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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 7323458 | Dihydrobenzodiazepins and their use for treating dyslipidemia The invention concerns a benzodiazepin derivative of formula (I) and their use for treating dyslipidemia, atherosclerosis, diabetes and its complications. ... | 01/29/2008 |
| 7317005 | Tricyclic benzodiazepines as vasopressin receptor antagonists The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the prese... | 01/08/2008 |
| 7238702 | Dihydroquinazolinones as 5HT modulators The present invention relates to modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating obesity using such compounds and compositions. ... | 07/03/2007 |
| 7151097 | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid... | 12/19/2006 |
| 7041661 | Use of thiazolobenzoheterocycles for treating multiple sclerosis The invention relates to the use of compound of Formula I in treating patients for inflammatory or neuropathic pain as well as various symptoms of multiple sclerosis ... | 05/09/2006 |
| 6951853 | Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids Novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as well as processes for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids are dislcosed. More particularly, present invention relates to a process for the preparation of novel pyrrolo[2,... | 10/04/2005 |
| 6838455 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 01/04/2005 |
| 6774125 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 08/10/2004 |
| 6713475 | Tricyclic benzodiazepines as vasopressin receptor antagonists The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the prese... | 03/30/2004 |
| 6696438 | Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 02/24/2004 |
| 6683075 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 01/27/2004 |
| 6653303 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 11/25/2003 |
| 6482821 | Vitronectin receptor antagonists, their preparation and their use Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I, A--B--D--E--F--G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their u... | 11/19/2002 |
| 6462037 | 1,4-benzodiazepin-2-ones useful as HIV reverse transcriptase inhibitors The present invention relates to 1,4-benzodiazepin-2-ones of Formula (I): ##STR1## or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pha... | 10/08/2002 |
| 6387895 | Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A--B--D--E--F--G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitron... | 05/14/2002 |
| 6369221 | Thiazolobenzoheterocycles, preparation and medicines containing same Disclosed are thiazolobenzoheterocycles of the general formula ##STR1## Including their isomers, racemates, enantioners and salts thereof, as well as processes for preparing these compounds and medicaments containing them. Also disclosed are novel interme... | 04/09/2002 |
| 6362331 | Process for the preparation of antitumor agents The present invention provides a process for the preparation of a novel pyrrolo[2,1-c][1,4]benzodiazepine of formula VI wherein R is H, OII, OAc and R.sub.1 is H, and n is 3 to 5, by ##STR1## reacting (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzyl]-pyrrol... | 03/26/2002 |
| 6063774 | Tricyclic quinoxaline derivatives as neuroprotective agents Neuroprotective agents have forumula I ##STR1## wherein a is a ring of 6 to 8 members; n and n' are 1 or 2, R2 is hydrogen or oxygen of carbonyl, R1, R2, R3, R4, R5 and R6 independent... | 05/16/2000 |
| 5869487 | Pyrido3,4-B!pyrazines for use as thrombin inhibitors A compound which inhibits human thrombin and where has the structure ##STR1##... | 02/09/1999 |
| 5786352 | Cyclic compounds, their production and use Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C | 07/28/1998 |
| 5770590 | Cyclic compounds, their prudiction and use Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C | 06/23/1998 |
| 5716951 | Tricyclic inhibitors of the vitronectin receptor A tricylic benzodiazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions fo... | 02/10/1998 |
| 5635502 | Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ACE The present invention relates to certain novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and of ACE. These mercaptoacetylamide bicyclic lactam derivatives can be described by the following formula: ##STR1## ... | 06/03/1997 |
| 5532359 | Ras farnesyl transferase inhibitors Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protei... | 07/02/1996 |
| 5401737 | Tricyclic compounds The invention relates to a compound of the formula ##STR1## wherein R1 is aryl which may have suitable substituent(s), X is --O-- or ##STR2## in which R3 is hydrogen or lower alkyl, A is a bond or lower alkylene which ... | 03/28/1995 |
| 5322842 | Tricyclic benzodiazepine derivates, their preparation, and pharmaceutical compositions containing them Tricyclic compounds of the formula: ##STR1## wherein R1 1 is hydrogen or an organic group, R2 is aryl which may have suitable substituent(s), R3 is hydrogen or an acyl group and A is lower alkylene, and pharmaceutically accepta... | 06/21/1994 |
| 5308842 | Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds Conformationally constrained tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds and ring homologs thereof are topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glauc... | 05/03/1994 |
| 5218117 | Process for preparing isoquinoline compounds The invention relates to novel compounds of the general formula (I), ##STR1## The compounds of the invention antagonize the effects of constrictive mediators, e.g. histamine, acetylcholine or serotonin; they show an antiallergic action and possess an... | 06/08/1993 |
| 5155101 | Tricyclic compounds The invention relates to a compound of the formula: ##STR1## wherein R1 is aryl which may have suitable substituents(s), X is --O-- or ##STR2## in which R3 is hydrogen or lower alkyl, A is a bond or lower alkylene whi... | 10/13/1992 |
| 5082839 | Thieno-triazolo-1,4-diazepino-2-carboxylic acid amides The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R1 represents hydrogen, a C1-C.sub.4 straight-chained or branched alkyl which can optionally be substituted by hal... | 01/21/1992 |
| 5008263 | Diazepine antiallergy agents Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or isothiazole, X is O, S or NH Y is 1,4 phenylene or a group o... | 04/16/1991 |
| 4992437 | Thienodiazepine compounds and their pharmaceutical use Thienodiazepine compounds of the general formula ##STR1## wherein R1 and R2 are the same or different and respectively stand for a hydrogen atom, a halogen, an alkyl or an aralkyl, or mean a group wherein R1 and R | 02/12/1991 |
| 4981847 | Tricyclic compounds Tricyclo benzodiazepines are cholecystokinin antagonists.... | 01/01/1991 |
| 4939137 | Ring-fused thienopyrimidinedione derivatives The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and as such are useful as cardiovascular agents.... | 07/03/1990 |
| 4642343 | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Aromatic azepinones and thiones having the formula ##STR1## wherein: A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen containing rad... | 02/10/1987 |
| 4407752 | Azeto-imidazo-diazepines There is presented imidazodiazepines of the formula ##STR1## wherein A together with the two carbon atoms denoted as and ଲ is the group ##STR2## R1 is hydrogen, lower alkyl, lower alkoxymethyl, halogen, nitro or a g... | 10/04/1983 |
| 4316839 | Imidazodiazepine derivatives Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as and ଲ is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) a... | 02/23/1982 |
| 4232016 | 3-Fluorobenzodiazepines 3-Fluoro-2,3-dihydro-1H-1,4-benzodiazepin-2-ones of the formula ##STR1## wherein R1 is H, alkyl or fluorinated alkyl of 1-4 carbon atoms and up to 9 fluorine atoms or cycloalkylalkyl of 4-8 carbon atoms; R2 is phenyl; monohaloph... | 11/04/1980 |
| 4094871 | 1,3,4-Benzotriazepine-2-thiones Novel 1,3,4-benzotriazepine-2-thiones and related tricyclic derivatives having central nervous system activity and a method of use for treating the symptoms of central nervous system depression and anxiety.... | 06/13/1978 |
| 3997591 | Tricyclic benzodiazepines Tricyclic benzodiazepine derivatives (A) bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom a... | 12/14/1976 |
