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| Number | Title | Issue Date |
| 7407949 | Benzamide derivatives as oxytocin agonists and vasopressin antagonists Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds ... | 08/05/2008 |
| 7229984 | Dibenzoxazepinone derivatives and uses thereof Compounds of the Formula I: wherein m, n, k, A, X, Y, Z, Ar, R1, R2, R3, and R4 are as defined herein. The compounds are useful as 5-HT6 receptor antagonists. Also prov... | 06/12/2007 |
| 7078521 | Process for the preparation of 9-amino substituted 9,10-dihydropyrrolo[2,1-b][1,3]benzotiazepines A process is described for the preparation of compounds with the following formula where the groups are as defined below; in particular, R1 is a substituted amine; said process includes essentially the reaction of pyrrolobenzothiazepin-9-one with amine R | 07/18/2006 |
| 6943156 | Dibenzoxazepine αv integrin receptor antagonist The present invention relates to a novel dibenzoxazepine derivative, its synthesis, and its use as an αv integrin receptor antagonist. More particularly, the compound of the present invention is an antagonist of the integrin receptors αvβ3 and αvβ5 and therefor... | 09/13/2005 |
| 6887838 | Bleach boosting components, compositions and laundry methods Formulation components such as bleach boosting compounds selected from the group consisting of bleach boosters comprising quaternary imine cations, zwitterions, polyions having a net charge of from about +3 to about 3 and mixtures thereof, bleaching species comprisi... | 05/03/2005 |
| 6887868 | Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I): wherein: R1, R2, R3, R4, R5, R6 R7, R8, n, m, and X have any of the value... | 05/03/2005 |
| 6858599 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 02/22/2005 |
| 6806267 | Apoptosis-inducing compounds The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents. ... | 10/19/2004 |
| 6794391 | Derivatives of pyrimido[6.1-a]isoquinolin-4-one The invention provides compounds or salts thereof of the general formula (I): wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; X represents O... | 09/21/2004 |
| 6710041 | Pyrrolo[2,1-B][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity A compound of formula (I): where: R=H, Cl, Br, F, I, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, or C5-C6 cycloalkyl; R1 = | 03/23/2004 |
| 6624159 | Heterocycle carboxamides as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 09/23/2003 |
| 6537987 | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, anti-Alzheimer's agents or anti-acne agents.... | 03/25/2003 |
| 6521769 | Chiral phosphines, transition metal complexes thereof and uses thereof in asymmetric reactions Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include chiral C1-C6 TunaPhos ligands. The ruthenium TunaPhos complex reduces ketones to the corresponding alcohols... | 02/18/2003 |
| 6476017 | Compounds activating pharmacological effect of retinoids A compound represented by the formula (I) or (II) or a salt thereof wherein R1 represents hydrogen atom or a C1-6 alkyl group; R2 and R3 independently represent a hydrogen atom or a C1-6 alkyl group, ... | 11/05/2002 |
| 6387893 | Spirotricyclic substituted azacycloalkane derivatives and uses thereof Spirotricyclic azacycloalkyl compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds is also described. One application of these compounds, which are alpha 1a adrenergic receptor antagonists, is in the treat... | 05/14/2002 |
| 6235730 | 3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions comprising the same 3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): ##STR1## wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstitu... | 05/22/2001 |
| 6214820 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci... | 04/10/2001 |
| 6121256 | Compounds activating pharmacological effect of retinoids A compound represented by the formula (I) or (II) or a salt thereof wherein R' represents hydrogen atom or a C1-6 alkyl group; R2 and R3 independently represent a hydrogen atom or a C1-6 alkyl group, or R2 | 09/19/2000 |
| 6114329 | 5-HT4 receptor antagonists useful in the treatment of gastroinstestinal, cardiovascular and CNS disorders Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--CH2 --Z (I) wherein X is a monocyclic or po... | 09/05/2000 |
| 6008213 | Integrin receptor antagonists Compounds of formula (I) ##STR1## wherein A1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R3 or R4 ; X1 --X2 is CHR1 -... | 12/28/1999 |
| 5998409 | Condensed indole derivatives as 5HT4 -receptor antagonists Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.... | 12/07/1999 |
| 5965553 | Squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, Alzheimer's agents or anti-acne agents.... | 10/12/1999 |
| 5962449 | Tricyclic compounds in treating hyperalgesic conditions and NIDDM The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use fo... | 10/05/1999 |
| 5929069 | Compounds activating pharmacological effects of retinoids A compound represented by the formula (I) or (II) or a salt thereof wherein R1 represents hydrogen atom or a C1-6 alkyl group; R2 and R3 independently represent a hydrogen atom or a C1-6 alkyl group, ... | 07/27/1999 |
| 5852014 | Condensed indole derivatives as 5HT4 -receptor antagonists Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.... | 12/22/1998 |
| 5846968 | N-substituted azaheterocyclic carboxylic acids and esters The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 12/08/1998 |
| 5834459 | Alkyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH | 11/10/1998 |
| 5834462 | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives Novel tricyclic heterocyclic sulfonamide derivatives and sulfonic ester derivatives which have each an antitumor action and are represented by the following general formula (I) and processes for producing the same are provided. These compounds have each a... | 11/10/1998 |
| 5824676 | 5-HT2 receptor ligands Described herein are 5-HT2 receptor-selective compounds of Formula I: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH | 10/20/1998 |
| 5811420 | Fungarrestins Compounds of formula (I), ##STR1## wherein R1 and R2 are independently hydrogen, unsubstituted lower alkyl or lower alkyl substituted by lower alkoxy or lower alkyl thio, or acyl which is unsubstituted or substituted by one or m... | 09/22/1998 |
| 5780633 | Process for the preparation of indolizine derivatives A new process for preparing a compound of the formula: ##STR1##... | 07/14/1998 |
| 5773433 | Substituted tetracyclic oxazepine and thiazepine derivatives This invention concerns the compounds of formula (I), the pharmaceutically acceptable salts and stereoisomeric forms thereof, and also the N-oxide forms thereof. ##STR1## wherein: R1 and R2 each independently are hydrogen; C | 06/30/1998 |
| 5719140 | 2, 3-, 4-, 5-, 6-, 7-, 8-, 9- and /or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2... | 02/17/1998 |
| 5705498 | Piperidine derivatives as 5-HT4 receptor antagonists Compounds of formula (I): ##STR1## wherein Xg is O, S, SO, SO2, CH2, CH, N or NR wherein R is hydrogen or C1-6 alkyl; A is a saturated or unsaturated polymethylene chain of 2-4 carbon atoms; R1g | 01/06/1998 |
| 5661146 | Substituted dibenzoxazepine urea compounds, pharmaceutical compositions and methods of use The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount... | 08/26/1997 |
| 5602121 | Alkyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select... | 02/11/1997 |
| 5602120 | Benzyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select... | 02/11/1997 |
| 5602124 | 5-HT2 receptor ligands Described herein are 5-HT2 receptor-selective compounds of Formula I: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH | 02/11/1997 |
| 5576315 | Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in co... | 11/19/1996 |
| 5538965 | Dopamine receptor ligands Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is select... | 07/23/1996 |
