Quotables
"There is no likelihood man can ever tap the power of the atom."
Robert Millikan, Nobel Prize winner in physics
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8063204 | Benzothiazole and benzoxazole linked pyrrolo[2,1-c] [1, 4] benzodiazepine hybrids as novel antitumour agents and process for the preparation thereof The present invention provides a compound of general formula (9), useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4][benzodiazepine g hybrids of general f... | 11/22/2011 |
| 7429658 | Synthesis of protected pyrrolobenzodiazepines A method of synthesis of a N-10 protected PBD compound of formula (I): via an intermediate of formula (II) or formula (V): ... | 09/30/2008 |
| 7407951 | Pyrrolobenzodiazepines Compounds of formula (I): formula (I) and salts, solvates, chemically protected forms, and prodrugs thereof, are disclosed wherein R2 is selected from: an optionally substituted napthyl group; an optionally substituted thiophenyl or furanyl group; and a p... | 08/05/2008 |
| 7312210 | Pyrrolo[2,1-][1,4]benzodiazepine compounds and processes for the preparation thereof The present invention provides novel pyrrolo [2,1-c][1,4]benzodiazepine compounds. This invention also provides a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine compounds. These novel pyrrolo [2,1-c][1,4]benzodiazepine compounds are useful as... | 12/25/2007 |
| 7271164 | Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives This invention provides compounds of the formula: wherein R1 and R2 are each, independently, H, alkyl, cycloalkyl, —CH2-cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, ... | 09/18/2007 |
| 7271162 | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of formula I having the structure wherein: R1 and R2 are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —S... | 09/18/2007 |
| 7271163 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of the formulae: wherein: R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms; R2 and R | 09/18/2007 |
| 7265105 | Pyrrolobenzodiazepines A compound of the formula II: wherein: R′2 is CHR″2, where R″2 is H. R6 and R9 are H and R7 | 09/04/2007 |
| 7244724 | Pyrrolobenzodiazepines A compound of formula I: or solvate thereof, wherein n is 1 to 10, and M and M′ are independently selected from monovalent pharmaceutically acceptable cations, or together represent a divalent pharmaceutically ... | 07/17/2007 |
| 7189710 | C2-fluoro pyrrolo [2,1−][1,4]benzodiazepine dimers The present invention relates to novel 2-fluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimers useful as antitumour agents and to a process for the preparation thereof. ... | 03/13/2007 |
| 7186828 | Cyclic urea compounds and preparation thereof A method for preparing cyclic urea compounds from at least an activated carbamic acid derivative containing an unprotected primary or secondary amine function, includes a cyclization step which consists in a reaction between the primary or secondary amine function a... | 03/06/2007 |
| 7173026 | Pyrrolo [2,1-c][1,4]benzodiazepine-anthraquinone conjugates useful as antitumour agents The present invention relates to synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone hybrids (V) wherein n=3,4; R=H, OH and to their use as antitumour agents. ... | 02/06/2007 |
| 7067511 | Pyrrolobenzodiazepines Compounds of the formulae Ia and Ib: wherein: A is CH2, or a single bond; R2 is selected from: R, OH, OR, CO2H, CO2R, COH,... | 06/27/2006 |
| 7064121 | N-acylated lipophilic amino acid derivatives Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptabl... | 06/20/2006 |
| 7056913 | C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof. ... | 06/06/2006 |
| 7049311 | Pyrrolbenzodiazepines Compounds of formula (Ia) and (Ib) wherein A is CH2, or a single bond; R2 is selected from: R, OH, OR, CO2H, CO2R, COH, COR, SO2R, CN; R6, R7 and R9 are independently selected fr... | 05/23/2006 |
| 7015215 | Pyrrolo[2,1-c][1,4] benzodiazepines compounds and process thereof The present invention provides Analogues of 1,1′-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) wher... | 03/21/2006 |
| 6979684 | Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide hybrids linked through piperazine moiety as potential antitumour agents. The present invention also relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazep... | 12/27/2005 |
| 6951853 | Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids Novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as well as processes for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids are dislcosed. More particularly, present invention relates to a process for the preparation of novel pyrrolo[2,... | 10/04/2005 |
| 6939869 | Pyrrolo[2,1-c][1,4] benzodiazepine-indole derivatives, their preparation process, and uses of the same Disclosed herein are novel pyrrolo[2,1-c][1,4]benzodiazepine-indole derivatives of formula (I): wherein each of the substituents is given the definition as set forth in the Specification and cl... | 09/06/2005 |
| 6838455 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 01/04/2005 |
| 6800622 | Pyrene-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids useful as anti-cancer agents The present invention relates to a process for the preparation of novel pyrrolo [2,1-c][1,4]benzodiazepine hybrids useful as antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential... | 10/05/2004 |
| 6774125 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 08/10/2004 |
| 6747144 | Collections of compounds A compound of formula (I), wherein: R2 and R3 are independently selected from H, R, OH, OR, ═O, ═CH—R, ═CH2, CH2—CO2R, CH2—CO2H, CH2—SO2R, O—SO2 | 06/08/2004 |
| 6696438 | Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 02/24/2004 |
| 6689881 | Method for preparing substituted [1,4]diazepino[6,7,1-hi]indol-4-ones Method for the preparation of enantiomerically pure diazepino-indolone of formula ##STR1## which comprises the intramolecular cyclization of a product of formula ##STR2## where A, B, X1, X2, Z, Z1, Z2 and R are ... | 02/10/2004 |
| 6683075 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 01/27/2004 |
| 6683073 | Pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepines as potential antitumour agents The present invention relates to a process for the preparation of novel pyrrolo [2,1-c][1,4]benzodiazepines useful as potential antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepines as po... | 01/27/2004 |
| 6660856 | Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues The present invention provides an efficient process for the preparation of pyrrolo [2,1-c][1,4]benzodiazepines (PBDs) represented by the formula (I): ##STR1## which starts from a subsituted 2-amino benzoic acid compound, and involves a step of an intermed... | 12/09/2003 |
| 6653303 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 11/25/2003 |
| 6624159 | Heterocycle carboxamides as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 09/23/2003 |
| 6608192 | Collections of compounds A compound of formula (IV): O is a solid support; L is a linking group or a single bond; X' is selected from CO, NH, S, or O; A is O, S, NH, or a single bond; R2 and R3 are independently selected from: H, R, OH, OR, .dbd.O, .dbd.CH--... | 08/19/2003 |
| 6562806 | Pyrrolobenzodiazepines A compound with formula (I) ##STR1## where R10 is a therapeutically removable nitrogen protecting group; R2 and R3 are independently selected from: H, R, OH, OR, .dbd.O, .dbd.CH--R, .dbd.CH2, CH2 --CO... | 05/13/2003 |
| 6548494 | Tricyclic inhibitors of poly(ADP-ribose) polymerases Compounds of the formula shown below are poly(ADP-ribosyl)transferase inhibitors: ##STR1## Such compounds are useful as therapeutics in treating cancers and in ameliorating the effects of stroke, head trauma, and neurodegenerative disease.... | 04/15/2003 |
| 6525044 | Succinoylamino carbocycles and heterocycles as inhibitors of a-ଲ protein production This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, ... | 02/25/2003 |
| 6365585 | Phosphodiesterase IV-inhibiting diazepinoindoles Metabolites of the products of formula (I) ##STR1## in which A and R are as defined in the description, which are phosphodiesterase 4 inhibitors.... | 04/02/2002 |
| 6239130 | Phosphodiesterase 4-inhibiting diazepinoindolones ##STR1## The present invention presents compounds that inhibit phosphodiesterase 4 having Formula (I). The present invention also provides methods of using the compounds of Formula (I) to prevent or treat asthma, atopic dermatitis, rheumatoid arthritis, i... | 05/29/2001 |
| 6225306 | Biphenyl derivatives and drug composition A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## [In the formula (1), A represents a single bond, --CH2 --, --CO--, --CS-- or --SO2 --; B represents a sin... | 05/01/2001 |
| 5972927 | Diazepinoindoles as phosphodiesterase 4 inhibitors Diazepinoindoles of formula (I), ##STR1## wherein A is mono- to trisubstituted aryl or heteroaryl, and B is an --OR1 or --NR2 R3 group where R1, R2 and R3 are particularly hydrogen, an... | 10/26/1999 |
| 5962337 | Combinatorial 1,4-benzodiazepin-2,5-dione library A method has now been found of synthesizing a combinatorial library of 1,4-benzodiazepin-2,5-diones on solid supports via an aza-Wittig ring closure, said compounds optionally encoded with tags, and to the use of this library in assays to discover biologi... | 10/05/1999 |
