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| Number | Title | Issue Date |
| 7214714 | 20-hydroxyeicosatetraenoic acid production inhibitors A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R1 represents a substituted morpholino group, a substituted piperidino group, a... | 05/08/2007 |
| 7199158 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,... | 04/03/2007 |
| 6515024 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/04/2003 |
| 6423689 | Peptidyl calcium channel blockers The present invention provides compounds that block calcium channels having the Formula I shown below. ##STR1## The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy an... | 07/23/2002 |
| 6372903 | Method for preparing polyazacycloalkanes grafted on silica gel and use of grafted compounds The invention concerns a method for preparing polyazacycloalkanes immobilised on a silica gel from a polyazacycloalkane of formula (A) in which: R1 and R2 represent a hydrogen atom, an alkyl radical, or a [hetero(aryl)]alkyl radical;... | 04/16/2002 |
| 6362174 | Reduced dipeptide analogues as calcium channel antagonitsts The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma. The nov... | 03/26/2002 |
| 6337398 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: ##STR1## wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 01/08/2002 |
| 6316440 | Reduced dipeptide analogues as calcium channel antagonists ##STR1## The present invention provides novel N-type calcium channel blockers, compositions comprising them, and methods of their use. The compounds of the invention are useful in the treatment of stroke, cerebral ischemia, pain, epilepsy, and head trauma... | 11/13/2001 |
| 6281206 | Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically accepta... | 08/28/2001 |
| 6225302 | Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically accepta... | 05/01/2001 |
| 6100394 | Long-lived homogenous oxidation catalysts A robust chelate complex is provided having the formula: ##STR1## wherein: M is a metal, preferably a transition metal; Z is an anionic donor atom, three of which are nitrogen, and the other is oxygen; L1 is a labile ligand; Ch1... | 08/08/2000 |
| 6093723 | 4-substituted beta-carbolines and analogs thereof This invention relates to 4-substituted ଲ-carbolines and ଲ-carboline analogs that inhibit Ca+2 influx and interleukin-2 (IL-2) production. The 4-substituted ଲ-carbolines and ଲ-carboline analogs of this invention are repr... | 07/25/2000 |
| 6054580 | Long-lived homogenous amide containing macrocyclic compounds A robust compound is provided having the formula: ##STR1## wherein Y1, Y2, Y3 and Y4 are oxidation resistant groups which are the same or different and which form 5- or 6-membered rings with a metal, M, whe... | 04/25/2000 |
| 5859002 | HIV protease inhibitors HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain the... | 01/12/1999 |
| 5852007 | Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/22/1998 |
| 5847120 | Long-lived homogenous oxidation catalysts A robust chelate complex is provided having the formula: ##STR1## wherein M is a metal, preferably a transition metal; Z is an anionic donor atom, at least three of which are nitrogen and the other is preferably nitrogen or oxygen; L1 is a... | 12/08/1998 |
| 5741799 | Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R1, R2, R3, G, Gx, R6', Ra, Xa, R6, Rb, R3, p, Q, A and R4 are as defined... | 04/21/1998 |
| 5691356 | Disubstituted heterocyclic thrombin inhibitors Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q is a single bond or ##STR3## and Z... | 11/25/1997 |
| 5686483 | Aminoalkyloximes Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/11/1997 |
| 5686446 | Aminoalkyloximes Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/11/1997 |
| 5686447 | Aminoalkyloximes for treating depression and affective disorders Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/11/1997 |
| 5684021 | Aminoalkyloximes for treating depression and affective disorders Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/04/1997 |
| 5665756 | Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders Novel aminoalkyloximes of the formula ##STR1## wherein: a. X is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, or a group of the formula ##STR2## wherein Y is hydrogen or loweralkyl, and p is 1 or 2; b. A is a group of the for... | 09/09/1997 |
| 5583146 | Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R1, R2, R3, G, Gx, R6', Ra, Xa, R6, Rb, R3, p, Q, A and R4 are as defined... | 12/10/1996 |
| 5561146 | Modified guanidino and amidino thrombin inhibitors Thrombin inhibitors are provided which have the formula ##STR1## wherein Z is a thrombin inhibitor substructure containing distal and proximal binding site residues; and R1 is cyano, hydroxyl, alkoxy, amino, aminoalkyl or nitro.... | 10/01/1996 |
| 5428157 | 3-acylaminobenzodiazepines 3-Acylamino-5-Aminobenzo[1,5]diazepines are useful in the treatment of arrhythmia. The compounds have structural formulae: ##STR1##... | 06/27/1995 |
| 5367072 | Reagents for automated synthesis of peptide analogs Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.... | 11/22/1994 |
| 5292755 | USPA benzolyguanidines Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O)n -- or R(7)R(8)N--O2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O)... | 03/08/1994 |
| 5274098 | Amidinophenylalanine derivatives, process for their preparation, their use and compositions containing them Amidinophenylalanine derivatives, a process for their preparation, their use and pharmaceutical compositions which contain these compounds are described.... | 12/28/1993 |
| 5120843 | Pharmaceutically active amines The aromatic amines (I), alkyl amines (II), bicyclic amines (III). ##STR1## cycloalkyl amines (IV), aromatic bicyclic amines (V), hydroquinone amines (VI), quinone amines (VII), amino-ethers (VIII) and bicyclic amino ethers (IX) are useful as pharmac... | 06/09/1992 |
| 5089471 | Peptidyl beta-aminoacyl aminodiol carbamates as anti-hypertensive agents Non-peptidyl compounds characterized generally as ଲ-aminoacyl aminodiol carbamates are useful as renin inhibitors for the treatment of hypertension.... | 02/18/1992 |
| 5041545 | 2-hydroxybenzophenone hydrazides and derivatives thereof Hydrazide functionalized 2-hydroxybenzophenone ultraviolet light and heat stabilizers and derivatives are disclosed having the general formula: ##STR1## wherein R1, R2, R3, R4, R5, R6, X, Y... | 08/20/1991 |
| 4977141 | Peptidyl -aminoacyl aminodiol carbamates as anti-hypertensive agents Non-peptidyl compounds characterized generally as aminoacyl aminodiol carbamates are useful as renin inhibitors for the treatment of hypertension.... | 12/11/1990 |
| 4968677 | Substituted 1-aryl-2-napthoylamines and their use as microbicides 1-Aryl-2-naphthoylamines of formula I are described ##STR1## wherein R1 is halogen, nitro, cyano, C1 -C6 alkyl that is unsubstituted or mono- or poly-substituted by halogen and/or C1 -C3 alkoxy, ... | 11/06/1990 |
| 4781866 | Process for producing amidine sulfonic acid intermediates for guanidines An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): ##STR1## with H2 O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can th... | 11/01/1988 |
| 4762821 | N',N"-dialkylguanidino dipeptides N',N"-dialkylguanidino dipeptides with angiotension converting enzyme (ACE) inhibiting activity are useful as antihypertensives. Proline and proline analogs are components of the dipeptides.... | 08/09/1988 |
| 4735959 | Carboxylic acid amides and pharmaceutical compositions containing them There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula I... | 04/05/1988 |
| 4673747 | Aminoalkylphenoxy derivatives Substituted aminoalkylphenoxy derivatives represented by the general formula of: ##STR1## wherein the substituting group Z is either one of the following groups of: ##STR2## were prepared. These derivatives exert antagonism against Histamine ... | 06/16/1987 |
| 4578471 | Substituted amino alkyl pyridyl ethanediimidamides Histamine H2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepar... | 03/25/1986 |
| 4567174 | Bis(1-substituted biguanide) derivatives A bis(1-substituted biguanide) derivative of the formula: or a tautomeric form thereof, wherein R1, R2 and R9, which may be the same or different, are each hydrogen, a 1-16C alkyl radical, a 3-16C cycloalkyl radical, a (3-12C c... | 01/28/1986 |
