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| Number | Title | Issue Date |
| 8022203 | Amino derivatives of beta-homoandrostanes and beta-heteroandrostanes New aminoalkoxyimino derivatives at position 3 of substituted B-homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hype... | 09/20/2011 |
| 7915402 | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture ... | 03/29/2011 |
| RE41366 | Total synthesis of galanthamine, analogues and derivatives thereof The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom, R2=a hydroxy group, R1 and R2 together form ═O, R3, R4 | 06/01/2010 |
| 7109327 | Total synthesis of galanthamine, analogues and derivatives thereof The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form ═O, R3, R4 | 09/19/2006 |
| 6958330 | Polycyclic α-amino-ε-caprolactams and related compounds Disclosed are polycyclic α-amino-ε-caprolactams and related compounds which are useful as synthetic intermediates in the preparation of inhibitors of β-amyloid peptide release and/or its synthesis. ... | 10/25/2005 |
| 6696436 | B-homoestra-1,3,5(10)-trienes as modulators of tubulin polymerization The invention provides B-ring expanded estra-1,3,5(10)-triene compounds of general formula (1) which modulate the polymerization of tubulin and/or the depolymerization of microtubules. The compounds have anti-angiogenic and anti-tumor activity. The invent... | 02/24/2004 |
| 6638925 | Benzazepine derivatives, medicaments containing the same and their use to prepare medicaments New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) ##STR1## and new compounds of the general formula (III) ##STR2## Drugs, containing compounds of formulas (I) and/or (III), which can be used ... | 10/28/2003 |
| 6602866 | Mercaptoacetylamide derivatives, a process for their preparation and their use This invention discloses and claims a series of mercaptoacetylamide derivatives of formula I. Also disclosed and claimed are pharmaceutical compositions incorporating these compounds and processes for preparing said compounds. The use of said compounds fo... | 08/05/2003 |
| 6303620 | Compounds with growth hormone releasing properties Disclosed are 4,4-disubstituted and 3,3-disubstituted piperidine compounds of formula I ##STR1## wherein D, E, G, J, R1, a, b, c, and d are defined in the specification, compositions containing them, and their use for treating medical diso... | 10/16/2001 |
| 5872251 | Process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 02/16/1999 |
| 5854273 | Bisimide compounds A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C | 12/29/1998 |
| 5849908 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 12/15/1998 |
| 5847135 | Inhibitors of interleukin-1ଲ converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1ଲ converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also rel... | 12/08/1998 |
| 5734049 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 03/31/1998 |
| 5718912 | Muscarine agonists This invention is concerned with novel 1-cycloalkylpioeridin-4-yl!-2H benzimidazolones, their compositions and method of use. The novel compounds are selective muscarinic agonists of the m2 subtype with low activity at the m3 subtype. The compounds are ... | 02/17/1998 |
| 5641880 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.... | 06/24/1997 |
| 5604221 | Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.... | 02/18/1997 |
| 5576313 | Inhibitors of farnesyl-protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 11/19/1996 |
| 5302716 | Fused benzazepines Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.... | 04/12/1994 |
| 5294611 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones The invention provides novel 2,3,6 substituted quinazolinones having the formula: ##STR1## wherein R6, R and X are as described in the specification, which have activity as angiotensin II (AII) antagonists.... | 03/15/1994 |
| 5196535 | Intermediates for producing antipicornaviral pyridazinamines Piperidinyl, pyrrolidinyl, azepinyl and piperazinyl pyridazines of formula ##STR1## wherein one or two carbon atoms of the ##STR2## moiety may be substituted with C1-4 alkyl, C1-4 alkyloxy or two carbon atoms of the CH... | 03/23/1993 |
| 4220775 | Preparation of 4-aza-17-substituted-5-androstan-3-ones useful as 5-reductase inhibitors A method of preparing a compound of the formula: ##STR1## where Formula (I) may also have the structure of partial Formula (III); wherein, ##STR2## R' is hydrogen or methyl; R" is hydrogen or ଲ-methyl; R'" is ଲ-methyl or hydroxy; Z i... | 09/02/1980 |
