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| Number | Title | Issue Date |
| 7294631 | Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-]pyrimidin-6-one derivatives The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention rela... | 11/13/2007 |
| 7279471 | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydra... | 10/09/2007 |
| 7232816 | Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them The invention relates to novel substituted pyrazolo[4,3-e]-diazepines of general formula: to pharmaceutical compositions containing them, to their use as medicinal products and to processes for preparing them. | 06/19/2007 |
| 7151097 | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid... | 12/19/2006 |
| 7122662 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 10/17/2006 |
| 7064119 | Fused bicyclic pyrimidine derivatives A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following general formula (1): ... | 06/20/2006 |
| 7049310 | Fab I inhibitors Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections. ... | 05/23/2006 |
| 6867208 | Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A—B—D—E—F—G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the inven... | 03/15/2005 |
| 6867298 | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or a... | 03/15/2005 |
| 6602865 | Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) ##STR1## and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and neuroprotective properties.... | 08/05/2003 |
| 6573259 | Inhibitors of interleukin-1ଲ converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1ଲ converting enzyme ("ICE"). This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical com... | 06/03/2003 |
| 6426413 | Inhibitors of caspases The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1ଲ converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The c... | 07/30/2002 |
| 6294525 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: ##STR1## wherein A, R1, R2, R2a,... | 09/25/2001 |
| 6121258 | 1,5-heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibito... | 09/19/2000 |
| 6069114 | 2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators Compounds of the formula (I) and their salts ##STR1## in which R1 to R6, Y1, to Y2, Y3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepa... | 05/30/2000 |
| 6015791 | Serine protease inhibitors-cycloheptane derivatives The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors, including inhibitors for human neutrophil elastase. Compoun... | 01/18/2000 |
| 6013458 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic... | 01/11/2000 |
| 5955607 | Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparations comprising them Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly efficacious substances for producing medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular ... | 09/21/1999 |
| 5925635 | N-(amidinophenyl) cyclourea analogs as factor XA inhibitors The present application describes N-(amidinophenyl)cyclourea analogs of formula I: ##STR1## which are useful as inhibitors of factor Xa.... | 07/20/1999 |
| 5821241 | Fibrinogen receptor antagonists Compounds of the invention have the formula ##STR1## The compounds have fibrinogen receptor antagonist activity.... | 10/13/1998 |
| 5710286 | Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors This invention relates to novel compounds and derivatives thereof containing a trioxepane protected diol in addition to a hydrazone, hydrazine, amine, or cyclic urea moiety; methods for the preparation of said compounds; and the use of said compounds in p... | 01/20/1998 |
| 5693637 | Bicycle derivatives, their preparation and use The description relates to bicyclene derivatives of formula (I) in which A, B, D, E, G, K, L, R1, R2, Z1 and Z2 have the meanings given in the description, and their production. These compounds are suitable for ... | 12/02/1997 |
| 5679673 | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders Certain aralkyl diazabicycloalkyl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each of R, R1, R4 | 10/21/1997 |
| 5656627 | Inhibitors of interleukin-1ଲ converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1ଲ converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also rel... | 08/12/1997 |
| 5466797 | Intermediates for the preparation of cyclic urea This invention relates to novel compounds and derivatives thereof containing a trioxepane protected diol in addition to a hydrazone, hydrazine, amine, or cyclic urea moiety; methods for the preparation of said compounds; and the use of said compounds in p... | 11/14/1995 |
| 5064825 | Angiotensin II antagonists Novel substituted imidazo-fused 7-member ring heterocycles of the formulae (I) and (Ia), which are useful as angiotensin II antagonists, are disclosed. ##STR1##... | 11/12/1991 |
| 5008263 | Diazepine antiallergy agents Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or isothiazole, X is O, S or NH Y is 1,4 phenylene or a group o... | 04/16/1991 |
| 5002944 | Compounds having cardiotonic activity Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure: ##STR1## where A is ##STR2## R1 | 03/26/1991 |
| 4939251 | Novel spirolactones Novel 1-azaspiro[4.4] lactams are produced by reaction of at least one hydroxy-containing primary amino compound with a 4-ketodiacid compound or a 1,6-dioxaspiro[4.4]lactone. Molar excesses of amion compound result in production of spirodilactams, while l... | 07/03/1990 |
| 4895942 | Novel epoxy compounds Novel epoxyalkoxy-containing [4.4] spirodilactams having ring nitrogen atoms in the 1- and the 6- ring positions and having a substituent on each ring nitrogen atom, at least one of which substituents contains an epoxyalkyl moiety. Such epoxy compounds ar... | 01/23/1990 |
| 4881967 | Heterocyclic 2,3-dihydrobenzofuran herbicides This invention pertains to novel heterocyclic 2,3-dihydrobenzofuran and chromane compounds, including stereoisomers, agriculturally suitable composition containing them, and their use as broad spectrum herbicides.... | 11/21/1989 |
| 4859672 | Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure ##STR1## wherein: A is ##STR2## and R | 08/22/1989 |
| 4742165 | 2-piperazinopyrimidine derivatives The present invention relates to novel 2-piperazinopyrimidine derivatives represented by the following general formula [I] which are useful as, for example, an active ingredient of herbicides ##STR1## wherein R1 is a hydrogen atom or an ar... | 05/03/1988 |
| 4705853 | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Aromatic azepinones and thiones having the formula ##STR1## wherein; A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen-containing rad... | 11/10/1987 |
| 4642343 | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Aromatic azepinones and thiones having the formula ##STR1## wherein: A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen containing rad... | 02/10/1987 |
| 4592866 | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Aromatic azepinones and thiones having the formula ##STR1## wherein; A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen containing rad... | 06/03/1986 |
| 4508730 | 1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(3H)-one derivatives a process for preparing them and their use as anticonvulsant and anti-anxiety agents 1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(3H)-one derivatives of the formula ##STR1## wherein R is (C1-4)alkyl, R1 stands for hydrogen, methyl, ethyl, phenyl, bromo, chloro or nitro, R2 is hydrogen or (C1-4... | 04/02/1985 |
| 4402970 | 1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(1H)-one derivatives 1,7-Dihydro-pyrrolo[3,4-e][1,4]diazepin-2(1H)-ones of the formula ##STR1## wherein R is lower alkyl, R1 stands for hydrogen, methyl, ethyl or phenyl, R2 is hydrogen or lower alkyl and R3 is hydrogen, chloro, fluoro, b... | 09/06/1983 |
| 4391817 | Pyrrolo-diazepine derivatives and their pharmaceutical compositions A new class of pyrrolo-diazepines with anticonvulsant and anti-anxiety activity of the general formula ##STR1## wherein R is (C1 -C4)alkyl, R1 is chloro, bromo or nitro, R2 is hydrogen or (C1 -C | 07/05/1983 |
| 4305952 | 8-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-B)(1,4)-diazepine-1H, 4H-5,7-diones, and medicaments containing these 8-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-b)(1,4)diazepine-1H,4H-5,7-diones of the formula ##STR1## in which R1 through R5 are as defined in the specification, and medicaments containing these having an anxiolytic action.... | 12/15/1981 |
