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| Number | Title | Issue Date |
| 7402675 | Process for the synthesis of amine ethers from secondary amino oxides An amine ether of formula A wherein a is 1 or 2; and when a is 1, E is E′; when a is 2, E is L; E′ is C1-C36 alkyl; C3-C18 alkenyl; C2 | 07/22/2008 |
| 7326698 | Prostaglandin analogs Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, and E are as described herein. These compounds are useful for treating diseases. ... | 02/05/2008 |
| 7323563 | Hydroxamic acid derivatives as antibacterials A method for the treatment of bacterial infections in humans and non-human mammals, which comprises inhibiting bacterial growth by administering to a subject an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily accepta... | 01/29/2008 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7270752 | Process for purifying lactams A process is described for purifying lactams, in particular the lactams obtained by cyclizing hydrolysis of an aminoalkylnitrile, and more particularly to the purification by crystallization of ε-caprolactam obtained by cyclizing hydrolysis of aminocapronitrile. Th... | 09/18/2007 |
| 7220869 | Brønsted acidic room temperature ionic liquids each having a -protonated lactam cation and method for preparing the same The invention relates to a class of novel Brønsted acidic ionic liquids each having a lactam cation, and to a method for preparing the same through simple neutralization reaction of a lactam, which is available in large scale from industry, with a Brønsted inorgan... | 05/22/2007 |
| 7135542 | Bidentate ligands for the carbonylation of unsaturated compounds Bidentate ligand of formula (I), R1R2M1-R-M2R3R4 wherein M1 and M2 each indenpendently represent P, As or Sb; R1, R2, R3 and R4 each i... | 11/14/2006 |
| 7132533 | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R2, R3 and R4 are as defined in the specification) pharmaceutical compositions cont... | 11/07/2006 |
| 7109233 | Protease inhibitors This invention relates in general to certain substituted substituted 1,1,4-1l6-trioxo[1,2]thiazepan-4-ylamides of formula I as defined herein which are protease inhibitors. ... | 09/19/2006 |
| 7087596 | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders This invention relates to new 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives of formula (1) having anticonvulsant activity which are useful as therapeutic agents for the treatment or prevention of epilepsy and other neurological disorders. The inven... | 08/08/2006 |
| 7060705 | Mitotic kinesin inhibitors The present invention relates to quinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which compr... | 06/13/2006 |
| 7026473 | Process for the carbonylation of pentenenitrile Processes to prepare 5-cyanovaleric acid or its ester are provided, by carbonylation of a pentenenitrile, wherein pentenenitrile is reacted with carbon monoxide and water and/or an alcohol in the presence of a catalyst system. The catalyst system contains: ... | 04/11/2006 |
| 7022844 | Amide-based compounds, production, recovery, purification and uses thereof Methods are disclosed of producing and purifying at least one amide. In accordance with one of the methods disclosed herein, the at least one amide is produced by providing an organic liquid comprising at least one oxime, providing at least one catalyst, adding the ... | 04/04/2006 |
| 6916807 | Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as ... | 07/12/2005 |
| 6900328 | Process for the synthesis of amine ethers from secondary amino oxides An amine ether of formula (A) wherein a is 1 or 2; and when a is 1, E is E′; when a is 2, E is L; E′ is C1-C36 alkyl; C3-C18 alkenyl; C2-C18 alkinyl; C5-C18 cycloalkyl; C | 05/31/2005 |
| 6900201 | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G... | 05/31/2005 |
| 6896772 | Method for separating ammonia from solutions containing caprolactam and ammonia A process for distillative removal of ammonia from solutions (I) which include a lactam and ammonia comprises effecting said removal in a distillation apparatus (a) at an absolute pressure of less than 10 bar. ... | 05/24/2005 |
| 6841709 | Method of cutting polymer chains and method for producing chemical raw materials The present invention is to provide a technology to establish a new cycle-based organic chemical industry, which may be called a polymer cascade (polymer reflux industry) wherein the polymer substances shall not remain the final products, but still give birth to syn... | 01/11/2005 |
| 6821963 | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical,... | 11/23/2004 |
| 6743912 | Storage and transportation of N-vinyl-epsilon-caprolactam A method of storing and transporting N-vinyl-ε-caprolactam is provided wherein the N-vinyl-ε-caprolactam is kept in the liquid phase. ... | 06/01/2004 |
| 6743911 | Process for the carbonylation of pentenenitrile Processes to prepare 5-cyanovaleric acid or its ester are provided, by carbonylation of a pentenenitrile, wherein pentenenitrile is reacted with carbon monoxide and water and/or an alcohol in the presence of a catalyst system. The catalyst system contains: (a... | 06/01/2004 |
| 6727241 | Anti-inflammatory compositions and methods of use The present invention is directed to pharmaceutical compositions containing active compounds, which inhibit the activity of the chemokines, MIP-1α and RANTES. It also is directed to methods of treating inflammatory and immunoregulatory disorders and diseases using ... | 04/27/2004 |
| 6686350 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 02/03/2004 |
| 6673920 | Method for the production of N-alkenyl-amides A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst diols of the general formula (I) ... | 01/06/2004 |
| 6664248 | 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides Compounds of formula ##STR1## wherein A is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a group ##STR2## R1 is hydrogen... | 12/16/2003 |
| 6632964 | Process for production of aliphatic aldehyde-acid and/or aliphatic dicarboxylic acid and catalyst for the production A process of producing an aliphatic aldehyde-acid (e.g., adipaldehyde-acid) and/or an aliphatic dicarboxylic acid (e.g., adipic acid) comprising oxidizing a cyclic ketone (e.g., cyclohexanone) with molecular oxygen in the presence of a fixed catalyst whic... | 10/14/2003 |
| 6624303 | Method for producing N-alkenyl amides A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst compounds of the general formulae (I... | 09/23/2003 |
| 6608175 | Serine protease inhibitors Certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases, are prepared in various embodiments using Grignard reagents and alkyllithium reagents and various aldehydes to make oxadiazole, thiadiazo... | 08/19/2003 |
| 6605670 | Resorcinolic derivatives and methods of making and using the same Methods of making low molecular weight methylene acceptors are provided. The methylene acceptors are prepared by reacting a polyhydric phenol with an aromatic olefinic compound in the presence of an acid catalyst, and then further reacting the products of... | 08/12/2003 |
| 6583281 | Stabilized N-alkenyllactam The invention provides an N-alkenyllactam having at least a 6-membered lactam ring, stabilized by phenothiazine and/or derivatives thereof, and a process for the stabilization of N-alkenyllactams.... | 06/24/2003 |
| 6555542 | Sulfonamide lactam inhibitors of FXa and method Sulfonamide lactams of the following formula ##STR1## wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8 are as described herein, ... | 04/29/2003 |
| 6548516 | 1-(3-heteroarylpropyl- or -prop-2-enyl)-4-benzylpiperidines used as NMDA receptor antagonists Piperidine derivatives of the formula I ##STR1## and their physiologically acceptable salts in which X, Y, Z, R1, R2, R3 and R4 are as defined in claim 1 can be as excitatory amino acid antagonists for combating neur... | 04/15/2003 |
| 6489315 | Cyclic compounds, their production and use Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C | 12/03/2002 |
| 6479658 | Method for cyclizing hydrolysis of an aminonitrile compound into lactam The invention relates to a process for the cyclizing hydrolysis of an aminonitrile compound into a lactam in the presence of a catalyst. The invention relates more particularly to a process for the cyclizing hydrolysis of an aminonitrile compound in the presen... | 11/12/2002 |
| 6468996 | Substituted hetero-polycyclic compounds as PPAR and PPARγ activators The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 10/22/2002 |
| 6455521 | Condensed thiophene compounds and pharmaceutical use thereof A condensed thiophene compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a nov... | 09/24/2002 |
| 6417356 | Stabilization of vinylether and vinyl lactam formulations against hydrolysis This invention relates to a composition containing (a) a component selected from the group of a mono- or poly- vinyl substituted mono- or poly-ether, a mono- or poly- vinyl substituted lactam, or a mixture thereof contained in an acidic medium and (b) an ... | 07/09/2002 |
| 6387893 | Spirotricyclic substituted azacycloalkane derivatives and uses thereof Spirotricyclic azacycloalkyl compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds is also described. One application of these compounds, which are alpha 1a adrenergic receptor antagonists, is in the treat... | 05/14/2002 |
| 6359128 | Free-flowing flakes of vinyl caprolactam monomer and process for making same Free-flowing flakes of vinyl caprolactam monomer usable below its melting point of 34° C. without developing coloration.... | 03/19/2002 |
| 6344560 | Nitroaromatic solubilizer for nitroxyls in aromatic solvents A nitroaromatic compound is used to enhance the solubility of a nitroxyl compound in an aromatic hydrocarbon solvent.... | 02/05/2002 |
