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| Number | Title | Issue Date |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7250410 | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis... | 07/31/2007 |
| 6916805 | Quinoxalinones as serine protease inhibitors This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable co... | 07/12/2005 |
| 6458784 | Vitronectin receptor antagonists Pharmaceutically active benzodiazapine compounds of formula (I) are disclosed. These compounds inhibit the vitronectin receptor and are useful for treatment of osteoporosis. ##STR1##... | 10/01/2002 |
| 6403578 | Bicyclic fibrinogen antagonists This invention relates to compounds of the formulae: ##STR1## wherein A1 is O, S, N--R1 or CHR1 ; A4 is N--R4 or CHR4 ; R2 is a sidechain containing an acid or ester group; R1, ... | 06/11/2002 |
| 6117866 | Bicyclic fibrinogen antagonists Certain compounds within formula (I) are inhibitors of platelet aggregation: ##STR1## wherein A1 is NH or CH2 ; R is H, C1-6 alkyl, benzyl or a carboxy protecting group; R3 is C1-6 alkyl, Ar-C0-6... | 09/12/2000 |
| 6100254 | Inhibitors of protein tyrosine kinases Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine ki... | 08/08/2000 |
| 5843941 | Ras farnesyl transferase inhibitors Benzodiazepine derivatives represented by the structure below are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases foe which in... | 12/01/1998 |
| 5662911 | Benzodiazepine protein conjugates Benzodiazepine protein conjugates of the formula I ##STR1## wherein R1 is hydrogen, a methyl group or R, R2 is hydrogen, a hydroxyl or an OR group, with R1 or R2 containing an R group, R3 is a halogen, NO2 or NH2, X is hydrogen or a halogen, wherein R is ... | 09/02/1997 |
| 5324726 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## wherein: R3 is ##STR2## --NH(CH2)2 --3 NHCOR7, ##STR3## or --X11 NR18 SO2 (CH2)q... | 06/28/1994 |
| 5175159 | 3-substituted-1,4-benzodiazepines as oxytocin antagonists Compounds of Formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarean delivery. ##STR1##... | 12/29/1992 |
| 5013836 | Process for methylating a hindered nitrogen atom in a polysubstituted diazacycloalkan-2-one The difficulty of methylating a hindered piperidinyl, piperazinyl, or diazepinyl group with an Eschweiler-Clarke ("E-C") procedure without using a large molar excess (more than double) of formaldehyde is surprisingly found to be non-existent in the case o... | 05/07/1991 |
| 4820834 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 04/11/1989 |
| 4656026 | Magnetic resonance (MR) image enhancement compounds for specific areas of the brain An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds, such as sterically hindered free radical nitroxide compoun... | 04/07/1987 |
| 4579685 | Process for preparing 1-substituted-1,4-benzodiazepine derivatives Improvement in the production of psychotropic 1-substituted-1,3-dihydro-1,4-benzodiazepin-2-ones starting from 2-(1-substituted)amino-benzophenonimines through novel intermediates of the formula: ##STR1## (wherein R is hydrogen, methyl or benzyl... | 04/01/1986 |
| 4560684 | 1,4-Benzodiazepine derivatives 1,4-Benzodiazepine derivatives of the formula: ##STR1## (in which R1 is pyrrolidinyl or piperidinyl each optionally substituted by C1-3 alkyl, phenyl-C1-3 alkyl, C1-5 alkanoyl, or C2-5 alkoxycarb... | 12/24/1985 |
| 4292240 | 2-Keto-1,4-diazacycloalkanes Novel polysubstituted 2-keto-1,4-diazacycloalkanes are powerful stabilizers for materials subject to ultraviolet (UV) light degradation, particularly for polyolefins. The cyclic 2-keto compounds of this invention have (a) a fixed two-carbon bridge between... | 09/29/1981 |
| 4160099 | Labile, non-heterocyclic quaternary ammonium salt/esters as transient derivatives Labile quaternary ammonium salts of the following formula (I) and (II) are provided: ##STR1## wherein ##STR2## represents a tertiary aliphatic amine; wherein ##STR3## represents an unsaturated amine; wherein R represents a member selec... | 07/03/1979 |
| 4151285 | 1,5-Disubstituted-1,2-dihydro-2H-1,4-benzodiazepin-2-ones 1,5-Disubstituted-1,2-dihydro-2H-1,4-benzodiazepin-2-ones of the formula ##STR1## wherein R is hydrogen or fluoro, R1 is hydrogen, fluoro chloro, bromo or trifluoromethyl, and n is 2 to 4, having anticonvulsant activity and useful as anti-... | 04/24/1979 |
| 3991048 | Process for the preparation of 1,4-benzodiazepine derivatives A 1,4-benzodiazepine derivative, or a pharmaceutically acceptable acid salt thereof, of the formula, ##SPC1## Wherein R1 is hydrogen, halogen, nitro or trifluoromethyl; R2 and R3 are independently hydrogen, halogen, lower ... | 11/09/1976 |
| 3989681 | 7-Azoxy substituted-1,4-benzodiazepin-2-ones Novel 1,4-benzodiazepin-2-ones of the formula ##SPC1## Wherein R1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl-lower alkyl, hydroxylower alkyl, lower alkoxy-lower alkyl and di-lower alkylamino-lower alkyl; R2 | 11/02/1976 |
| 3970645 | 1,4-Benzodiazepine derivative The invention relates to new 1,4-benzodiazepine derivatives of the formula ##SPC1## Wherein R1 is hydrogen, halogen, or the trifluoromethyl group, R2 and R3 are alkyl groups, and n is an integer from 1 to 4, and acid addit... | 07/20/1976 |
