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| Number | Title | Issue Date |
| 7420052 | Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines An intermediate for vinblastine synthesis represented by general formula A. general formula A. (in the formula, R1, R2, R3 and R4 are the group selected independently fr... | 09/02/2008 |
| 7285533 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 10/23/2007 |
| 7238704 | Vinca derivatives The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed. ... | 07/03/2007 |
| 7235564 | Vinorelbine derivatives The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed. ... | 06/26/2007 |
| 7060290 | Phosphocholine linked prodrug derivatives Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or unsubstituted alkyl, (ii) substituted or unsubstituted alkenyl, (iii) substitute... | 06/13/2006 |
| 6746668 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 06/08/2004 |
| 6482825 | Growth-hormone secretagogues This invention provides compounds of formula I ##STR1## and pharmaceutically-acceptable salts thereof, where the substituents are defined in the specification, which are growth hormone secretogogues useful for treatment and prevention of osteoporosis, con... | 11/19/2002 |
| 6177444 | Allosteric adenosine receptor modulators The present invention relates to compounds of formulas (IA), (IB), and (IC): ##STR1## the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection ag... | 01/23/2001 |
| 6127377 | Vinca alkaloid antimitotic halogenated derivatives The invention concerns novel halogenated derivatives of the vinblastine and vinorelbine family, corresponding to general formula (I) and their therapeutically acceptable salts. The invention also concerns the application of these compounds in therapy and ... | 10/03/2000 |
| 6127333 | Conjugates useful in the treatment of prostate cancer Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized ... | 10/03/2000 |
| 6011041 | Use of anhydrovinblastine The present invention is particularly directed to the use of a derivative of vinblastine, 3',4'-anhydrovinblastine (AHVB), which differs from vinblastine in that it possesses a double bond at the 3',4' position of the caranthine nucleus rather than the hy... | 01/04/2000 |
| 5948750 | Conjugates useful in the treatment of prostate cancer Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of pro... | 09/07/1999 |
| 5882881 | Inhibition of cyst formation by cytoskeletal specific drugs The invention provides a method of producing a culture of polycystic kidney cells which form cysts in vitro. A cell culture of polycystic kidney cells is also provided. A method for screening an agent in vitro to determine the effectiveness of the agent i... | 03/16/1999 |
| 5789189 | Inhibition of cyst formation by cytoskeletal specific drugs The invention provides a method of producing a culture of polycystic kidney cells which form cysts in vitro. A cell culture of polycystic kidney cells is also provided. A method for screening an agent in vitro to determine the effectiveness of the agent i... | 08/04/1998 |
| 5744607 | Basic derivatives of glutamic acid and aspartic acid as gastrin or cholecystokinin antagonists The invention is directed to glutamic acid and aspartic acid derivatives represented by formula (I): ##STR1## wherein R1 is selected from the group consisting of unsubstituted, mono- or di-substituted phenyl groups, unsubstituted, mono- or... | 04/28/1998 |
| 5667764 | Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance... | 09/16/1997 |
| 5665358 | Antibody drug-conjugates Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of ଲ-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an e... | 09/09/1997 |
| 5620985 | Antimitotic binary alkaloid derivatives from catharanthus roseus Novel fluorinated derivatives of the vinblastine and vinorelbine family of general formula (1), ##STR1## wherein the symbols have the meanings indicated in the Specification and Claims, and the therapeutically-acceptable salts of these molecules, as ... | 04/15/1997 |
| 5432279 | Process for the preparation of binary indole alkaloids The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added... | 07/11/1995 |
| 5391549 | Cinnoline-3-carboxylic acid derivatives A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical formulations containing the same for the preve... | 02/21/1995 |
| 5387578 | New linker for bioactive agents Conjugate of general formula 1: [A--O--W-Z]a -T 1 wherein the moity A--O--is the residue of drug of formula A--O--H in which --O--H is a primary or secondary hydroxyl group; a is an integer of from 1 to 30; W is... | 02/07/1995 |
| 5334385 | New alkaloid derivatives, their use and pharmaceutical formulations containing them Salts of a pharmacologically active, naturally occurring or synthetic alkaloids, or alkaloid derivatives and a phosphatidic acid are provided, which preferably have the formula [Alk]x [PA]y wherein Alk represents a cation derived from sai... | 08/02/1994 |
| 5294611 | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones The invention provides novel 2,3,6 substituted quinazolinones having the formula: ##STR1## wherein R6, R and X are as described in the specification, which have activity as angiotensin II (AII) antagonists.... | 03/15/1994 |
| 5220016 | Synthesis of navelbine analogs The invention is a de novo synthesis of the norcatharanthine moiety of navelbine. The synthesis includes condensing a Grignard reagent prepared from an amine-protected R(+)-piperidinyl methanol with an N-protected 2-methoxyoxalyl indole. The indole N-prot... | 06/15/1993 |
| 5114919 | Adjuncts in cancer chemotherapy Various cyproheptadine derivatives sensitize multidrug resistant cells to certain chemotherapeutic agents. As such, these cyproheptadine derivatives are useful as adjuncts in the reversal of multidrug resistance in mammalian tumor cells either as compound... | 05/19/1992 |
| 5100881 | N-(23-vincristinoyl) and N-(5'-noranhydro-23-vinblastinoyl) compounds of 1-aminomethylphosphonic acid useful for the treatment of neoplastic diseases The invention relates to the compounds of general formula I: ##STR1## in which: R1 represents a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or branched alkenyl radical containing from 2 t... | 03/31/1992 |
| 5095109 | Novel alkaloids Cycloalkyl and aromatic vinblastine and vincristine derivatives useful as anti-tumor agents.... | 03/10/1992 |
| 5055449 | Vincristine-containing product The present invention provides a pharmaceutical product for combating cancer with vincristine as active constituent, the neuropathic complications being prevented by a peptide. The product according to the invention contains: (a) vincristine or a salt the... | 10/08/1991 |
| 5047528 | Process of synthesis of vinblastine and vincristine The present invention relates to the synthesis of dimer alkaloid compounds, particularly those of the Catharantus (Vinca) family, from an indole unit, such as cantharanthine, and a dihydroindole unit, such as vindoline. A multi-step process is disclosed i... | 09/10/1991 |
| 5043340 | Derivatives of 4-desacetyl VLB C-3 carboxhydrazide Derivatives of 4-desacetyl VLB C-3 carboxhydrazide, active anti-tumor agents and useful as intermediates for active anti-tumor conjugates.... | 08/27/1991 |
| 5043336 | Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide Cyclic imide derivatives of 4-desacetyl VLB C-3 carboxydrazide, active anti-tumor agents.... | 08/27/1991 |
| 5037977 | Method for production of dimeric alkaloids This invention concerns a method for the production of dimeric alkaloids, characterized by reacting of catharanthine with vindoline in the presence of Fe3+ and (1) removing or inactivating the Fe3+ and allowing the reaction product... | 08/06/1991 |
| 5030620 | Vinblastine derivatives, and pharmaceutical compositions containing them A description is given of conjugates of vinca alkaloid of the indole-dihydroindole type with a protein or a protein fragment, corresponding to the general formula ##STR1## in which R1 denotes a protein or a protein fragment; R2 ... | 07/09/1991 |
| 5006652 | Intermediates for antibody-vinca drug conjugates A seris of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comp... | 04/09/1991 |
| 4959367 | 4-oxo-1,2,3-benzotriazines Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein X is N or CH; R1 and R2 are the same or different and are hydrogen, halogen, CF3, C1-6 alkyl, C1-7 acyl, C... | 09/25/1990 |
| 4946833 | N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid useful for treating neoplastic diseases The invention relates to N-(23-vinblastinoyl)compounds of 1-aminomethylphosphonic acid of general formula I ##STR1## in which: R1 denotes a hydrogen atom, a linear or branched alkyl radical containing from 1 to 6 carbon atoms, a linear or ... | 08/07/1990 |
| 4935509 | Novel alkaloids Cycloalkyl and aromatic vinblastine and vincristine derivatives useful as anti-tumor agents.... | 06/19/1990 |
| 4897477 | Synthesis of vinblastine and vincristine type compounds A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.... | 01/30/1990 |
| 4895853 | Antitumor alkaloids This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine org... | 01/23/1990 |
| 4895854 | Antitumor alkaloids This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine org... | 01/23/1990 |
