Famous Patents
3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 7390801 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 06/24/2008 |
| 7250410 | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis... | 07/31/2007 |
| 7029918 | Water-soluble derivatives of lipophilic drugs A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): G-(L)n—Y; (I) where G is a lipophilic drug; L is a linker which is an alkyl group or heter... | 04/18/2006 |
| 6686350 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 02/03/2004 |
| 6492553 | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.... | 12/10/2002 |
| 6462037 | 1,4-benzodiazepin-2-ones useful as HIV reverse transcriptase inhibitors The present invention relates to 1,4-benzodiazepin-2-ones of Formula (I): ##STR1## or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pha... | 10/08/2002 |
| 6350870 | Process for preparing pure crystalline lorazepam The present invention provides a process for preparing crystalline lorazepam substantially free of bound solvent from a lorazepam alcohol solvate or hydrate by suspending the lorazepam solvate in an organic medium selected from ethyl acetate, cyclohexane,... | 02/26/2002 |
| 6255479 | Process for the preparation of -oxolactams A method for preparing an -oxolactam comprising, reacting a corresponding -diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding -oxolactam.... | 07/03/2001 |
| 6121258 | 1,5-heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibito... | 09/19/2000 |
| 6100254 | Inhibitors of protein tyrosine kinases Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine ki... | 08/08/2000 |
| 6015791 | Serine protease inhibitors-cycloheptane derivatives The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors, including inhibitors for human neutrophil elastase. Compoun... | 01/18/2000 |
| 5662911 | Benzodiazepine protein conjugates Benzodiazepine protein conjugates of the formula I ##STR1## wherein R1 is hydrogen, a methyl group or R, R2 is hydrogen, a hydroxyl or an OR group, with R1 or R2 containing an R group, R3 is a halogen, NO2 or NH2, X is hydrogen or a halogen, wherein R is ... | 09/02/1997 |
| 5597922 | Glycine receptor antagonist pharmacophore Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and D... | 01/28/1997 |
| 5302715 | Benzodiazepine derivatives The present invention is directed to novel benzodiazepine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the benzodiazepine metabolites. The resulting ... | 04/12/1994 |
| 5175159 | 3-substituted-1,4-benzodiazepines as oxytocin antagonists Compounds of Formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarean delivery. ##STR1##... | 12/29/1992 |
| 4820834 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 04/11/1989 |
| 4808605 | Tetrahydronaphthalene derivatives as calcium antagonists Compounds of the formula ##STR1## wherein R is lower-alkyl, R1 is halogen, R2 is C1 -C12 -alkyl, R3 is hydroxy, lower-alkoxy, lower-alkyl-carbonyloxy, lower-alkoxy-lower-alkylcarbonoyloxy, lower-... | 02/28/1989 |
| 4777169 | Benzodiazepine derivatives Benzodiazepine derivatives useful in immunoassays for benzodiazepines.... | 10/11/1988 |
| 4560684 | 1,4-Benzodiazepine derivatives 1,4-Benzodiazepine derivatives of the formula: ##STR1## (in which R1 is pyrrolidinyl or piperidinyl each optionally substituted by C1-3 alkyl, phenyl-C1-3 alkyl, C1-5 alkanoyl, or C2-5 alkoxycarb... | 12/24/1985 |
| 4412952 | Process for 3-hydroxy benzodiazepinones Conversion of 3-acyloxy-benzodiazepin-2-ones into corresponding 3-hydroxy benzodiazepin-2-ones is carried out efficiently with potassium hydroxide or potassium alkoxide as catalyst in lower alkanol solvent at a pH of 11-11.5. The final products, which inc... | 11/01/1983 |
| 4388313 | Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof The disclosure is directed to new 3-hydroxy-1,4-benzodiazepine-2-ones and to the process for the preparation thereof. The compounds of the invention have the structural formula ##STR1## in which R is methoxy or nitrile, R1 is hydrogen, hal... | 06/14/1983 |
| 4313943 | 7-Chloro-2,3-dihydro-5-phenyl-1-propargyl-1H-1,4-benzodiazepine-2-one, and a pharmaceutical composition thereof The invention relates to 1-propargyl-5-(halo) phenyl-1,4-benzodiazepines, and particularly to 7-chloro-2,3-dihydro-5-phenyl-1-propargyl-1H-1,4-benzodiazepine-2-one endowed with psycho-sedative, low myorelaxant, high anxiolytic, anticonvulsant and hyp... | 02/02/1982 |
| 4261987 | 3-Di-n-propyl-acetoxy-benzodiazepine-2-ones and pharmaceutical compositions thereof Novel 3-Di-n-Propyl-Acetoxy-Benzodiazepine-2-Ones and use thereof as anti-convulsant compounds.... | 04/14/1981 |
| 4133809 | 4H-S-Triazolo[4,3-2][1,5]benzodiazepin-5-ones Compounds of the following formula ##STR1## are useful as central nervous system depressants, tranquilizers, sedatives, growth promotors, anti-convulsants and muscle relaxants in mammalian species.... | 01/09/1979 |
| 4083948 | Benzodiazepine radioimmunoassay using I125-label An improved radioimmunoassay for benzodiazepines such as diazepam, chlordiazepoxide, oxazepam, demoxepam and metabolites thereof is disclosed. Such immunoassay employs novel 125 I-labelled 4'-hydroxy derivatives of these compounds as tracer.... | 04/11/1978 |
| 4043989 | Oxazepam derivatives for immunoassay reagents Compounds are provided for use in the preparation of reagents which can be used in immunoassays for benzdiazepines, particularly as their urinary metabolites. The compounds are non-oxo-carbonyl derivatives conjugated to the 3-position of the benzdiazepine... | 08/23/1977 |
| 4021469 | Process for preparing N-phenylcarbamates Alkyl or Aralkyl N-[2-aroyl]phenylcarbamates are prepared by reacting a 3-aryl-2-indolinone with oxygen in the presence of an alkali metal alkoxide or aralkoxide.... | 05/03/1977 |
