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| Number | Title | Issue Date |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 6914140 | Asymmetric synthesis process A novel process for the manufacture of compounds of the formula wherein R1 and R2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel p... | 07/05/2005 |
| 6486151 | N-oxides of heterocyclic esters, amides, thioesters, and ketones This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with ... | 11/26/2002 |
| 6458781 | Substituted diarylalkyl amides as calcium channel antagonists The present invention provides compounds that block calcium channels and have the Formula I: ##STR1## The present invention also provides pharmaceutical compositions containing the compounds of Formula I and methods of using them to treat stroke, cer... | 10/01/2002 |
| 6268530 | Process to prepare 5-formylvaleric acid Process to separate linear 5-formylvaleric acid from a mixture of 5- and 3- and 4-formylvaleric acids, wherein the separation is performed by fractional extraction with two immiscible solvents of which one solvent is an aqueous solvent and the other solve... | 07/31/2001 |
| 6251892 | N-oxides of heterocyclic esters, amides, thioesters, and ketones This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with... | 06/26/2001 |
| 6160126 | Synthetic Intermediates for the preparation of N, N'-Di-substituted isothiourea derivatives and N-cyclic(methyl)-N'-Substituted isothiourea derivatives Novel Intermediates ##STR1## wherein R is a substituted or unsubstituted hydrocarbon residue or acyl group; X is an electron withdrawing group; Y1 and Y2, which are the same or different, are each independently oxygen or sulfur;... | 12/12/2000 |
| 6069245 | Asymmetric synthesis of azepines A novel process for the manufacture of compounds of the formula ##STR1## wherein R1 and R2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel process for making compounds of ... | 05/30/2000 |
| 6054452 | N-oxides of heterocyclic esters, amides, thioesters, and ketones This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with... | 04/25/2000 |
| 6054579 | Synthesis of substituted lactams The invention relates to an efficient and facile method for the preparation of substituted lactams, as described herein. The method comprises reacting a difunctional component containing an activated carbon, an amine capable of forming an imine with the a... | 04/25/2000 |
| 6028192 | Process for the preparation of diacylimides The present invention relates to a process for the preparation of compounds of the formula 1 ##STR1## by reacting a secondary acid amide of the formula 2 ##STR2## with an acid chloride of the formula 3 ##STR3## in the presence of N,N-d... | 02/22/2000 |
| 6013606 | Substituted cinnamic oxime and hydroxamide derivatives Substituted cinnamic oxime derivatives I and cinnamic hydroxamide derivatives II ##STR1## (R1= halogen, NO2, CN, CF3 ; R2 =H, halogen; R3= H, halogen, C1 -C6 -alkyl, C1... | 01/11/2000 |
| 5902882 | Assymetric synthesis of azepines A novel process for the manufacture of compounds of the formula ##STR1## wherein R1 and R2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel process for making compounds of ... | 05/11/1999 |
| 5856318 | Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for CNS disorders Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each o... | 01/05/1999 |
| 5847123 | Imide derivatives for inhibiting the production of interleukin-1ଲ and the production of tumor necrosis factor Imide compounds having a propioloyl group or pharmaceutically acceptable salts thereof which exhibit potent activities to inhibit the production of Interleukin 1-ଲ and also the production of Tumor Necrosis Factor . These imide compounds are u... | 12/08/1998 |
| 5688944 | Carbamazepine derivatives The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound s... | 11/18/1997 |
| 5677444 | Method for the preparation of ଲ-ketothioamide compound A novel and simple method is proposed for the synthetic preparation of an N,N-disubstituted ଲ-ketothioamide compound represented by the general formula R1 R2 N--CS--CH2 --CO--R3, in which R1 and R | 10/14/1997 |
| 5594134 | Process of synthesizing N-acyl auxiliaries A process of synthesizing N-acyl auxiliary compounds is disclosed. A compound of the formula: ##STR1## is reacted with an anhydride in the presence of a lithium salt and an amine base to produce the N-acylated auxiliary.... | 01/14/1997 |
| 5510477 | Process for the acylation of lactams High quality acyl lactam imides are prepared by reacting an acyl lactam of the formula ##STR1## where 5 carbon atoms and an acylating acid of the formula R'CO2 H or by reacting a lactam, an anhydride of the formula (RCO)2 O wher... | 04/23/1996 |
| 5308520 | Heterocyclic compounds useful as additives for lubricant and fuel compositions Various heterocyclic compounds have been discovered that impart improved fuel economy and friction modification to lubricant and fuel compositions. These heterocyclic compounds of the invention preferably contain nitrogen and may be further reacted with h... | 05/03/1994 |
| 5155102 | 1-alkyl-3-(acylamino)-&3xb5;-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same 1-alkyl-3-(acylamino)-&3xb5;-caprolactames of formula (1) ##STR1## wherein R is selected from the group consisting of: pyrrolidin-2-one-1-acetyl, p-methoxybenzoyl, N-benzyloxycarbonyl-(S)-prolyl, phenylbutanoyl, 3-trifluoromethylbenzoyl, 3,4,5-trimethoxybenzoy... | 10/13/1992 |
| 5153316 | Intermediates for herbicidal phenylimidazolones The present invention relates to novel phenylimidazolone compounds of the formula ##STR1## wherein A is a bond or C.dbd.T; R is --H, Alk, halo-Alk, cyano-Alk, or phenyl; R1 is --H, Alk, halogen, halo-Alk, --CN; or when A is a bond, R and R... | 10/06/1992 |
| 5142044 | Penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said sy... | 08/25/1992 |
| 5093031 | Surface active lactams The invention relates to properties and uses of N-hydrocarbon substituted lactams, particularly N-alkyl substituted lactams having the formula ##STR1## wherein R' is a hydrophobic radical such as linear or branched chain alkyl group containing from 8... | 03/03/1992 |
| 5059687 | Process for the condensation of imides and alcohols or amines A process for the condensation of imides and alcohols or amines to ester acyl lactams, ester amide acyl lactams or amide acyl lactams by reacting a polyol or polyamine in the liquid phase with an acyl lactam compound is disclosed.... | 10/22/1991 |
| 5043441 | Compositions comprising 1-substituted azacycloalkanes This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents ... | 08/27/1991 |
| 5041545 | 2-hydroxybenzophenone hydrazides and derivatives thereof Hydrazide functionalized 2-hydroxybenzophenone ultraviolet light and heat stabilizers and derivatives are disclosed having the general formula: ##STR1## wherein R1, R2, R3, R4, R5, R6, X, Y... | 08/20/1991 |
| 5021439 | Cerebral function ameliorating agents related to Tan-950 A A compound having the formula (I) or (II) ##STR1## wherein R1 is a hydrogen atom or an organic residue bonded via a carbon atom, R2 is a hydrogen atom or a N-protecting group, --COR3 is an optionally esterified or ami... | 06/04/1991 |
| 4970306 | Trans-cyclohexane-1,4-diisocyanate which is completely or partially blocked with epsilon-caprolactam: and the manufacture and use of the same The invention relates to trans-cyclohexane-1,4-diisocyanate which is completely or partially blocked with epsilon-caprolactam and a method of manufacturing the same wherein 1 mole trans-cyclohexane-1,4-diisocyanate is reacted with 1 to 2 moles epsilon-cap... | 11/13/1990 |
| 4801586 | Penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said sy... | 01/31/1989 |
| 4784782 | Heterocyclic compounds useful as additives for lubricant and fuel compositions Various heterocyclic compounds have been discovered that impart improved fuel economy and friction modification to lubricant and fuel compositions. These hetrocyclic compounds of the invention preferably contain nitrogen and may be further reacted with hy... | 11/15/1988 |
| 4717415 | Herbicidal compositions of triazinone or triazinedione derivatives and haloalkanoic acid amide synergists Herbicidal compositions comprising ##STR1## and as a synergist an amide of the formula ##STR2## in which R is halogenoalkyl.... | 01/05/1988 |
| 4692520 | N-substituted acyl-lactam compound The invention relates to the N-substituted acyl-lactam compound of the formula: ##STR1## where R' is a bivalent cyclic or non-cyclic alkyl, aralkyl, alkaryl or aryl radical R" a bivalent radical having the following general formula ##STR2## ... | 09/08/1987 |
| 4692521 | N-substituted acyl-lactam compound The invention relates to N-substitutecd acyl lactam compounds of the formula ##STR1## where R is a polyol residue originating from a polyol with the formula R-(OH)x where x is a numberࣘ2 R' a bivalent cyclic or non-cyclic alkyl, aralkyl,... | 09/08/1987 |
| 4683304 | Process for preparing an acyl-lactam compound The invention relates to a process for preparing an acyl-lactam compound characterized in that the reaction product of a lactam with a dicarboxylic acid anhydride is reacted with a polyol at a temperature of 150° C. at most. These acyl-lactam compounds a... | 07/28/1987 |
| 4644051 | Catalytic reaction of polyol with bis-acyl lactam The invention concerns a simple process for preparing an ester acyllactam and/or esteramide acyllactam by the catalytic condensation of imide and alcohol, characterized in that a polyol and an acyllactam compound are reacted in the liquid state in the pre... | 02/17/1987 |
| 4608201 | Process for preparing lactam imides A process for preparing a lactam imide involves reacting together a lactam, a non-volatile carboxyl group-containing material, and an anhydride of a volatile carboxylic acid with the proviso that an appreciable amount of non-volatile carboxyl group-contai... | 08/26/1986 |
| 4540516 | Process for the preparation of an N-substituted carbamoyl-lactam compound The invention concerns a simple, reliable and reproducable process for the preparation of an N-substituted carbamoyl lactam compound, for example of the following formula: ##STR1## where: R is a polyol originating from a polyol having the formula ... | 09/10/1985 |
| 4540515 | N-Substituted carbamoyl-lactam compound The invention concerns an N-substituted carbamoyl-lactam compound characterized by the formula: ##STR1## where in the formula: R is a polyol radical from a polyol having the formula R--(OH)xi, where xi is an integerࣙ2 R' is an... | 09/10/1985 |
| 4528392 | Aromatic compounds as antiallergic agents There are disclosed compounds of the formula ##STR1## wherein X is OR2, SR2, N(R2)2 or halo; W is --CH2 --, ##STR2## Y is --CH2 O--, --OCH2 --, --CH2 S--, --SCH | 07/09/1985 |
