Formula ##STR1## and pharmaceutically acceptable salts thereof are useful as anti-inflammatory, analgesic, immunomodulatory and anti-ulcer agents.... | 06/18/1996 |
| 5393752 | Methylpiperazinoazepine compounds, preparation and use thereof Methylpiperazinoazepine derivatives corresponding to formula (I): ##STR1## wherein the symbols X, R1, R2, N1 and N2 have different meanings and pharmaceutically acceptable salts thereof, preparation and use... | 02/28/1995 |
| 5321021 | Tricyclic pyridine derivatives The compounds are of the class of bi- and tricyclic pyridone derivatives of the formula ##STR1## wherein various substituents are as described in the specification, useful in the control of prevention of muscle tensions, stress conditions, insom... | 06/14/1994 |
| 5286722 | Tetrahydropyridinyldibenzazepine derivatives The invention relates to tetrahydropyridinyldibenzazepine derivatives of the formula I ##STR1## wherein R1 is a substituent selected from the group consisting of hydrogen, halogen, and lower alkyl; R2 is selected from hydrogen, ... | 02/15/1994 |
| 5238936 | Trisubstituted triazines The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents. A compound disclosed is 2,4-diallylamino-6... | 08/24/1993 |
| 5075440 | Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines Novel pyrido[2,3-f] [1,4]thiazepines and novel pyrido[3,2-b] [1,5]benzothiazepines of the formula: ##STR1## These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Also d... | 12/24/1991 |
| 5036066 | Tricyclic pyridine derivatives The compounds are of the class of bi- and tricyclic pyridone derivatives of the formula ##STR1## wherein the various substituent are as described in the specification, useful in the control of prevention of muscle tensions stress conditions, ins... | 07/30/1991 |
| 5015637 | Pyrido[3,4-b]pyrrolo[1,2-e][1,4,5]oxadiazepines There are disclosed various compounds of the formula below, ##STR1## where X is hydrogen, halogen or loweralkyl; Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; R1 is hydrogen, loweralkyl, aryl, arylloweralkyl, diloweralkyla... | 05/14/1991 |
| 4977258 | Benzoxazepinone process Compounds of formula III: ##STR1## wherein R1 is a 5- or 6-membered aromatic heterocyclic group; and R4 and R5 each idependently signify hydrogen, halogen, trifluoromethyl, cyano, nitro, amino or lower alkyl; are usef... | 12/11/1990 |
| 4960784 | Insecticidal substituted indazoles Certain substituted indazoles, including all geometric and stereoisomers thereof, agricultural compositions containing the indazoles and use of the indazoles as insecticides.... | 10/02/1990 |
