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| Number | Title | Issue Date |
| 7345056 | Bridged N-cyclic sulfonamido inhibitors of gamma secretase The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1... | 03/18/2008 |
| 7314870 | Compounds, their preparation and use The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention ... | 01/01/2008 |
| 7081531 | Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists Compounds having the formula (I), Ar—(F)-(E)-(CR3R4)—(CHR5)m-(T)-(Q)-Ar1, are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridg... | 07/25/2006 |
| 7057035 | N-hydroxysuccinimide process for conversion of phenols to carboxamides A process for converting an aryl triflate, heteroaryl triflate, aryl halide or heteroaryl halide to an N-hydroxysuccinimido ester is disclosed. The process involves reacting the triflate or halide with carbon monoxide and N-hydroxysuccinimide in a solvent in the pre... | 06/06/2006 |
| 6887868 | Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I): wherein: R1, R2, R3, R4, R5, R6 R7, R8, n, m, and X have any of the value... | 05/03/2005 |
| 6849619 | Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, ... | 02/01/2005 |
| 6720316 | Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and Z have any of the values defined ... | 04/13/2004 |
| 6699852 | Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) ##STR1## or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9... | 03/02/2004 |
| 6482567 | Oxime sulfonate and N-oxyimidosulfonate photoacid generators and photoresists comprising same New photoacid generator compounds ("PAGs") are provided and photoresist compositions that comprise such compounds. In particular, non-ionic PAGs are provided that contain an oxime sulfonate group, and/or an N-oxyimidosulfonate group. PAGs of the invention... | 11/19/2002 |
| 6465491 | 6-phenylpyridyl-2-amine derivatives The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central ner... | 10/15/2002 |
| 6410534 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds... | 06/25/2002 |
| 6387512 | Grey coloring photochromic fused pyrans A photochromic grey coloring 2H-naphtho[1,2-b]pyran of formula (1) wherein R1 is selected from mono-, di- or poly-substituted aryl groups, mono-, di- or poly-substituted naphthyl groups and mono-, di- or poly-substituted heteroaryl groups, wher... | 05/14/2002 |
| 6323194 | Muscarinic agonists and antagonists The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.... | 11/27/2001 |
| 6235747 | 6-phenyl-pyridin-2-ylamine derivatives The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central ner... | 05/22/2001 |
| 6211360 | Ibogamine congeners The present invention is directed to compounds having formula (1), wherein n is from 0 to 8; R1 is CH2 OH, CH(OH)R5, CH2 OR5, CO2 R5, C(O)NH2, C(I)NHR5, C(O)NR | 04/03/2001 |
| 6130330 | Process for preparing macropolycyclic polyamines What is claimed is a process for preparing macropolycyclic polyamines of the formula ##STR1## where A1, A2, A3 and A4 are as defined in the description. These compounds are prepared by a novel improved proc... | 10/10/2000 |
| 6048980 | Process of preparing tetraaza tetraacetic acid The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles. ##STR1##... | 04/11/2000 |
| 6040442 | Process for preparing 1,2,5-thiadiazole containing ethers The presently claimed process provides a method for preparing compounds of the formula ##STR1## phosphorous (III) compound and a diester of azodicarboxylate.... | 03/21/2000 |
| 5977129 | Azacyclic and azabicyclic substituted oxa- or thia-diazole compounds The present invention relates to compounds of formula I: wherein one or both G is an azacyclic ring of formula II: ##STR1## and Z is oxygen or sulfur and the remaining variables are as defined in the specification. The compounds are useful as stimulants o... | 11/02/1999 |
| 5952324 | Bicyclic oxazine and thiazine oxazolidinone antibacterials Phenyloxazolidinone compound of formula (I)or a pharmaceutically acceptable salt thereof characterized by a bicyclic thiazine or oxazine substituent. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathoge... | 09/14/1999 |
| 5912343 | Tertiary amines containing side-chain organolithium structures and method for the preparation thereof A compound comprising at least one cyclic amine, having an organolithium side-chain, defined according to formula (I) ##STR1## wherein Z is a lithium atom (Li); R1 is selected from the group consisting of organic groups containing from 1 t... | 06/15/1999 |
| 5854239 | Diazabicyclic neuokinin antagonists The present invention relates to diazabicyclic compounds and, specifically, to compounds of the formula ##STR1## wherein A, G, R1, R2, R3, R4, R5, R6, and R7 are as defined ... | 12/29/1998 |
| 5852189 | Tertiaryaminoalkyllithium initiators and the preparation thereof Relatively pure tertiaryaminoalkyllithium initiators suitable for anionic polymerization reactions are prepared at low temperatures in an organic ether by reacting an equivalent excess of lithium metal with a tertiaryaminoalkylhalide. The lithium initiato... | 12/22/1998 |
| 5849731 | Indole derivatives and medical application thereof The present invention relates to indole derivatives represented by the following compound 1 and the pharmacologically acceptable acid addition salt thereof. ##STR1## The compounds of the present invention were found to exhibit strong antitussive... | 12/15/1998 |
| 5834456 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents Polyazamacrocyclofluoromonoalkylphosphonic acid compounds are disclosed which form inert complexes with Gd, Mn, Fe or La ions. The complexes are useful as contrast agents for diagnostic purposes.... | 11/10/1998 |
| 5834454 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof A substituted guanidine derivative represented by the general formula: ##STR1## wherein R1, R2, R3 and R4 are independently a hydrogen atom, an unsubstituted alkyl group, a substituted alkyl group, a halogen ... | 11/10/1998 |
| 5744607 | Basic derivatives of glutamic acid and aspartic acid as gastrin or cholecystokinin antagonists The invention is directed to glutamic acid and aspartic acid derivatives represented by formula (I): ##STR1## wherein R1 is selected from the group consisting of unsubstituted, mono- or di-substituted phenyl groups, unsubstituted, mono- or... | 04/28/1998 |
| 5741788 | Heterocyclic compounds and their preparation and use The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv... | 04/21/1998 |
| 5733924 | DC 107 derivatives and treatment methods DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, wherein R1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrah... | 03/31/1998 |
| 5728843 | (2'-nitro-1'-imidazolyl)-2,3-isopropylidene-y-tosylbutanol, a precursor to 18 F!fluoroerythronitroimidazole PET imaging agent The present invention involves a rapid synthesis of 18 F-FMISO and analogs thereof. New precursors such as 1-(2'-nitro-1'-imidazolyl)-2-0-acetyl-3-0-tosylpropanol, glycerol-1,3-ditosylate-2-0-acetylate, 1-(2'-nitro-1'-imidazolyl)-2,3-0-dia... | 03/17/1998 |
| 5707985 | Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators There are disclosed novel substituted naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives that are useful in a method of treating immuno-inflammatory diseases in a mammalian patient suffering therefrom. Pharmaceutical compositions containing the... | 01/13/1998 |
| 5679673 | Aralkyl bridged diazabicycloalkane derivatives for CNS disorders Certain aralkyl diazabicycloalkyl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each of R, R1, R4 | 10/21/1997 |
| 5643848 | Soluble anionic polymerization initiators and products therefrom An acyclic alkane soluble anionic polymerization initiator includes a mixture of from about 90 to about 10 parts by weight of a lithio amine having the general formula A1 Li and from about 10 to about 90 parts by weight of at least one other li... | 07/01/1997 |
| 5578542 | Soluble anionic polymerization initiators and method of preparing same An acyclic alkane soluble anionic polymerization initiator includes a mixture of from about 90 to about 10 parts by weight of a lithio amine having the general formula A1 Li and from about 10 to about 90 parts by weight of at least one other li... | 11/26/1996 |
| 5512579 | Aminobenzoic acid derivatives To provide a compound which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio. An aminobenzoic acid derivative represented by the general formula (I) or (II) or a pharmacologically accepta... | 04/30/1996 |
| 5498614 | Bridged aza-bicyclic derivatives as substance P antagonist The invention relates to bridged aza-bicyclic derivatives of formula (I). These compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders. Also disclosed are intermediates used in the synthesis ... | 03/12/1996 |
| 5414009 | Azabicyclo substituted oxa- or thia-diazole compounds The present invention relates to compounds ##STR1## where G is ##STR2## and Z is oxygen or sulfur and the remaining variables are as defined in the Specification. The compounds are useful as stimulants of the cognitive function of the foreb... | 05/09/1995 |
| 5352685 | Thieno[3,2-b]pyridine derivatives The thieno[3.2-b]pyridine derivative of the present invention promote the gastric emptying in male ddy mice and the gastric contraction in dogs sutured with a strain-gauge transducer. It is believed that the derivatives have the action to enhance gastric ... | 10/04/1994 |
| 5329005 | Soluble anionic polymerization initiators and preparation thereof The present invention is directed toward anionic polymerization initiators which are soluble in hydrocarbon solvents. The initiators include a lithio amine having the general formula ALi. The component A is a dialkyl or dicycloalkyl amine radical or a cyc... | 07/12/1994 |
| 5256671 | Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy Compounds of formula (I), and salts and prodrugs thereof: ##STR1## wherein Q is the residue of an optionally substituted azabicyclic ring system; the dotted line represents an optional double bond; X represents H, --OH, .dbd.O or halo; R1 repre... | 10/26/1993 |
