Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7368444 | N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient The present invention relates to the compound presented by formula (I) (wherein all symbols in formula (I) are the same mean as the description shown in the specification.), mitocondorial benzogeazepin receptor (MBR) antago... | 05/06/2008 |
| 7253169 | Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ... | 08/07/2007 |
| 7029918 | Water-soluble derivatives of lipophilic drugs A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): G-(L)n—Y; (I) where G is a lipophilic drug; L is a linker which is an alkyl group or heter... | 04/18/2006 |
| 6686350 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 02/03/2004 |
| 6576760 | Processes for synthesis of cyclic and linear polyamine chelators containing N-monosubstituted coordinating arms Polyamines containing at least two nitrogen atoms monosubstituted with pendant arms capable of coordinating metal cations, or with precursors of such pendant arms, all nitrogen atoms of the polyamines except two being fully substituted and the remaining t... | 06/10/2003 |
| 6521613 | Lactam compounds for penetration enhancement Compounds, compositions and methods are disclosed useful for enhancing penetration of a pharmacologically active substances across skin or tissue membranes. Compounds for use in such compositions and methods are highly water-soluble N-substituted polyalky... | 02/18/2003 |
| 6503898 | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A repr... | 01/07/2003 |
| 6399598 | Diheterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptacle salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of... | 06/04/2002 |
| 6372735 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as... | 04/16/2002 |
| 6344560 | Nitroaromatic solubilizer for nitroxyls in aromatic solvents A nitroaromatic compound is used to enhance the solubility of a nitroxyl compound in an aromatic hydrocarbon solvent.... | 02/05/2002 |
| 6323195 | Galanthamine derivatives as acetylcholinesterase inhibitors This application relates to compounds of the formula ##STR1## wherein R1 is hydrogen, (C1 -C12 alkylcarbonyl, (C1 -C12)alkoxycarbonyl, mono(C1 -C12)alkylaminocarbonyl, or di(C | 11/27/2001 |
| 6262222 | Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be ob... | 07/17/2001 |
| 6207663 | Vitronectin receptor antagonists, their preparation and use Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A--B--D--E--F--G (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as ... | 03/27/2001 |
| 6130231 | Integrin receptor antagonists This invention relates to novel fused heterocycles which are useful as antagonists of the v 댣 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compou... | 10/10/2000 |
| 6121258 | 1,5-heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibito... | 09/19/2000 |
| 6114522 | Process of production of 4-substituted-3-halogeno-1,4-benzoxazepine derivative and salts thereof A process for producing 4-substituted-3-halogeno-1,4-benzoxazepin derivative or the salt thereof comprising: deprotonizing a benzoxazepine derivative having the formula (II): ##STR1## with a base; and then, reacting the deprotonized product with a p... | 09/05/2000 |
| 6051678 | Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be ob... | 04/18/2000 |
| 6034215 | 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease ... | 03/07/2000 |
| 5994537 | Process for preparing azepinone compounds useful in the inhibition of ACE and NEP Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R1, R2, R3, R4... | 11/30/1999 |
| 5981511 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5955606 | N-vinyllactam derivatives and polymer thereof N-vinyllactam derivatives protected at the 3-position are provided and represented by the following formula (I). These are polymerized into homo- and copolymers for use in microlithography of semiconductor manufacture. The polymers are used as a photoresi... | 09/21/1999 |
| 5952327 | Phosphonic acid-substituted benzazepinone-n-acetic acid derivatives process for their preparation and pharmaceutical compositions comprising them Compounds having NEP-inhibitory activity, corresponding to the formula I in which R1 is hydrogen or a group forming a biolabile phosphonic acid ester, R2 is hydrogen or a group forming a biolabile phosphonic acid ester and R3 i... | 09/14/1999 |
| 5952462 | Transition state analogs Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, si... | 09/14/1999 |
| 5945408 | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 08/31/1999 |
| 5942638 | Method of functionalizing polycyclic silicones and the resulting compounds A synthetic process for the selective preparation of reactive polyhedral oligomeric silsesquioxanes (POSS) as well as polyhedral oligomeric silicate (POS) (spherosilicate) is provided. The method claimed herein employs metal catalyzed metathesis reactions... | 08/24/1999 |
| 5939576 | Method of functionalizing polycyclic silicones and the compounds so formed A synthetic process for the selective preparation of reactive polyhedral oligomeric silsesquioxanes (POSS) as well as polyhedral oligomeric silicate (POS) (spherosilicate) is provided. The inventive process employs the use of metal catalyzed hydrosilylati... | 08/17/1999 |
| 5917033 | Structure based design of inhibitors of HIV-1 reverse transcriptase The present invention pertains to a method for designing inhibitors of enzyme human immunodeficiency virus type 1 reverse transcriptase which comprises the steps of: (a) providing a three dimensional model of the receptor site in the prepolymerization com... | 06/29/1999 |
| 5821241 | Fibrinogen receptor antagonists Compounds of the invention have the formula ##STR1## The compounds have fibrinogen receptor antagonist activity.... | 10/13/1998 |
| 5817602 | Herbicidal thiadiazabicyclodecanes Thiadiazabicyclodecanes of formula (I) wherein, Z is oxygen or sulfur; R is an optional substituent and W is an optionally condensed or substituted phenyl radical and the salts, complexes and stereisomers thereof, have good selective pre- and post-emergen... | 10/06/1998 |
| 5750687 | Azepinone compounds useful in the inhibition of ACE and NEP Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: A is ##STR2## and wherein R, R1, R2 | 05/12/1998 |
| 5750680 | N-vinyllactam derivatives and polymer thereof N-vinyllactam derivatives protected at the 3-position are provided and represented by the following formula (I). These are polymerized into homo- and copolymers for use in microlithography of semiconductor manufacture. The polymers are used as a photoresi... | 05/12/1998 |
| 5705890 | Tricyclic inhibitors of the GPIIb IIIa receptor A tricylic benzodiazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions fo... | 01/06/1998 |
| 5703258 | Silicon and phosphorus containing compositions A flame retardant organic silicon and phosphorus containing compound is produced by reacting a silicon halides compound with an organic phosphorus compound to produce an organic silicon and phosphorus halides compound which is then reacted with an organic... | 12/30/1997 |
| 5703208 | 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease ... | 12/30/1997 |
| 5691436 | Production of silicon-phosphorus containing compositions A mixture of silicon and phosphorus are heated and reacted with halide to produce silicon tetrahalides, silicon-phosphorus halide and phosphorus trihalides compositions. These compositions are reacted with any suitable organic, inorganic-organic and/or in... | 11/25/1997 |
| 5633250 | Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms Disclosed us a compound of Formula 1.0: ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formul... | 05/27/1997 |
| 5587375 | Azepinone compounds useful in the inhibition of ACE and NEP Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R1, R2, R3, R4... | 12/24/1996 |
| 5585488 | Process for producing indolocarbazole derivatives In the formulae, R1, R2, and R3 independently represent lower alkyl or aryl, and R4 represents lower alkyl. The present invention relates to a process for producing an indolocarbazole derivative represented by Formul... | 12/17/1996 |
| 5504080 | Benzo-fused lactams Compounds of the formula ##STR1## wherein A is ##STR2## are useful as ACE and NEP inhibitors and those wherein A is ##STR3## are useful as ACE inhibitors. Methods of preparation and intermediates are also disclosed.... | 04/02/1996 |
| 5496943 | Heterocyclic compounds and their production Disclosed is a novel heterocyclic compound selected from the group consisting of the compounds [IV] to [VII], [IX] and [X]. The heterocyclic compound is useful for reactive materials in chemical industry. A process for producing the heterocyclic compound ... | 03/05/1996 |
