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| Number | Title | Issue Date |
| 7271162 | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of formula I having the structure wherein: R1 and R2 are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, —NH—SO2-alkyl, —S... | 09/18/2007 |
| 7271163 | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives This invention provides compounds of the formulae: wherein: R1 is hydrogen, —C(O)CH3 or alkyl of 1-6 carbon atoms; R2 and R | 09/18/2007 |
| 7271164 | Cyclohepta[b][1,4]diazepino[6,7,1,-hi]indoles and derivatives This invention provides compounds of the formula: wherein R1 and R2 are each, independently, H, alkyl, cycloalkyl, —CH2-cycloalkyl, alkoxy, halogen, fluorinated alkyl, —CN, â€... | 09/18/2007 |
| 5891871 | Substituted 2,3-benzodiazepin-4-ones and the use thereof The invention relates to substituted 2,3-benzodiazepin-4-ones which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS... | 04/06/1999 |
| 5674865 | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 10/07/1997 |
| 5674863 | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 10/07/1997 |
| 5565449 | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t... | 10/15/1996 |
| 5532359 | Ras farnesyl transferase inhibitors Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protei... | 07/02/1996 |
| 5296610 | N-substituted polyamide-imides An N-substituted polyamideimide essentially composed of identical or different repeating units of the formula I ##STR1## where R1 is one of the following tetravalent aromatic radicals ##STR2## and X is a bond or one of the following l... | 03/22/1994 |
| 5175157 | Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them Disclosed are new cyclic amine derivatives of the formula I ##STR1## wherein the substituents are defined in the specification. These compounds are useful as for treating sinus tachycardia.... | 12/29/1992 |
| 4906630 | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.... | 03/06/1990 |
| 4868300 | Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses Compounds of the formula ##STR1## wherein: z is O or I; X is ##STR2## a and b are 0, 1, or 2 and a+b=0, 1 or 2; R, R1, R3, R4, R5 and R6 are each independently hydrogen, alkyl or aralkyl; R | 09/19/1989 |
| 4863920 | Imidazodiazepine derivatives for treatment of disorders of the central nervous system A compound for treating disorders of the central nervous system, which is of the formula wherein A taken together with the two carbon atoms denoted by and ଲ is one of the following groups: ##STR1## R1 is one of the following ... | 09/05/1989 |
| 4824849 | 2 -adrenoceptor antagonistic arylquinolizines Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective 댒 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, plat... | 04/25/1989 |
| 4822880 | Process for the extraction of metal values and novel metal extractants Metal values are extracted from aqueous solutions containing halide or pseudohalide anion using 1,1'-substituted 2,2'-biimidazole or bibenzimidazole compounds. Useful for the solvent extraction of zinc and copper from chloride leach solutions.... | 04/18/1989 |
| 4725686 | Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinonepryidazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same.... | 02/16/1988 |
| 4723003 | Benzopyrrolobenzodiazepines and quinobenzodiazepines The invention relates to benzopyrrolobenzodiazepines and quinobenzodiazepines of the formula ##STR1## where X and Y may be the same or different and each is hydrogen, halogen, CF3, lower alkyl, lower alkoxy, lower alkylthio and lower ... | 02/02/1988 |
| 4710504 | Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective 댒 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, plat... | 12/01/1987 |
| 4666913 | Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses A method for increasing cardiotonic contractility in humans or other animals using a class of hydroxy and aminothiazolyl-benzodiazinone compounds and pharmaceutical compositions including the same.... | 05/19/1987 |
| 4525588 | Chromogenic naphtholactams The invention relates to chromogenic naphtholactams of the general formula ##STR1## wherein Q is the radical of a couplable compound, X is oxygen or ##STR2## wherein R is hydrogen, lower alkyl or aryl, and W is alkylene, cycloalkylene or a 6-mem... | 06/25/1985 |
| 4012373 | Pyrazolo[3',4'-2,3]pyrido[4,5-e]b-benzo-1,5-diazepinones The new pyrazolo[3',4'-2,3]pyrido[4,5-e]b-benzo-1,5-diazepinone compounds having the general formula ##STR1## are useful as central nervous system depressants and anti-inflammatory agents. These compounds also increase the intracellular concentration ... | 03/15/1977 |
